Results 51 to 60 of about 1,085,462 (251)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A biomechanical study of headless compression screws versus a locking plate in radial head fracture fixation

, 2019
Hypothesis: Fixation of a 3-part radial head fracture with cannulated compression screws will show equivalent stiffness to a locking plate under axial load. Debate exists regarding the management of Mason type III fractures, with many believing that open
Rebgetz, PR, Taylor, FJ, Underhill, ID, Öchsner, A, Daniele, L   +4 more
core   +1 more source

Clinical comparison of single posterolateral plate with medial-cannulated-screw fixation and double-plate fixation for extra-articular distal humerus fractures

Journal of Orthopaedics and Traumatology
Background Double-plate fixation is the gold standard for extra-articular distal humerus fractures, but it carries a substantial risk of postoperative ulnar neuropathy.
Hyoung-Seok Jung, Min-Su Chu, Jae-Sung Lee   +2 more
doaj   +1 more source

Finite Element Analysis of a New Pedicle Screw-Plate System for Minimally Invasive Transforaminal Lumbar Interbody Fusion.

PLoS ONE, 2015
PurposeMinimally invasive transforaminal lumbar interbody fusion (MI-TLIF) is increasingly popular for the surgical treatment of degenerative lumbar disc diseases. The constructs intended for segmental stability are varied in MI-TLIF.
Jie Li, Jin Shang, Yue Zhou, Changqing Li, Huan Liu   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Spinal Neuronavigation for Lumbar Plate Fixation in Miniature Breed Dogs. [PDF]

OBJECTIVE  The main aim of this pilot study was to assess the feasibility of spinal neuronavigation for plate fixation of lumbar vertebrae in miniature breed dogs using a surgical navigation system in combination with a custom-made reference array.
Guevar, Julien, Schweizer, Daniela, Müller, Andrea, Papacella-Beugger, Angela, Samer, Eva, Progin, Alexia, Planchamp, Bastien, Forterre, Franck   +7 more
core   +1 more source

Single versus Double Plate Fixation in Condylar Neck Fractures: Clinical Results and Biomechanics Simulation

Bioengineering
The open reduction of mandibular condyle neck fractures is difficult due to the limited surgical field and complex facial nerve structures. The most effective fixation method for narrow fractured segments is debated as standard double four-hole plate ...
Chien-Chung Chen, Ting-Han Chiu, Cheng-Yu Yan, Ya-Pei Hou, Ting-Sheng Lin   +4 more
doaj   +1 more source

Comparison of the fixation ability between lag screw and bone plate for oblique metacarpal shaft fracture

Journal of Orthopaedic Surgery and Research, 2022
Background For oblique metacarpal shaft fracture, if anatomical reduction is achieved through conservative cast immobilization rather than stable fixation, bone malrotation can easily occur, resulting in severe loss in hand prehensile function.
Yung-Cheng Chiu, Tsung-Yu Ho, Cheng-En Hsu, Yen-Nien Ting, Ming-Tzu Tsai, Jui-Ting Hsu   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Experimental and Finite Element Studies of Acetabular Cement Pressurisation and Socket Fixation in Total Hip Replacement [PDF]

, 1997
PhDWith time, the rate of symptomatic acetabular component loosening accelerates and overtakes that of the femoral component as the principal reason for the revision of total hip replacement.
New, Andrew Michael Raymond
core   +4 more sources