Results 31 to 40 of about 4,500,208 (289)

To hydrolyze or not to hydrolyze: the dilemma of platelet-activating factor acetylhydrolase

Journal of Lipid Research, 2014
Mounting ambiguity persists around the functional role of the plasma form of platelet-activating factor acetylhydrolase (PAF-AH). Because PAF-AH hydrolyzes PAF and related oxidized phospholipids, it is widely accepted as an anti-inflammatory enzyme.
Gopal Kedihitlu Marathe, Chaitanya Pandit, Chikkamenahalli Lakshminarayana Lakshmikanth, Vyala Hanumanthareddy Chaithra, Shancy Petsel Jacob, Cletus Joseph Michael D'Souza   +5 more
doaj   +1 more source

Platelet-activating factor acetyl hydrolase IB2 dysregulated cell proliferation in ovarian cancer

Cancer Cell International, 2021
Background Ovarian cancer is the leading cause of death from gynaecologic illnessed worldwide. Platelet-activating factor acetyl hydrolase IB2 (PAF-AH IB2) is an intracellular serine esterase that hydrolyzes platelet-activating factor, a G-protein-like ...
YingYing He, Zhicheng He, Xiaoyu Zhang, Shubai Liu   +3 more
doaj   +1 more source

Plasma PAF-acetylhydrolase in patients with coronary artery disease: results of a cross-sectional analysis

Journal of Lipid Research, 2003
Inflammation underlies both onset and perpetuation of atherosclerosis. Plasma lipoproteins transport the platelet-activating factor-acetylhydrolase (PAF-AH) with potentially anti-inflammatory activities.
Stefan Blankenberg, Dominique Stengel, Hans J. Rupprecht, Christoph Bickel, Ju¨rgen Meyer, François Cambien, Laurence Tiret, Ewa Ninio   +7 more
doaj   +1 more source

Effects of oxidized low density lipoprotein, lipid mediators and statins on vascular cell interactions [PDF]

, 1999
The integrin heterodimer CD11b/CD18 (alpha M beta 2, Mac-1, CR3) expressed on monocytes or polymorphonuclear leukocytes (PMN) is a receptor for iC3b, fibrinogen, heparin, and for intercellular adhesion molecule (ICAM)-1 on endothelium, crucially ...
Erl, Wolfgang, Weber, Christian, Kim S. C. Weber, Weber, Kim S.C., Weber, Peter C., Wolfgang Erl, Peter C. Weber, Christian Weber   +7 more
core   +1 more source

Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein [PDF]

, 2006
Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that play a crucial role in cardiovascular and inflammatory diseases.
Wolfgang Siess, Siess, Wolfgang
core   +1 more source

Opposing Effects of Platelet-Activating Factor and Lyso-Platelet-Activating Factor on Neutrophil and Platelet Activation

Molecular Pharmacology, 2009
Platelet-activating factor (PAF) is a potent, bioactive phospholipid that acts on multiple cells and tissues through its G protein-coupled receptor (GPCR). PAF is not stored but is rapidly generated via enzymatic acetylation of the precursor 1-O-hexadecyl-2-hydroxy-sn-glycero-3-phosphocholine (lysoPAF). The bioactivity of PAF is effectively and tightly
Emily J, Welch, Ram P, Naikawadi, Zhenyu, Li, Phoebe, Lin, Satoshi, Ishii, Takao, Shimizu, Chinnaswamy, Tiruppathi, Xiaoping, Du, Papasani V, Subbaiah, Richard D, Ye   +9 more
openaire   +3 more sources

Novel molecular analogues of phosphatidylcholines in a lipid extract from bovine brain: 1-long-chain acyl-2-short-chain acyl-sn-glycero-3-phosphocholines.

Journal of Lipid Research, 1989
A vasodepressor phospholipid fraction named Depressor-IA from a bovine brain lipid extract was analyzed by capillary gas-liquid chromatography-mass spectrometry as tert-butyldimethylsilyl derivatives after hydrolysis with phospholipase C.
A Tokumura, K Takauchi, T Asai, K Kamiyasu, T Ogawa, H Tsukatani   +5 more
doaj   +1 more source

Production of platelet-activating factor by washed rabbit platelets

Journal of Lipid Research, 1985
Production of platelet-activating factor by washed rabbit platelets under stimulation with the ionophore A23187 was investigated utilizing two groups of platelet preparations.
M Oda, K Satouchi, K Yasunaga, K Saito
doaj   +1 more source

B-cell-activating factor (BAFF) and platelet-activating factor (PAF) in pregnancies complicated by maternal obesity and diabetes: a preliminary study

The Journal of Maternal-Fetal & Neonatal Medicine, 2023
Objective In pregnancies complicated by maternal obesity and diabetes, a disruption in inflammatory mediators occurs, resulting in endothelial microvascular dysfunction, oxidative stress, tissue damage, and maternal and feto-neonatal complications.
Caterina Neri, Alessandra Ciliberti, Davide Archelao Dessì, Chiara Airoldi, Katia Basello, Andrea Costanzi, Alessandra Familiari, Chiara Tersigni, Mattia Cappelletti, Attilio Francesco Speciani, Antonio Lanzone   +10 more
doaj   +1 more source

Production of platelet-activating factor in slugs.

Journal of Lipid Research, 1991
The land slug, Incilaria bilineata, was shown to contain a large amount of 1-O-alkyl-2-acyl (long chain)-sn-glycero-3-phosphocholine, which accounts for as much as 47% of the choline glycerophospholipid fraction. Since this unique either phospholipid has
T Sugiura, T Ojima, T Fukuda, K Satouchi, K Saito, K Waku   +5 more
doaj   +1 more source