Results 21 to 30 of about 1,198,051 (418)

Platelet-activating factor acetyl hydrolase IB2 dysregulated cell proliferation in ovarian cancer. [PDF]

Cancer Cell Int, 2021
Background Ovarian cancer is the leading cause of death from gynaecologic illnessed worldwide. Platelet-activating factor acetyl hydrolase IB2 (PAF-AH IB2) is an intracellular serine esterase that hydrolyzes platelet-activating factor, a G-protein-like ...
He Y, He Z, Zhang X, Liu S.
europepmc   +2 more sources

Molecular Docking, Drug likeness Studies and ADMET prediction of Flavonoids as Platelet-Activating Factor (PAF) Receptor Binding [PDF]

Chemical Review and Letters, 2021
Studies and scientific research indicate that the platelet-activating factor (PAF) is a major pro-inflammatory mediator in the initiation and development of cancer.
Mohammed BOUACHRINE, Larbi Elmchichi, Abdellah El Aissouq, Assia BELHASSAN, Hanane Zaki, Abdelkrim Ouammou, Tahar Lakhlifi   +6 more
doaj   +1 more source

Anti–platelet factor 4 antibodies causing VITT do not cross-react with SARS-CoV-2 spike protein

Blood, 2021
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a severe adverse effect of ChAdOx1 nCoV-19 COVID-19 vaccine (Vaxzevria) and COVID-19 vaccine Janssen (Ad26.COV2.S), and associated with unusual thrombosis.
A. Greinacher, K. Selleng, J. Mayerle, R. Palankar, J. Wesche, S. Reiche, A. Aebischer, T. Warkentin, M. Muenchhoff, J. Hellmuth, O. Keppler, D. Duerschmied, A. Lother, S. Rieg, M. Gawaz, K. Mueller, C. Scheer, M. Napp, K. Hahnenkamp, G. Lucchese, A. Vogelgesang, A. Floeel, P. Lovreglio, Angela Stufano, R. Marschalek, T. Thiele   +25 more
semanticscholar   +1 more source

Increased platelet activating factor levels in chronic spontaneous urticaria predicts refractoriness to antihistamine treatment: an observational study

Clinical and Translational Allergy, 2019
Background Platelet activating factor (PAF) is an endogenous, active phospholipid released from inflammatory cells, platelets, and endothelial cells, and is involved in the regulation of immune responses. Degradation of PAF by PAF acetylhydrolase (PAF-AH)
Bastsetseg Ulambayar, Eun-Mi Yang, Hyun-Young Cha, Yoo-Seob Shin, Hae-Sim Park, Young-Min Ye   +5 more
doaj   +1 more source

Forty Years Since the Structural Elucidation of Platelet-Activating Factor (PAF): Historical, Current, and Future Research Perspectives

Molecules, 2019
In the late 1960s, Barbaro and Zvaifler described a substance that caused antigen induced histamine release from rabbit platelets producing antibodies in passive cutaneous anaphylaxis.
R. Lordan, A. Tsoupras, I. Zabetakis, C. Demopoulos   +3 more
semanticscholar   +1 more source

Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase

Memorias do Instituto Oswaldo Cruz, 2005
Platelet-activating factor (PAF) is one of the most potent lipid mediators involved in inflammatory events. The acetyl group at the sn-2 position of its glycerol backbone is essential for its biological activity.
Hugo C Castro Faria Neto, Diana M Stafforini, Stephen M Prescott, Guy A Zimmerman   +3 more
doaj   +1 more source

A Review of Platelet-Activating Factor As a Potential Contributor to Morbidity and Mortality Associated with Severe COVID-19

Clinical and Applied Thrombosis/Hemostasis, 2021
The precise mechanisms of pathology in severe COVID-19 remains elusive. Current evidence suggests that inflammatory mediators are responsible for the manifestation of clinical symptoms that precedes a fatal response to infection. This review examines the
Mark Klein MD, Vinh Dao PharmD, BCPS, Fatima Khan MD, MPH   +2 more
doaj   +1 more source

Platelet activating factor receptor antagonists improve the efficacy of experimental chemo- and radiotherapy

Clinics, 2018
Platelet activating factor is a lipid mediator of inflammation, and in recent decades, it has emerged as an important factor in tumor outcomes. Platelet activating factor acts by specific binding to its receptor, which is present in both tumor cells and ...
Ildefonso Alves da Silva Junior, Luciana Nogueira de Sousa Andrade, Sonia Jancar, Roger Chammas   +3 more
doaj   +1 more source

Platelet-activating factor podoplanin: from discovery to drug development

Cancer Metastasis Review, 2017
Tumor cell-induced platelet aggregation facilitates hematogenous metastasis by promoting tumor embolization, preventing immunological assaults and shear stress, and the platelet-releasing growth factors support tumor growth and invasion. Podoplanin, also
Ai Takemoto, K. Miyata, N. Fujita
semanticscholar   +1 more source

Score predictor factor analysis: Reproducing observed covariances by means of factor score predictors [PDF]

Front. Psychol. 10:1895 (2019), 2019
The model implied by factor score predictors does not reproduce the non-diagonal elements of the observed covariance matrix as well as the factor loadings. It is therefore investigated whether it is possible to estimate factor loadings for which the model implied by the factor score predictors optimally reproduces the non-diagonal elements of the ...
arxiv   +1 more source