Results 51 to 60 of about 2,169,057 (252)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2017 The article describes experimental investigation of a method of reducing the drag of a circular cylinder. We consider installation of a flat plate parallel to the flow before the cylinder.
V. A. Frolov, A. S. Kozlova
doaj +1 more source
The Effects of Stress on Second Harmonics in Plate-Like Structures
Applied Sciences, 2020 Cumulative second harmonic of ultrasonic guided waves is considered to have great application potential in evaluating internal stress of structures.
Xiaochuan Niu, Liqiang Zhu, Zujun Yu
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
R32 Partial Condensation Inside A Brazed Plate Heat Exchanger [PDF]
, 2012 It is well known that when a superheated gas reaches a cold surface, the condensation starts immediately only if the wall temperature is lower than the dew temperature of the refrigerant; in this case, the heat transfer phenomenon can be also affected by
Mancin, Simone +2 more
core +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Journal of Marine Science and EngineeringPlate structures are the main components of offshore platforms and ships in engineering applications. The vibration control of the low-frequency mode of plate structures has always been a meaningful research object in marine science and engineering.
Yuan Du +5 more
doaj +1 more source
The Interaction between the Plane Wave and the Plate with Limited Height in Soil [PDF]
Учёные записки Казанского университета: Серия Физико-математические науки, 2017 A solution of the two-dimensional task on interaction between the harmonic wave and the plate with the limited height in soil has been provided. The plate surrounded on both sides with the half-spaces filled with soil medium has been used as a vibro ...
N.A. Lokteva +3 more
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