Results 81 to 90 of about 4,406,154 (211)

Platelet-activating Factor (PAF)-dependent Transacetylase and Its Relationship with PAF Acetylhydrolases

Journal of Biological Chemistry, 2000
Platelet-activating factor (PAF)-dependent transacetylase (TA) is an enzyme that transfers an acetyl group from PAF to acceptor lipids such as lysophospholipids and sphingosine. This enzyme is distributed in membrane and cytosol of the cells. We previously revealed that TA purified from rat kidney membrane showed an amino acid sequence similarity to ...
K, Bae, L, Longobardi, K, Karasawa, B, Malone, T, Inoue, J, Aoki, H, Arai, K, Inoue, T, Lee   +8 more
openaire   +2 more sources

Platelet Activating Factor Antagonist Activity of Ginsenosides.

, 1998
Ginseng saponins and their degradation products have been screened for antagonist activity towards [3H]PAF (platelet activating factor) in washed rabbit platelet receptor binding studies.
Im Seon LEE, Shin Il KIM, Hyeong-Kyu LEE, Keun Young JUNG, Jong Dae PARK, Sei Ryang OH, Dong Seon KIM, Jung Joon LEE, Hyeong Kyu Lee   +8 more
core   +1 more source

Metabolic Dysfunction‐Associated Steatotic Disease and Genetic Risk in Germany—An Observational Real‐World Cohort Study

United European Gastroenterology Journal, Volume 14, Issue 8, October 2026.
ABSTRACT Background Metabolic dysfunction‐associated steatotic disease (MASLD) affects increasing numbers of patients worldwide. The PNPLA3 p.I148M variant represents a major genetic determinant of MASLD progression. The loss‐of‐function HSD17B13 polymorphism rs72613567 was reported in turn to be hepatoprotective.
Marcin Krawczyk, Frank Grünhage, Lisa Schubert, Nektarios Dikopoulos, Jeannette Schwenzer, Marion Muche, Johannes Wiegand, Gisela Felten, Renate Heyne, Patrick Ingiliz, Anna Schmidt, Kerstin Stein, Susanne N. Weber, Heiner Wedemeyer, Stefan Zeuzem, Peter Buggisch, Frank Lammert, Andreas Geier, Wolf Peter Hofmann, Jörn M. Schattenberg   +19 more
wiley   +1 more source

Platelet Activating Factor Receptor Activation Improves siRNA Uptake and RNAi Responses in Well-differentiated Airway Epithelia

Molecular Therapy: Nucleic Acids, 2014
Well-differentiated human airway epithelia present formidable barriers to efficient siRNA delivery. We previously reported that treatment of airway epithelia with specific small molecules improves oligonucleotide uptake and facilitates RNAi responses ...
Sateesh Krishnamurthy, Mark A Behlke, Michael A Apicella, Paul B McCray, Jr, Beverly L Davidson   +4 more
doaj   +1 more source

Failed Mucosal Allostasis Distinguishes Murine IgG‐ From IgE‐Mediated Recurrent Severe Anaphylaxis

Allergy, Volume 81, Issue 10, Page 3673-3694, October 2026.
This study investigates IgE‐ and IgG‐mediated pathways in acute and recurrent anaphylaxis using a murine ASA‐PSA model, assessing barrier integrity, immune activation and tissue remodelling across pulmonary and intestinal compartments. Recurrent IgE‐ and IgG‐mediated anaphylaxis produces divergent mucosal outcomes despite comparable systemic severity ...
Abdurrahman Simsek, Muhammed Ali Kizmaz, Tugce Bozkurt, Sude Toprakkaz, Mehmet Emre Topcu, Musa Ozgur Ozyigit, Ahmet Akkoc, Dane Ediger, Ferah Budak Sener   +8 more
wiley   +1 more source

First-Row Transition Metal Complexes Incorporating the 2-(2'-pyridyl)quinoxaline Ligand (pqx), as Potent Inflammatory Mediators: Cytotoxic Properties and Biological Activities against the Platelet-Activating Factor (PAF) and Thrombin. [PDF]

Molecules, 2023
Margariti A, Papakonstantinou VD, Stamatakis GM, Demopoulos CA, Machalia C, Emmanouilidou E, Schnakenburg G, Nika MC, Thomaidis NS, Philippopoulos AI.   +9 more
europepmc   +1 more source

Revisiting Platelet‐Activating Factor in Asthma: An Exploratory Metabolomics Analysis of PAF C‐18:1 and Type 2 Inflammation

Allergy, EarlyView.
Noeul Kang, Young Jin Pyung, Deog Kyeom Kim, Cheol‐Heui Yun, Hyun Woo Lee   +4 more
wiley   +1 more source

Identification of Platelet-Activating Factor Acetylhydrolase II in Human Skin [PDF]

, 2002
Platelet-activating factor acetylhydrolases are a family of specialized phospholipase A2 enzymes. They serve an anti-inflammatory function by converting the proinflammatory autocoid, PAF, into biologically inactive lyso-PAF, by the removal of the sn-2 ...
Johnston, John M., Marques, Mariangela, Inoue, Takao, Seltmann, Holger, Arai, Hiroyuki, Zouboulis, Christos C., Travers, Jeffrey B., Pei, Yong, Southall, Michael D., Aoki, Junken   +9 more
core   +1 more source

Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase

Memorias do Instituto Oswaldo Cruz, 2005
Platelet-activating factor (PAF) is one of the most potent lipid mediators involved in inflammatory events. The acetyl group at the sn-2 position of its glycerol backbone is essential for its biological activity.
Hugo C Castro Faria Neto, Diana M Stafforini, Stephen M Prescott, Guy A Zimmerman   +3 more
doaj   +1 more source

Platelet-activating factor (PAF) strongly enhances contractile mechanical activities in guinea pig and mouse urinary bladder. [PDF]

Sci Rep, 2022
Liu G, Kaneko M, Yoshioka K, Obara K, Tanaka Y.   +4 more
europepmc   +1 more source