Results 1 to 10 of about 24,555 (234)

Macrophage Derived Platelet Activating Factor Implicated in the Resolution Phase of Gouty Inflammation [PDF]

International Journal of Inflammation, 2014
Human blood derived in vitro differentiated monocytes or macrophages are a population of cells which have been investigated over the years to determine the role these cells play in the resolution phase of gout.
Darshna Yagnik
doaj   +3 more sources

Molecular Docking, Drug likeness Studies and ADMET prediction of Flavonoids as Platelet-Activating Factor (PAF) Receptor Binding [PDF]

Chemical Review and Letters, 2021
Studies and scientific research indicate that the platelet-activating factor (PAF) is a major pro-inflammatory mediator in the initiation and development of cancer.
Mohammed BOUACHRINE, Larbi Elmchichi, Abdellah El Aissouq, Assia BELHASSAN, Hanane Zaki, Abdelkrim Ouammou, Tahar Lakhlifi   +6 more
doaj   +2 more sources

Modulation of inflammatory platelet-activating factor (PAF) receptor by the acyl analogue of PAF [PDF]

Journal of Lipid Research, 2018
Platelet-activating factor (PAF) is a potent inflammatory mediator that exerts its actions via the single PAF receptor (PAF-R). Cells that biosynthesize alkyl-PAF also make abundant amounts of the less potent PAF analogue acyl-PAF, which competes for PAF-
Vyala Hanumanthareddy Chaithra, Shancy Petsel Jacob, Chikkamenahalli Lakshminarayana Lakshmikanth, Mosale Seetharam Sumanth, Kandahalli Venkataranganayaka Abhilasha, Chu-Huang Chen, Anita Thyagarajan, Ravi P. Sahu, Jeffery Bryant Travers, Thomas M. McIntyre, Kempaiah Kemparaju, Gopal Kedihithlu Marathe   +11 more
doaj   +2 more sources

Interaction of Platelet Activating Factor Acetyl Hydrolase (PAF AH) Enzyme in G1n281->Arg281 Mutation Toward PAF and Its Molecular Dynamic

Journal of Tropical Life Science, 2014
Platelet Activating Factor Acetyl Hydrolase (PAF AH) or LpPLA2 is a key enzyme in myocardial infarction catalyzes the sn-2 acetyl group of Platelet Activating Factor (PAF) into lyso PAF and acetate as non-potent inflammatory molecules ...
Jayarani Fatimah Putri , Widodo, M. Saifur Rohman   +2 more
doaj   +1 more source

Platelet-Activating Factor, PAF Acetylhydrolase, and Severe Anaphylaxis [PDF]

New England Journal of Medicine, 2008
Platelet-activating factor (PAF) is an important mediator of anaphylaxis in animals, and interventions that block PAF prevent fatal anaphylaxis. The roles of PAF and PAF acetylhydrolase, the enzyme that inactivates PAF, in anaphylaxis in humans have not been reported.We measured serum PAF levels and PAF acetylhydrolase activity in 41 patients with ...
Vadas, Peter, Gold, Milton, Perelman, Boris, Liss, Gary M, Lack, Gideon, Blyth, Thomas, Simons, F Estelle R, Simons, Keith J, Cass, Dan, Yeung, Jupiter   +9 more
openaire   +4 more sources

Platelet-activating factor induces ferroptosis by binding to ATF3 and inhibiting the SLC7A11/GPX4 axis to suppress the progression of endometrial carcinoma [PDF]

Biology Direct
Background Endometrial carcinoma (EC) is an aggressive gynecological malignancy with high recurrence rates and limited treatment options. Patients with EC exhibit elevated serum levels of lyso-platelet-activating factor (lyso-PAF), a biologically ...
Feifei Pan, Yuqing Qiu, Zhuojie Huang, Yanqin Zheng, Yun Chen, Yiming Song, Zhe-Sheng Chen, Lirong Guo, Jingyao Wang, Xiaojie Liu, Zixin Tao, Yaqiong Liu, Xingcui Xuan, Kunxiang Gong, Kun Shi   +14 more
doaj   +2 more sources

Platelet-activating factor (PAF) promotes immunosuppressive neutrophil differentiation within tumors. [PDF]

Proc Natl Acad Sci U S A
Dahal A, Hong Y, Mathew JS, Geber A, Eckl S, Renner S, Sailer CJ, Ryan AT, Mir S, Lim K, Linehan DC, Gerber SA, Kim M.   +12 more
europepmc   +3 more sources

Thermal Burn Injury Generates Bioactive Microvesicles: Evidence for a Novel Transport Mechanism for the Lipid Mediator Platelet-Activating Factor (PAF) That Involves Subcellular Particles and the PAF Receptor. [PDF]

J Immunol, 2020
Liu L, Fahy KE, Awoyemi AA, Thapa P, Kelly LE, Chen J, Bihl JC, Cool DR, Chen Y, Rapp CM, Johnson RM, Travers JB.   +11 more
europepmc   +3 more sources

Recent topics on platelet-activating-factor(PAF).

Journal of Nippon Medical School, 1988
T, Hasegawa, S, Nakajima
openaire   +4 more sources

Impact of targeting the platelet-activating factor and its receptor in cancer treatment [PDF]

Military Medical Research
The lipid mediator platelet-activating factor (PAF) and its receptor (PAFR) signaling play critical roles in a wide range of physiological and pathophysiological conditions, including cancer growth and metastasis.
Kimya Qaderi, Arvin Shahmoradi, Anita Thyagarajan, Ravi P. Sahu   +3 more
doaj   +2 more sources