Results 91 to 100 of about 6,135,874 (298)
Bending and buckling of three-dimensional graphene foam plates
Results in Physics, 2019 Bending and buckling behaviors of three-dimensional graphene foam (3D-GrF) plates are investigated in the framework of the two-variable refined plate theory (TRPT).
Yan Qing Wang, Zhi Yuan Zhang
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
An Electromechanical Model for Clamped-Edge Bimorph Disk Type Piezoelectric Transformer Utilizing Kirchhoff Thin Plate Theory. [PDF]
Sensors (Basel), 2022 Chen SE, Gunawan H, Wu CC.
europepmc +1 more source
Shock and Vibration, 2013 Dynamic analysis of foundation plate-beam systems with transverse shear deformation is presented using modified Vlasov foundation model. Finite element formulation of the problem is derived by using an 8-node (PBQ8) finite element based on Mindlin plate ...
Korhan Ozgan
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Nonlinear Finite Element Model for Bending Analysis of Functionally-Graded Porous Circular/Annular Micro-Plates under Thermomechanical Loads Using Quasi-3D Reddy Third-Order Plate Theory. [PDF]
Materials (Basel), 2023 Kim J, Nava E, Rakici S.
europepmc +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
New Interpretation of Plate Structure Theory Optimization Design Training Program
, 2019 The world competitive sports games showing a very competitive situation the winner will have to participate in the support behind is a high level of theory and technology more discipline involved in training to improve the effect of training quality ...
Wen Tianyang, Wen Bo
core
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source