Results 61 to 70 of about 4,406,154 (211)

RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses

, 2001
To define the role of regulators of G-protein signaling (RGS) in chemoattractant-mediated responses, RGS4 and the receptors for platelet-activating factor (PAFR), formylated peptides (FR), or interleukin-8 (CXCR1) were stably coexpressed in a rat ...
Barr, A.J., Richardson, R.M., Snyderman, R., Marjoram, R.J.   +3 more
core   +1 more source

Clinical significance of plasma PAF acetylhydrolase activity measurements as a biomarker of anaphylaxis: Cross-sectional study.

PLoS ONE, 2021
IntroductionPlatelet-activating factor (PAF) has a direct role as a mediator in the pathogenesis of various disorders with an inflammatory component, including those with allergic aetiology.
Krzysztof Łukasz Piwowarek, Agnieszka Rzeszotarska, Jolanta Łukasz Korsak, Aleksandra Juszkiewicz, Andrzej Chciałowski, Jerzy Kruszewski   +5 more
doaj   +1 more source

The emerging roles of PAF acetylhydrolase

Journal of Lipid Research, 2009
Platelet-activating factor (PAF), a phospholipid autacoid with potent effects throughout the innate immune system, is selectively degraded by two small families of PAF acetylhydrolases (PAF-AHs).
Thomas M. McIntyre, Stephen M. Prescott, Diana M. Stafforini   +2 more
doaj   +1 more source

Hypotensive actions of some analogues of platelet-activating factor (PAF) with higher potencies than natural PAF

, 1984
Substituents on the nitrogen atom of the phosphorylcholine moiety of natural C16 platelet-activating factor (PAF) were modified or replaced by more bulky groups, and their hypotensive activities were examined with rats.
Yukinori Masuda, Koki Shigenobu, Yutaka Kasuya   +2 more
core   +1 more source

Aspirin induces non-enzymatic formation of platelet-activating factor from lyso platelet-activating factor [PDF]

, 1993
Substantial amounts of platelet-activating factor (PAF) were formed when lysoPAF was mixed with aspirin (e.g. 0.04% of added lysoPAF (200 nmol) was converted to PAF when mixed with aspirin (2 μmol) for 1 h).
Cheng, Neng-neng, Waku, Keizo, Neng-neng Cheng, Sugiura, Takayuki, Takayuki Sugiura, Kiyoko Mabuchi-Itoh, Mabuchi-Itoh, Kiyoko, Keizo Waku   +7 more
core   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Differential regulation of formyl peptide and platelet-activating factor receptors: role of phospholipase Cbeta3 phosphorylation by protein kinase A

, 1998
Formylated peptides (e.g. n-formyl-Met-Leu-Phe (fMLP)) and platelet-activating factor (PAF) mediate chemotactic and cytotoxic responses in leukocytes through receptors coupled to G proteins that activate phospholipase C (PLC).
Ricardo M. Richardson, Ali, H., Barr, A.J., Bodduluri Haribabu, Silvano Sozzani, Ralph Snyderman, Haribabu, B., Fisher, I., Richardson, R.M., Ian Fisher, Sozzani, S., Snyderman, R., Hydar Ali, Alastair J. Barr   +13 more
core   +1 more source

Is platelet activating factor (PAF) an important mediator in bronchial asthma?

Mediators of Inflammation, 1992
The development of selective PAF receptor antagonists may provide a novel approach to the treatment of human bronchial asthma. In preclinical animal models of human asthma, PAF receptor antagonists have been found to be efficacious in blocking antigen ...
R. H. Gundel, H. O. Heuer, L. G. Letts
doaj   +1 more source

A possible role for platelet-activating factor in the hydrogen peroxide-induced TXB2 and PGE2 glomerular synthesis.

Journal of Lipid Research, 1995
Hydrogen peroxide stimulates both prostanoid and platelet-activating factor (PAF) biosynthesis in cultured rat mesangial cells and isolated rat glomeruli.
I Arribas-Gómez, I Duque-Marín, G Pérez de Lema, M L Díez-Marqués, J Lucio-Cazaña, M Rodríguez-Puyol, D Rodríguez-Puyol   +6 more
doaj   +1 more source

Platelet‐activating factor‐receptor signaling mediates solar‐simulated light‐induced extracellular vesicle release in human keratinocytes

Photochemistry and Photobiology, EarlyView.
Solar‐simulated light (SSL) promotes extracellular vesicle (EV) release from keratinocytes through a UVB‐driven, oxidative stress‐dependent pathway. SSL‐induced reactive oxygen species (ROS) generate oxidized glycerophosphocholines with PAF agonistic activity, which activate the Platelet‐activating factor receptor (PAFR), leading to acid ...
Divyanshu Aggarwal, Anita Thyagarajan, Michael G. Kemp, Ravi P. Sahu   +3 more
wiley   +1 more source