Results 31 to 40 of about 1,198,051 (418)

Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture

Reproductive Biology and Endocrinology, 2004
Background Platelet-activating factor and nitric oxide may be involved in the initiation of human labour as inflammatory mediators. The aim of this study was to test whether platelet-activating factor and lipopolysaccharide were able to induce nitric ...
Seyffarth Gunter, Nelson Paul N, Dunmore Simon J, Rodrigo Nalinda, Murphy Damian J, Carson Ray J   +5 more
doaj   +1 more source

Opposing Effects of Platelet-Activating Factor and Lyso-Platelet-Activating Factor on Neutrophil and Platelet Activation

Molecular Pharmacology, 2009
Platelet-activating factor (PAF) is a potent, bioactive phospholipid that acts on multiple cells and tissues through its G protein-coupled receptor (GPCR). PAF is not stored but is rapidly generated via enzymatic acetylation of the precursor 1-O-hexadecyl-2-hydroxy-sn-glycero-3-phosphocholine (lysoPAF). The bioactivity of PAF is effectively and tightly
Zhenyu Li, Chinnaswamy Tiruppathi, Emily J. Welch, Takao Shimizu, Papasani V. Subbaiah, Phoebe Lin, Xiaoping Du, Ram P. Naikawadi, Richard D. Ye, Satoshi Ishii   +9 more
openaire   +4 more sources

The trade-off between factor score determinacy and the preservation of inter-factor correlations [PDF]

arXiv, 2023
Regression factor score predictors have the maximum factor score determinacy, i.e., the maximum correlation with the corresponding factor, but they do not have the same inter-correlations as the factors. As it might be useful to compute factor score predictors that have the same inter-correlations as the factors, correlation-preserving factor score ...
arxiv  

Effects of oxidized low density lipoprotein, lipid mediators and statins on vascular cell interactions [PDF]

, 1999
The integrin heterodimer CD11b/CD18 (alpha M beta 2, Mac-1, CR3) expressed on monocytes or polymorphonuclear leukocytes (PMN) is a receptor for iC3b, fibrinogen, heparin, and for intercellular adhesion molecule (ICAM)-1 on endothelium, crucially ...
Amatruda TT, Bednar MM, Bellosta S, Buttrum SM, Buyon JP, Calara F, Calderon TM, Diacovo TG, Giroux LM, Jukema JW, Kim JA, Kimura M, Laufs U, Laws KH, Lehr H-A, Marcus AJ, Notabartolo A, Olstrowsky L, Pons F, Ruf A, Smalley DM, Stragliotto E, Sugiyama S, Weber C, Weber C, Weber C, Yeagle PL, Yeo EL, Yue TL   +28 more
core   +1 more source

Pharmacologic modulation of experimental postischemic hepatic function [PDF]

, 1989
The present study, evaluated and compared the effects of SRI 63-441, a potent platelet activating factor antagonist, superoxide dismutase (SOD), an oxygen free radical scavenger, and ibuprofen, a cyclooxygenase inhibitor on hepatic function after 90 ...
Makowka, L, Mazzaferro, V, Ontell, SJ, Ove, P, Starzl, TE, Trager, J   +5 more
core   +2 more sources

Hemodialysis membrane-related neutrophil dysfunctions and pentoxifylline - a pilot study [PDF]

, 1990
Hemodialysis treatment is associated with activation of neutrophil granulocytes. Pentoxifylline has been shown to inhibit neutrophil activation in vitro and in vivo.
Hoffmann, H., Jochum, Marianne, Schiffl, H., Spannagl, Michael   +3 more
core   +1 more source

Interplay Between EGFR and the Platelet-Activating Factor/PAF Receptor Signaling Axis Mediates Aggressive Behavior of Cervical Cancer

Frontiers in Oncology, 2020
Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase widely expressed in cervical tumors, being correlated with adverse clinical outcomes. EGFR may be activated by a diversity of mechanisms, including transactivation by G-protein coupled
Juliana L. Souza, Karina Martins-Cardoso, Isabella S. Guimarães, Andréia C. de Melo, Angela H. Lopes, Robson Q. Monteiro, Vitor H. Almeida   +6 more
doaj   +1 more source

Clearance of apoptotic cells by macrophages induces regulatory phenotype and involves stimulation of cd36 and platelet-activating factor receptor [PDF]

, 2013
Phagocytosis of apoptotic cells (efferocytosis) induces macrophage differentiation towards a regulatory phenotype (IL-10high/IL-12p40low). CD36 is involved in the recognition of apoptotic cells (AC), and we have shown that the platelet-activating factor ...
Ferracini, M., Jancar, S., Pecenin, M., Rios, F.J.O.   +3 more
core   +2 more sources

Design, Synthesis and Anti-Platelet Aggregation Activity Study of Ginkgolide-1,2,3-triazole Derivatives

Molecules, 2019
Ginkgolides are the major active component of Ginkgo biloba for inhibition of platelet activating factor receptor. An azide-alkyne Huisgen cycloaddition reaction was used to introduce a triazole nucleus into the target ginkgolide molecules.
Jian Cui, Le’An Hu, Wei Shi, Guozhen Cui, Xumu Zhang, Qing-Wen Zhang   +5 more
doaj   +1 more source

Platelet-Activating Factor Induces Th17 Cell Differentiation

Mediators of Inflammation, 2011
Th17 cells have been implicated in a number of inflammatory and autoimmune diseases. The phospholipid mediator platelet-activating factor (PAF) is found in increased concentrations in inflammatory lesions and has been shown to induce IL-6 production.
Anne-Marie Drolet, Maryse Thivierge, Sylvie Turcotte, Dominique Hanna, Bruno Maynard, Jana Stankovà, Marek Rola-Pleszczynski   +6 more
doaj   +1 more source