Results 21 to 30 of about 74,663 (286)

Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms [PDF]

, 2018
Platelet-activating factor (PAF) stimulates numerous cell types via activation of the G protein-coupled PAF receptor (PAFR). PAFR activation not only induces acute proinflammatory responses, but it also induces delayed systemic immunosuppressive effects ...
FitzGerald, Garret A., Kaplan, Mark H., Ocana, Jesus A., Pawelzik, Sven-Christian, Romer, Eric, Sahu, Ravi, Travers, Jeffrey B.   +6 more
core   +1 more source

Platelet activating factor levels and metabolism in tangier disease: a case study

Lipids in Health and Disease, 2012
Background Tangier disease (TD) is a phenotypic expression of rare familial syndrome with mutations in the ABCA1 transporter. The risk of coronary artery disease in patients with TD is variable.
Kolovou Vana, Papakonstantinou Vasiliki D, Stamatakis George, Verouti Sophia N, Xanthopoulou Marianna N, Kolovou Genovefa, Demopoulos Constantinos A   +6 more
doaj   +1 more source

The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. [PDF]

, 2012
BackgroundLipoprotein-associated phospholipase A2 (Lp-PLA2)/platelet-activating factor acetylhydrolase (PAF-AH) has been implicated in the pathogenesis of cardiovascular disease.
Fehrenbach, Melane L, Haczku, Angela, Jiang, Zhilong, Kokalari, Blerina, Macphee, Colin, Ravaioli, Giulia, Redai, Imre G, Sheardown, Steven A, Wilson, Stephen   +8 more
core   +2 more sources

Pharmacologic modulation of experimental postischemic hepatic function [PDF]

, 1989
The present study, evaluated and compared the effects of SRI 63-441, a potent platelet activating factor antagonist, superoxide dismutase (SOD), an oxygen free radical scavenger, and ibuprofen, a cyclooxygenase inhibitor on hepatic function after 90 ...
Makowka, L, Mazzaferro, V, Ontell, SJ, Ove, P, Starzl, TE, Trager, J   +5 more
core   +2 more sources

Platelet-activating factor acetyl hydrolase IB2 dysregulated cell proliferation in ovarian cancer

Cancer Cell International, 2021
Background Ovarian cancer is the leading cause of death from gynaecologic illnessed worldwide. Platelet-activating factor acetyl hydrolase IB2 (PAF-AH IB2) is an intracellular serine esterase that hydrolyzes platelet-activating factor, a G-protein-like ...
YingYing He, Zhicheng He, Xiaoyu Zhang, Shubai Liu   +3 more
doaj   +1 more source

CAR-T therapy alters synthesis of platelet-activating factor in multiple myeloma patients

Journal of Hematology & Oncology, 2021
The chimera antigen receptor (CAR) T cell therapy is a novel and potential targeted therapy and has achieved satisfactory efficacy in patients with relapsed or refractory multiple myeloma (MM) in recent years. However, cytokine release syndrome (CRS) and
Mengying Ke, Liqing Kang, Ling Wang, Shu Yang, Yajun Wang, Haiyan Liu, Chunyan Gu, Hongming Huang, Ye Yang   +8 more
doaj   +1 more source

Altered distribution of plasma PAF-AH between HDLs and other lipoproteins in hyperlipidemia and diabetes mellitus

Journal of Lipid Research, 2003
Platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase A2 associated with lipoproteins that hydrolyzes platelet-activating factor (PAF) and oxidized phospholipids. We have developed an ELISA for PAF-AH that is more sensitive than previous
Takeshi Kujiraoka, Tadao Iwasaki, Mitsuaki Ishihara, Mayumi Ito, Makoto Nagano, Akito Kawaguchi, Sadao Takahashi, Jun Ishi, Masahiro Tsuji, Tohru Egashira, Irina P. Stepanova, Norman E. Miller, Hiroaki Hattori   +12 more
doaj   +1 more source

Mesenchymal Stromal Cells Modulate PAF-stimulated Equine Alveolar Macrophages [PDF]

Brazilian Archives of Biology and Technology, 2019
Platelet-activating factor (PAF) is a potent proinflammatory mediator that is produced in increased amounts in the lungs of asthmatic humans and horses.
Pedro Vicente Michelotto, Fernanda Zettel Bastos, Fernanda Cristina Mendes Barussi, Alexandra Cristina Senegaglia, Anita Nishiyama   +4 more
doaj   +1 more source

Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor [PDF]

, 2014
Oxidative stress suppresses host immunity by generating oxidized lipid agonists of the platelet-activating factor receptor (PAF-R). Because many classical chemotherapeutic drugs induce reactive oxygen species (ROS), we investigated whether these drugs ...
Al-Hassani, Mohammed, Althouse, Sandra K., Ferracini, Matheus, Harrison, Kathleen A., Konger, Raymond L., Loesch, Mathew, Murphy, Robert C., Ocana, Jesus A., Perkins, Susan M., Sahu, Ravi P., Speicher, Paul J., Sun, Louis, Touloukian, Christopher E., Travers, Jeffrey B., Tyler, Douglas S.   +14 more
core   +1 more source

Physicochemical and functional identity of rabbit platelet-activating factor (PAF) released in vivo during IgE anaphylaxis with PAF released in vitro from IgE sensitized basophils.

Journal of Immunology, 1979
Platelet activating factor (PAF) released in vivo into the plasmas of rabbits during development of IgE-induced systemic anaphylactic shock had indistinguishable physicochemical and functional properties when compared with PAF released in vitro from ...
R. Neal Pinckard, Richard S. Farr, Donald J. Hanahan   +2 more
semanticscholar   +1 more source