Results 101 to 110 of about 74,663 (286)

Gout and NLRP3 Inflammasome Biology

Arthritis &Rheumatology, Volume 77, Issue 10, Page 1317-1326, October 2025.
This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilization, and self‐resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal–induced inflammation is reviewed in detail.
Raewyn Poulsen, Nicola Dalbeth
wiley   +1 more source

Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase

Memorias do Instituto Oswaldo Cruz, 2005
Platelet-activating factor (PAF) is one of the most potent lipid mediators involved in inflammatory events. The acetyl group at the sn-2 position of its glycerol backbone is essential for its biological activity.
Hugo C Castro Faria Neto, Diana M Stafforini, Stephen M Prescott, Guy A Zimmerman   +3 more
doaj   +1 more source

Fetal-to-maternal signaling to initiate parturition [PDF]

, 2015
Multiple processes are capable of activating the onset of parturition; however, the specific contributions of the mother and the fetus to this process are not fully understood.
Erin L. Reinl, Gao, Sarah K. England, Shynlova, Shynlova, Silver, Zhu   +6 more
core   +2 more sources

Platelet-activating Factor (PAF)-dependent Transacetylase and Its Relationship with PAF Acetylhydrolases

Journal of Biological Chemistry, 2000
Platelet-activating factor (PAF)-dependent transacetylase (TA) is an enzyme that transfers an acetyl group from PAF to acceptor lipids such as lysophospholipids and sphingosine. This enzyme is distributed in membrane and cytosol of the cells. We previously revealed that TA purified from rat kidney membrane showed an amino acid sequence similarity to ...
K, Bae, L, Longobardi, K, Karasawa, B, Malone, T, Inoue, J, Aoki, H, Arai, K, Inoue, T, Lee   +8 more
openaire   +2 more sources

Anaphylactic Shock Induced by Povidone‐Iodine Vaginal Irrigation During Pregnancy Complicated by Fetal Distress: A Case Report and Literature Review

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Anaphylaxis during pregnancy is common, but severe anaphylaxis during pregnancy is relatively rare and may have serious implications for both the mother and the fetus, potentially leading to maternal death or neonatal death. Anaphylaxis caused by iodophor skin disinfection is commonly observed, but there has been no reported case of severe ...
Yanmei Li, Shilin Zhong
wiley   +1 more source

Platelet Activating Factor Receptor Activation Improves siRNA Uptake and RNAi Responses in Well-differentiated Airway Epithelia

Molecular Therapy: Nucleic Acids, 2014
Well-differentiated human airway epithelia present formidable barriers to efficient siRNA delivery. We previously reported that treatment of airway epithelia with specific small molecules improves oligonucleotide uptake and facilitates RNAi responses ...
Sateesh Krishnamurthy, Mark A Behlke, Michael A Apicella, Paul B McCray, Jr, Beverly L Davidson   +4 more
doaj   +1 more source

Class A CpG Oligonucleotide Priming Rescues Mice from Septic Shock via Activation of Platelet-Activating Factor Acetylhydrolase

Frontiers in Immunology, 2017
Sepsis is a life-threatening, overwhelming immune response to infection with high morbidity and mortality. Inflammatory response and blood clotting are caused by sepsis, which induces serious organ damage and death from shock.
Yoshinari Yamamoto, Yoshinari Yamamoto, Ryu Sugimura, Takafumi Watanabe, Suguru Shigemori, Suguru Shigemori, Takuma Okajima, Shireen Nigar, Shireen Nigar, Fu Namai, Takashi Sato, Tasuku Ogita, Takeshi Shimosato, Takeshi Shimosato   +13 more
doaj   +1 more source

First-Row Transition Metal Complexes Incorporating the 2-(2'-pyridyl)quinoxaline Ligand (pqx), as Potent Inflammatory Mediators: Cytotoxic Properties and Biological Activities against the Platelet-Activating Factor (PAF) and Thrombin. [PDF]

Molecules, 2023
Margariti A, Papakonstantinou VD, Stamatakis GM, Demopoulos CA, Machalia C, Emmanouilidou E, Schnakenburg G, Nika MC, Thomaidis NS, Philippopoulos AI.   +9 more
europepmc   +1 more source

Elevation of plasma phospholipid transfer protein increases the risk of atherosclerosis despite lower apolipoprotein B-containing lipoproteins. [PDF]

, 2004
Plasma phospholipid transfer protein (PLTP) transfers phospholipids between lipoproteins and mediates HDL conversion. PLTP-overexpressing mice have increased atherosclerosis.
Arai, Arie van Tol, Barter, Barter, Bruce, De Geest, Delsing, Ehnholm, Farah Sadeghi-Niaraki, Fielding, Forte, Föger, Herrera, Huuskonen, Jauhiainen, Jessica Lie, Jiang, Jiang, Jiang, Kawano, Leo Scheek, Libby, Lie, Lie, Mackness, Marotti, Mason, Okamoto, Plump, Qin, Quarck, Redgrave, Rien van Haperen, Rini de Crom, Rodrigo, Rye, Shih, Speijer, Tall, Teus van Gent, Tselepis, Tu, Tward, Van Haperen, Van Tol, Van Tol, Watson, Wolfbauer   +47 more
core   +3 more sources

Synthetic studies on platelet-activating factor (PAF).

Chemical and Pharmaceutical Bulletin, 1985
Chemical synthesis of platelet-activating factor (PAF, 1) and its enantiomer was studied. Several alkoxymethyl alkenyl ketones (5a-c, n=14 or 16) were synthesized from Wittig-Horner reagents (4, n=14 or 16) with cyclohexanecarboxaldehyde, octylaldehyde, and benzaldehyde, and subjected to asymmetric reduction with BINAL-H1) which is known to show high ...
H, Suemune, A, Akashi, K, Sakai
openaire   +3 more sources