Inhibition by cardiolipins of platelet‐activating factor‐induced rabbit platelet activation
Lipids, 1993 AbstractEvidence is presented that cardiolipin, a naturally occurring phospholipid, inhibits the aggregatory effect of platelet‐activating factor (paf) on rabbit plateletsin vitro. Bovine heart cardiolipin was shown to inhibit the aggregation of washed rabbit platelets induced by 1×10−10 M and 2×10−10 M paf with IC50 values (doses for half‐maximal ...
Tsoukatos, D. +6 more
openaire +4 more sources
Granulocyte-activating mediators (GRAM) [PDF]
, 1987 In the present study we investigated the capability of human epidermal cells to generate granulocyte-activating mediators (GRAM). It could be shown that human epidermal cells as well as an epidermoid carcinoma cell line (A431) produce an epidermal cell ...
Kapp, A. +8 more
core +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
The factor VII activating protease G511E (Marburg) variant and cardiovascular risk [PDF]
, 2004 A previous study had shown a strong relationship between a variant in factor VII activating protease (FSAP G511E) and advanced carotid atheroma. In-vitro, the variant has reduced fibrinolytic but normal pro-coagulant activity, which may constitute a ...
Ireland, H. +4 more
core
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
REMOVAL OF PLATELET-ACTIVATING-FACTOR IN EXPERIMENTAL CONTINUOUS ARTERIOVENOUS HEMOFILTRATION
, 1995 Objective: There is a positive correlation between the amount of ultrafiltration and the improved survival rate of patients with ischemia or sepsis-induced acute renal failure.
LUPI A +10 more
core +1 more source
Eosinophil Migration in Atopic Dermatitis I: Increased Migratory Responses to N-Formyl-Methionyl-Leucyl-Phenylalanine, Neutrophil-Activating Factor, Platelet-Activating Factor, and Platelet Factor 4 [PDF]
, 1993 Eosinophil granular protein deposits have been demonstrated in lesional atopic dermatitis skin. This suggests active tissue infiltration of eosinophils.
Rihs, Silvia +11 more
core +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
The role of platelet-derived growth factor in radiation injury to the lower urinary tract [PDF]
, 2011 MD ResApproximately half of all patients diagnosed with cancer will receive radiotherapy as a part of the management of their tumours. Radiotherapy allows organ sparing treatment but it is associated with a number of acute and late unwanted effects ...
Sheaff, Michael
core +4 more sources
Journal of Lipid Research, 2005 Oxidation of LDL is thought to be involved in both initiating and sustaining atherogenesis through the formation of proinflammatory lipids and the covalent modification of LDL particles.
Nicolaos Androulakis +3 more
doaj +1 more source