Results 61 to 70 of about 1,076,997 (372)

The PON1 M55L gene polymorphism is associated with reduced HDL-associated PAF-AH activity

open access: yesJournal of Lipid Research, 2003
The platelet-activating factor acetylhydrolase activity associated with high density lipoprotein (HDL-PAF-AH) may substantially contribute to the antioxidant, anti-inflammatory, and overall antiatherogenic effects of HDL.
Anna I. Kakafika   +8 more
doaj   +1 more source

Effects of Platelet-Activating Factor on Brain Microvascular Endothelial Cells. [PDF]

open access: yes, 2018
Platelet-activating factor (PAF) is a potent phospholipid mediator that exerts various pathophysiological effects by interacting with a G protein-coupled receptor.
Abood, Mary E.   +4 more
core   +1 more source

Gene Expression Omnibus database analysis reveals comorbidity mechanisms of type 2 diabetes mellitus and vascular dementia and predicts potential herbal therapeutics

open access: yesAdvanced Chinese Medicine, EarlyView.
Abstract Objective This study aimed to investigate the comorbid mechanisms linking type 2 diabetes mellitus (T2DM) and vascular dementia (VaD), focusing on the roles of astrocytes and neurons, and to identify potential therapeutic traditional Chinese medicines (TCMs) and compounds.
Meiyue Li   +5 more
wiley   +1 more source

Prolonged Exposure to Platelet Activating Factor Transforms Breast Epithelial Cells

open access: yesFrontiers in Genetics, 2021
Lipid species are known to have various biological functions owing to their structural differences, and each of them possesses a specific role to play depending upon their location and distribution in the cell. Some of these lipids interact with proteins
Vaishali Chakravarty   +5 more
doaj   +1 more source

Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilis may shift the procoagulant\ue2\u80\u93anticoagulant equilibrium toward thrombosis [PDF]

open access: yes, 2017
Blood coagulation is a finely regulated physiological process culminating with the factor Xa (FXa)-mediated conversion of the prothrombin (ProT) zymogen to active -thrombin (T).
Acquasaliente, Laura   +5 more
core   +1 more source

Multiomics integration of 16S rRNA, metagenomic, and metabolomic analyses unveils gut microbiota–metabolite interactions in Guizhi Fuling capsule‐treated chronic pelvic inflammatory disease rats

open access: yesAdvanced Chinese Medicine, EarlyView.
Guizhi Fuling capsule likely alleviates chronic pelvic inflammatory disease by exerting anti‐inflammatory effects, restoring TCA cycle energy metabolism, reshaping gut microbiota structure, inhibiting quorum sensing signaling, and improving polysaccharide metabolic functions.
Hongli Chen   +8 more
wiley   +1 more source

Platelet-Activating Factor and Pain

open access: yesBiological and Pharmaceutical Bulletin, 2011
Platelet-activating factor (PAF) is a phospholipid mediator that regulates the functions of a variety of cells in the peripheral tissues and in the nervous system. Findings that injection of PAF exogenously at the skin or in the spinal cord induced pain hypersensitivity gave us much attention to its role in pain signaling. Studies using pharmacological
Makoto, Tsuda   +2 more
openaire   +3 more sources

Physicochemical and functional identity of rabbit platelet-activating factor (PAF) released in vivo during IgE anaphylaxis with PAF released in vitro from IgE sensitized basophils.

open access: yesJournal of Immunology, 1979
Platelet activating factor (PAF) released in vivo into the plasmas of rabbits during development of IgE-induced systemic anaphylactic shock had indistinguishable physicochemical and functional properties when compared with PAF released in vitro from ...
R. Neal Pinckard   +2 more
semanticscholar   +1 more source

Impact of Stress‐Induced Hyperglycemia on In‐Hospital Medical Complications in Patients With Acute Stroke: From a Large‐Scale Nationwide Longitudinal Registry

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aims This study aimed to explore the relationship between stress‐induced hyperglycemia (SIH) and in‐hospital medical complications in patients with acute stroke. Methods We enrolled 865,765 patients with acute stroke from the Chinese Stroke Center Alliance cohort.
Xintong Song   +6 more
wiley   +1 more source

Compound Kushen Injection Induces Immediate Hypersensitivity Reaction Through Promoting the Production of Platelet-Activating Factor via de Novo Pathway

open access: yesFrontiers in Pharmacology, 2021
Compound Kushen Injection (CKI) is a bis-herbal formulation extracted from Kushen (Radix Sophorae Flavescentis) and Baituling (Rhizoma Heterosmilacis Yunnanensis). Clinically, it is used as the adjuvant treatment of cancer.
Yuan Gao   +9 more
doaj   +1 more source

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