Results 81 to 90 of about 6,135,874 (298)

The stability of the press plate by creep theory

open access: yesLietuvos Matematikos Rinkinys, 1999
According to creep theory incurves of pressed plate increasing during the time. It means that defor­mated plate is not stable.
Algimantas Bartaševičius
doaj   +3 more sources

Application of the Method of Initial Functions to Study Dynamics and Stress Distribution in Structural Members

open access: yesAdvances in Civil Engineering
This study investigates plate analyses employing the method of initial functions (MIFs) across various plate geometries and loading conditions. The conclusions derived from thick rectangular plates highlight substantial thickness-induced effects on ...
Jitendra Namdeo   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

ON HAMILTONIAN FORMULATIONS AND CONSERVATION LAWS FOR PLATE THEORIES OF VEKUA-AMOSOV TYPE

open access: yesInternational Journal for Computational Civil and Structural Engineering, 2017
Some variants of the generalized Hamiltonian formulation of the plate theory of I. N. Vekua – A. A. Amosov type are presented. The infinite dimensional formulation with one evolution variable, or an “instantaneous” formalism, as well as the de Donder ...
Sergey I. Zhavoronok
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

BENDING ANALYSIS OF HOMOGENEOUS, ISOTROPIC LINEAR ELASTIC SQUARE PLATES UNDER VARIOUS BOUNDARY CONDITIONS

open access: yesAcademy Journal of Science and Engineering
This research investigates the bending behaviour of homogeneous, isotropic linear-elastic square plates under various boundary conditions, with a focus on evaluating deflection and stress.
John Oluyinka Edunro   +1 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Stability of Cracked Plates with Nonlinearly Variable Thickness Resting on Elastic Foundations

open access: yesJournal of Materials and Engineering Structures, 2022
In this paper, the stability of rectangular cracked plates with nonlinearly variable thickness resting on the elastic foundations is studied. The thickness of the plate varies exponentially along the x-axis.
Vinh An LE, Minh Phuc PHAM, Tuan Anh BUI
doaj  

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