Results 61 to 70 of about 6,135,874 (298)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Comment on ‘Fully covariant radiation force on a polarizable particle’

New Journal of Physics, 2014
Recently Pieplow and Henkel (2013 New J. Phys. http://dx.doi.org/10.1088/1367-2630/15/2/023027 15 http://dx.doi.org/10.1088/1367-2630/15/2/023027 ) presented a new fully covariant theory of the Casimir friction force acting on small neutral particle ...
A I Volokitin, B N J Persson
doaj   +1 more source

A nth-order shear deformation theory for composite laminates in cylindrical bending

Curved and Layered Structures, 2015
The present study investigates whether an nthorder shear deformation theory is applicable for the composite laminates in cylindrical bending. The theory satisfies the traction free conditions at top and bottom surfaces of the plate and does not require ...
Sayyad A. S., Ghugal Y. M.
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Bending of the rigidly fixed elastic-plastic plate

Қарағанды университетінің хабаршысы. Математика сериясы, 2019
The number of plate structures include coatings, as well as box systems, working as a complete spatial system. The plate structures include systems elements of which are both rods and plates, for example, frame - panel structures with the bearing ...
L.S. Assetova, B.M. Nurlanova, I.A. Samoilova   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A Theory for the Mechanism of Chromium Plating; A Theory for the Physical Characteristics of Chromium Plate

Transactions of The Electrochemical Society, 1947
This paper describes a general study of the structural characteristics of chromium plate and of the mechanism of chromium plating. New fundamental data are presented on the crystal structure of chromium deposited from chromic acid solutions. In view of deposition conditions producing the various structural modifications, a hypothesis for the plating ...
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Systematic investigation of different formulations for drug delivery through the human nail plate "in vitro" [PDF]

, 2010
Human nails do not have only protective and decorative role, but can also be considered as an alternative pathway for drug delivery, especially in nail diseases such as onychomycosis or psoriasis.
Vejnoviċ, Ivana
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source