Results 31 to 40 of about 4,406,154 (211)

Altered distribution of platelet-activating factor-acetylhydrolase activity between LDL and HDL as a function of the severity of hypercholesterolemia

Journal of Lipid Research, 2002
Platelet-activating factor-acetylhydrolase (PAF-AH) is a lipoprotein-associated phospholipase A2 capable of hydrolyzing platelet-activating factor (PAF) and oxidatively modified phospholipids.
Vasilis Tsimihodimos, Sonia-Athena P. Karabina, Afroditi P. Tambaki, Eleni Bairaktari, George Miltiadous, John A. Goudevenos, Marios A. Cariolou, M. John Chapman, Alexandros D. Tselepis, Moses Elisaf   +9 more
doaj   +1 more source

Characterization of Canine Platelet Activation Induced by Platelet Activating Factor (PAF)

Journal of Veterinary Medical Science, 2008
Characteristics of the signal transduction in Platelet activating factor (PAF)-activated platelets and effects of anti-platelet agents on this response were investigated in vitro for potential therapeutic applications in canine endotoxemia. Blockade of the PAF receptor by a specific blocker has the strongest inhibitive effect on the PAF-induced ...
TSUCHIYA, Ryo, TATSUKI, Yumiko, KITAO, Satoshi, FURUICHI, Mitsuru, NEO, Sakurako, HISASUE, Masaharu, YAMADA, Takatsugu, KOBAYASHI, Kosaku   +7 more
openaire   +3 more sources

Effects of oxidized low density lipoprotein, lipid mediators and statins on vascular cell interactions [PDF]

, 1999
The integrin heterodimer CD11b/CD18 (alpha M beta 2, Mac-1, CR3) expressed on monocytes or polymorphonuclear leukocytes (PMN) is a receptor for iC3b, fibrinogen, heparin, and for intercellular adhesion molecule (ICAM)-1 on endothelium, crucially ...
Erl, Wolfgang, Weber, Christian, Kim S. C. Weber, Weber, Kim S.C., Weber, Peter C., Wolfgang Erl, Peter C. Weber, Christian Weber   +7 more
core   +1 more source

Platelet-Activating Factor Promotes the Development of Non-Alcoholic Fatty Liver Disease

Diabetes, Metabolic Syndrome and Obesity, 2022
Hang Yin, Anhua Shi, Junzi Wu Key Laboratory of Microcosmic Syndrome Differentiation, Yunnan University of Chinese Medicine, Kunming, People’s Republic of ChinaCorrespondence: Junzi Wu; Anhua Shi, Key Laboratory of Microcosmic Syndrome Differentiation ...
Yin H, Shi A, Wu J
doaj  

Effect of safflower yellow on platelet activating factor mediated platelet activation in patients with coronary heart disease

Bangladesh Journal of Pharmacology, 2012
The platelet aggregation and 5-HT release by washed platelet from coronary heart disease patients following platelet activating factor (PAF) treatment were detected by turbidimetry and O-phthalaldehyde assay.
Damin Huang, Yingmin Lu, Xiaohan Luo, Laixin Shi, Jinchun Zhang, Junxian Shen, Minmin Bao, Lei Song, Caiwen Wei, Hongsong Li, Zhihua Li   +10 more
doaj   +1 more source

Platelet-activating factor acetylhydrolase and transacetylase activities in human aorta and mammary artery*

Journal of Lipid Research, 2008
Platelet-activating factor (PAF), the potent phospholipid mediator of inflammation, is involved in atherosclerosis. Platelet-activating factor-acetylhydrolase (PAF-AH), the enzyme that inactivates PAF bioactivity, possesses both acetylhydrolase and ...
Demokritos C. Tsoukatos, Isabelle Brochériou, Vassilios Moussis, Christina P. Panopoulou, Elena D. Christofidou, Stamatis Koussissis, Socratis Sismanidis, Ewa Ninio, Stavros Siminelakis   +8 more
doaj   +1 more source

Reversible cross-tolerance to platelet-activating factor signaling by bacterial toxins

Platelets, 2021
Bacterial toxins signaling through Toll-like receptors (TLRs) are implicated in the pathogenesis of many inflammatory diseases. Among the toxins, lipopolysaccharide (LPS) exerts its action via TLR-4 while lipoteichoic acid (LTA) and bacterial ...
Kandahalli Venkataranganayaka Abhilasha, Mosale Seetharam Sumanth, Anita Thyagarajan, Ravi Prakash Sahu, Kempaiah Kemparaju, Gopal Kedihithlu Marathe   +5 more
doaj   +1 more source

Effect of platelet-activating factor (PAF) on human platelets [PDF]

Blood, 1982
The effect of pure synthetic PAF (1–0-alkyl-2-acetyl-sn-glycero-3- phosphorylcholine) was studied in human platelets. PAF (0.2--2.0 micrograms/ml) produced a dose-dependent aggregation in human platelet- rich plasma (PRP) or platelet suspension obtained by gel-filtration (GFP). In addition, PAF (0.8 microgram/ml) induced secretion of 14C- serotonin (45%
C M, Chesney, D D, Pifer, L W, Byers, E E, Muirhead   +3 more
openaire   +3 more sources

Apafant, a Potent Platelet-Activating Factor Antagonist, Blocks Eosinophil Activation and Is Effective in the Chronic Phase of Experimental Allergic Conjunctivitis in Guinea Pigs

Journal of Pharmacological Sciences, 2004
Platelet-activating factor (PAF) plays important roles in allergic reactions. In particular, there are many concerns about PAF, eosinophils, and the chronicity of allergic diseases.
Masatomo Kato, Kenji Imoto, Hideki Miyake, Tomoko Oda, Suguru Miyaji, Masatsugu Nakamura   +5 more
doaj   +1 more source

Platelet-activating factor (PAF) enhances guinea pig detrusor smooth muscle contractile activities by stimulating voltage-dependent Ca2+ channels and store-operated Ca2+ channels

Journal of Pharmacological Sciences, 2023
We investigated the extracellular Ca2+ influx pathways involved in platelet-activating factor (PAF)-enhanced guinea pig detrusor smooth muscle (DSM) contractile activities.
Keisuke Obara, Mizuki Kaneko, Mio Yamashita, Ge Liu, Kento Yoshioka, Yoshio Tanaka   +5 more
doaj   +1 more source