Results 21 to 30 of about 4,500,208 (289)

The Roles of Platelet-Activating Factor and Magnesium in Pathophysiology of Hypertension, Atherogenesis, Cardiovascular Disease, Stroke and Aging

Cardiogenetics, 2022
Hypertension and atherosclerosis are debilitating diseases that affect millions each year. Long-term consequences include but are not limited to stroke, myocardial infarction, and kidney failure.
Nilank Shah, Roshni Sethi, Sachin Shah, Komail Jafri, Jonah Duran, Yong Chang, Chirag Soni, Hanna Wollocko   +7 more
doaj   +1 more source

Molecular Docking, Drug likeness Studies and ADMET prediction of Flavonoids as Platelet-Activating Factor (PAF) Receptor Binding [PDF]

Chemical Review and Letters, 2021
Studies and scientific research indicate that the platelet-activating factor (PAF) is a major pro-inflammatory mediator in the initiation and development of cancer.
Mohammed BOUACHRINE, Larbi Elmchichi, Abdellah El Aissouq, Assia BELHASSAN, Hanane Zaki, Abdelkrim Ouammou, Tahar Lakhlifi   +6 more
doaj   +1 more source

Increased platelet activating factor levels in chronic spontaneous urticaria predicts refractoriness to antihistamine treatment: an observational study

Clinical and Translational Allergy, 2019
Background Platelet activating factor (PAF) is an endogenous, active phospholipid released from inflammatory cells, platelets, and endothelial cells, and is involved in the regulation of immune responses. Degradation of PAF by PAF acetylhydrolase (PAF-AH)
Bastsetseg Ulambayar, Eun-Mi Yang, Hyun-Young Cha, Yoo-Seob Shin, Hae-Sim Park, Young-Min Ye   +5 more
doaj   +1 more source

Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase

Memorias do Instituto Oswaldo Cruz, 2005
Platelet-activating factor (PAF) is one of the most potent lipid mediators involved in inflammatory events. The acetyl group at the sn-2 position of its glycerol backbone is essential for its biological activity.
Hugo C Castro Faria Neto, Diana M Stafforini, Stephen M Prescott, Guy A Zimmerman   +3 more
doaj   +1 more source

Platelet-activating factor receptor plays a role in lung injury and death caused by influenza A in mice [PDF]

, 2010
Influenza A virus causes annual epidemics which affect millions of people worldwide. A recent Influenza pandemic brought new awareness over the health impact of the disease.
Sousa, Lirlandia P., Garcia, Cristina C., Remo C Russo, Salgado, Ana Paula C., Geovanni D. Cassali, Mauro M. Teixeira, Tavares, L.P., Polidoro, Rafael B., Caio T Fagundes, Luciana P Tavares, Tavares, Luciana P., Machado, A.V., Salgado, Ana Paula Carneiro, Rodrigo Guabiraba, Garcia, C.C., Russo, R.C., Cristiana C Garcia, Guabiraba Brito, R., Remo C. Russo, Alexandre V Machado, Machado, Alexandre Vieira, Polidoro, Rafael Barbosa, Caio T. Fagundes, Cassali, Geovanni D., Teixeira, Mauro Martins, Cassali, Geovanni Dantas, Mauro M Teixeira, Lirlândia P. Sousa, Fagundes, C.T., Salgado, A.P.C., Ana Paula C. Salgado, Cassali, G.D., Garcia, Cristiana Couto, Russo, Remo de Castro, Russo, Remo C., Rafael B. Polidoro, Sousa, L.P., Teixeira, M.M., Ana Paula C Salgado, Alexandre V. Machado, Rafael B Polidoro, Machado, Alexandre V., Fagundes, Caio T., Guabiraba, Rodrigo, Cristiana C. Garcia, Polidoro, R.B., Lirlândia P Sousa, Sousa, Lirlândia Pires de, Geovanni D Cassali, Luciana P. Tavares, Teixeira, Mauro M., Salgado, Ana Paula C, Tavares, Luciana P, Machado, Alexandre V, Polidoro, Rafael B, Cassali, Geovanni D, Teixeira, Mauro M, Sousa, Lirlândia P, Garcia, Cristiana C, Russo, Remo C, Fagundes, Caio T   +60 more
core   +2 more sources

Platelet activating factor receptor antagonists improve the efficacy of experimental chemo- and radiotherapy

Clinics, 2018
Platelet activating factor is a lipid mediator of inflammation, and in recent decades, it has emerged as an important factor in tumor outcomes. Platelet activating factor acts by specific binding to its receptor, which is present in both tumor cells and ...
Ildefonso Alves da Silva Junior, Luciana Nogueira de Sousa Andrade, Sonia Jancar, Roger Chammas   +3 more
doaj   +1 more source

Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation [PDF]

, 2005
Oxidation of low-density lipoprotein (LDL) generates proinflammatory and prothrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases.
Siedler, F., Sellmayer, Alois, Gopfert, M. S., Siess, W.   +3 more
core   +1 more source

A Review of Platelet-Activating Factor As a Potential Contributor to Morbidity and Mortality Associated with Severe COVID-19

Clinical and Applied Thrombosis/Hemostasis, 2021
The precise mechanisms of pathology in severe COVID-19 remains elusive. Current evidence suggests that inflammatory mediators are responsible for the manifestation of clinical symptoms that precedes a fatal response to infection. This review examines the
Mark Klein MD, Vinh Dao PharmD, BCPS, Fatima Khan MD, MPH   +2 more
doaj   +1 more source

Anaphylactic shock depends on endothelial Gq/G11 [PDF]

, 2009
Anaphylactic shock is a severe allergic reaction involving multiple organs including the bronchial and cardiovascular system. Most anaphylactic mediators, like platelet-activating factor (PAF), histamine, and others, act through G protein – coupled ...
Nina Wettschureck, Fleming, Ingrid, Schutz, G., Stefan Offermanns, Fleming, I., Angela Wirth, Habermehl, D., Günther Schütz, Offermanns, S., Fißlthaler, Beate, Wirth, A., Moers, Alexandra, Wettschureck, N., Moers, A., Korhonen, H., Habermehl, Daniel, Ingrid Fleming, Fisslthaler, B., Daniel Habermehl, Offermanns, Stefan, Thomas Wieland, Wieland, Thomas, Beate Fisslthaler, Wieland, T., Alexandra Moers, Korhonen, Hanna, Schütz, Günther, Wettschureck, Nina, Hanna Korhonen, Wirth, Angela   +29 more
core   +1 more source

Platelet adhesion in atherogenesis [PDF]

, 2010
A thesis submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Master of PhilosophyPlatelets are known to play a key role in acute coronary events, such as myocardial infarction, associated with advanced
Watkins, Jennifer
core   +3 more sources