Results 41 to 50 of about 1,085,462 (251)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Comparison of fixation techniques in Vancouver type AG periprosthetic femoral fracture: a biomechanical study

Acta Orthopaedica et Traumatologica Turcica, 2020
Objective: The purpose of this study was to biomechanically compare cable, trochanteric grip plate, and locking plate techniques in Vancouver type AG fracture model in an in vitro test environment.
Kerim Sarıyılmaz, Murat Korkmaz, Okan Özkunt, Halil Can Gemalmaz, Mustafa Sungur, Murat Baydoğan   +5 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Finite element analysis (FEA) of polylactic acid/polypropylene carbonate (PLA/PPC) blends fixation plate for craniomaxillofacial surgery

, 2019
Purpose: The internal fixation plate of bone fractures by using polylactic acid (PLA) has attracted the attention of many researchers, as it is biodegradable and biocompatible to the human body. However, its brittleness has led to implant fracture.
Abdul Hamid, Abdul Malek, Buys, Yose Fachmi, Mohamed Haneef, Intan Najwa Humaira, Abd Hamid, Abdul Malek, Shaffiar, Norhashimah   +4 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Comparison of the biomechanical properties of a ventral cervical intervertebral anchored fusion device with locking plate fixation applied to cadaveric canine cervical spines [PDF]

, 2013
OBJECTIVE: To evaluate fixation properties of a new intervertebral anchored fusion device and compare these with ventral locking plate fixation. STUDY DESIGN: In vitro biomechanical evaluation.
Bürki, Alexander, Howard, J., Schöllhorn, Bernhard, Stahl, Christina, Forterre, Franck   +4 more
core   +1 more source

Clinical efficacy and biomechanical analysis of 3D-printed guide plate–assisted cannulated screw fixation compared with conventional fixation in complex acetabular fractures

Frontiers in Surgery
BackgroundOptimal fixation for pelvic and acetabular fractures remains challenging due to competing demands for stability and minimally invasive surgery.
Chaoqiang Wang, Chaoqiang Wang, Xiaoyu He, Zhongyu Zhang, Xueli Li, Mei Wang, Feng Zeng, Caosheng Lai, Huimei Li, Peng Chen, Zhiping Zhou   +10 more
doaj   +1 more source

Comparison of palmar locking plate and Kwire augmented external fixation for intraarticular and comminuted distal radius fractures

Acta Orthopaedica et Traumatologica Turcica, 2020
Objectives: This study was designed to compare the results of palmar locking plate and K-wire augmented external fixation in the treatment of intra-articular comminuted distal radius fractures.
Arel Gereli, Ufuk Nalbantoglu, Baris Kocaoglu, Metin Turkmen   +3 more
doaj   +1 more source

Comparison between external locking plate fixation and conventional external fixation for extraarticular proximal tibial fractures: a finite element analysis

Journal of Orthopaedic Surgery and Research, 2022
Background Good clinical outcomes for locking plates as an external fixator to treat tibial fractures have been reported. However, external locking plate fixation is still generally rarely performed.
Dejan Blažević, Janoš Kodvanj, Petra Adamović, Dinko Vidović, Zlatko Trobonjača, Srećko Sabalić   +5 more
doaj   +1 more source