Results 71 to 80 of about 1,085,462 (251)

Biomechanical comparison of four different internal fixation constructs applied to stabilise Letenneur type I Hoffa fractures: a finite element analysis

BMC Musculoskeletal Disorders
Objective To simulate and compare the biomechanical characteristics of different internal fixation constructs for treating Letenneur type I Hoffa fractures via finite element analysis to establish a theoretical foundation for selecting a fixation method ...
YM Cha, XD Jian, Bo Chang, Peng Sun
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Conical coupling angular stable plate fixation: A retrospective study

, 2020
Backgrounds. Conical coupling represents an alternative to screw coupling on angular stable plate fixation. Aims of the present study was to evaluate clinical effectiveness and ease of plate removal of conical coupling locking plates into different ...
Maiello, Alessio, Maniscalco, Pietro, Di Stefano, Giovanni, Quattrini, Fabrizio, Rivera, Fabrizio   +4 more
core   +1 more source

Breaking the treatment dilemma of Schatzker IV fractures: finite element analysis validates hybrid single-plate with tension screw fixation for synergistic optimization of stability and minimally invasive outcomes

Frontiers in Bioengineering and Biotechnology
ObjectiveThe core challenge in treating Schatzker type IV tibial plateau fractures lies in balancing mechanical stability with minimally invasive techniques. Traditional double-plate fixation carries a high risk of soft tissue complications, while single-
Mingxiang Liu, Zulong Zhou, Chaofan Wu, Chaoqun Wu, Run Fang, Chengnan Zhang, Lingchao Kong, Rende Ning   +7 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Functional outcome of conservative and surgical management in mid-third clavicle fractures

Journal of Orthopedics, Traumatology and Rehabilitation, 2015
Purpose: Clavicle fracture traditionally treated conservatively. There is a growing trend to treat displaced mid-shaft clavicular fractures with primary open reduction and plate fixation; whether such treatment results in improved patient outcomes is ...
Chandra Prakash Pal, Rajendra Kumar Shakunt, Deepak Kumar, Amrit Goyal, Aditya Prakash Tyagi, Trilok Chand Pippal   +5 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Mechanical Comparison of Headless Screw Fixation and Locking Plate Fixation for Talar Neck Fractures

, 2015
For talar neck fractures, open reduction and internal fixation have been thought to facilitate revascularization and prevent osteonecrosis. Newer screw systems allow for placement of cannulated headless screws, which provide compression by virtue of a ...
KARAKAŞLI, AHMET, HAPA, ONUR, Dincer, Cemal, ERDURAN, MEHMET, ÇEÇEN, BERİVAN, HAVITÇIOĞLU, HASAN   +5 more
core   +1 more source

Fixation of distal fibular fractures: A biomechanical study of plate fixation techniques [PDF]

, 2017
Ankle fractures are complex injuries with variable prognoses that depend upon many factors. The aim of the treatment is to restore the ankle joint biomechanical stability with maximum range of motion.
Horny, L., Kachlik, D., Horak, Z., Baca, W., Marvan, J., Vilimek, M.   +5 more
core   +1 more source

Title of the study: finite element analysis of five internal fixation modalities for Schatzker type IV‒C tibial plateau fractures

BMC Musculoskeletal Disorders
Background This study aims to evaluate the biomechanical performance of five different internal fixation strategies for Schatzker type IV-C tibial plateau fractures using three-dimensional finite element analysis.
Zulong Zhou, Run Fang, Yulong Liu, Mingxiang Liu, Lingchao Kong, Rende Ning   +5 more
doaj   +1 more source