Results 21 to 30 of about 24,574 (253)

CAR-T therapy alters synthesis of platelet-activating factor in multiple myeloma patients

Journal of Hematology & Oncology, 2021
The chimera antigen receptor (CAR) T cell therapy is a novel and potential targeted therapy and has achieved satisfactory efficacy in patients with relapsed or refractory multiple myeloma (MM) in recent years. However, cytokine release syndrome (CRS) and
Mengying Ke, Liqing Kang, Ling Wang, Shu Yang, Yajun Wang, Haiyan Liu, Chunyan Gu, Hongming Huang, Ye Yang   +8 more
doaj   +1 more source

Pharmacologic modulation of experimental postischemic hepatic function [PDF]

, 1989
The present study, evaluated and compared the effects of SRI 63-441, a potent platelet activating factor antagonist, superoxide dismutase (SOD), an oxygen free radical scavenger, and ibuprofen, a cyclooxygenase inhibitor on hepatic function after 90 ...
Makowka, L, Mazzaferro, V, Ontell, SJ, Ove, P, Starzl, TE, Trager, J   +5 more
core   +2 more sources

Altered distribution of plasma PAF-AH between HDLs and other lipoproteins in hyperlipidemia and diabetes mellitus

Journal of Lipid Research, 2003
Platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase A2 associated with lipoproteins that hydrolyzes platelet-activating factor (PAF) and oxidized phospholipids. We have developed an ELISA for PAF-AH that is more sensitive than previous
Takeshi Kujiraoka, Tadao Iwasaki, Mitsuaki Ishihara, Mayumi Ito, Makoto Nagano, Akito Kawaguchi, Sadao Takahashi, Jun Ishi, Masahiro Tsuji, Tohru Egashira, Irina P. Stepanova, Norman E. Miller, Hiroaki Hattori   +12 more
doaj   +1 more source

Mesenchymal Stromal Cells Modulate PAF-stimulated Equine Alveolar Macrophages [PDF]

Brazilian Archives of Biology and Technology, 2019
Platelet-activating factor (PAF) is a potent proinflammatory mediator that is produced in increased amounts in the lungs of asthmatic humans and horses.
Pedro Vicente Michelotto, Fernanda Zettel Bastos, Fernanda Cristina Mendes Barussi, Alexandra Cristina Senegaglia, Anita Nishiyama   +4 more
doaj   +1 more source

Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor [PDF]

, 2014
Oxidative stress suppresses host immunity by generating oxidized lipid agonists of the platelet-activating factor receptor (PAF-R). Because many classical chemotherapeutic drugs induce reactive oxygen species (ROS), we investigated whether these drugs ...
Al-Hassani, Mohammed, Althouse, Sandra K., Ferracini, Matheus, Harrison, Kathleen A., Konger, Raymond L., Loesch, Mathew, Murphy, Robert C., Ocana, Jesus A., Perkins, Susan M., Sahu, Ravi P., Speicher, Paul J., Sun, Louis, Touloukian, Christopher E., Travers, Jeffrey B., Tyler, Douglas S.   +14 more
core   +1 more source

Elevated plasma phospholipase A2 and platelet-activating factor acetylhydrolase activity in colorectal cancer

Mediators of Inflammation, 2004
This clinical study reports that blood levels of the pro-inflammatory mediator platelet-activating factor (PAF) did not change in colorectal cancer patients.
Yves Denizot, Véronique Truffinet, Stéphane Bouvier, Alain Gainant, Pierre Cubertafond, Muriel Mathonnet   +5 more
doaj   +1 more source

Altered distribution of platelet-activating factor-acetylhydrolase activity between LDL and HDL as a function of the severity of hypercholesterolemia

Journal of Lipid Research, 2002
Platelet-activating factor-acetylhydrolase (PAF-AH) is a lipoprotein-associated phospholipase A2 capable of hydrolyzing platelet-activating factor (PAF) and oxidatively modified phospholipids.
Vasilis Tsimihodimos, Sonia-Athena P. Karabina, Afroditi P. Tambaki, Eleni Bairaktari, George Miltiadous, John A. Goudevenos, Marios A. Cariolou, M. John Chapman, Alexandros D. Tselepis, Moses Elisaf   +9 more
doaj   +1 more source

Hemodialysis membrane-related neutrophil dysfunctions and pentoxifylline - a pilot study [PDF]

, 1990
Hemodialysis treatment is associated with activation of neutrophil granulocytes. Pentoxifylline has been shown to inhibit neutrophil activation in vitro and in vivo.
Hoffmann, H., Jochum, Marianne, Schiffl, H., Spannagl, Michael   +3 more
core   +1 more source

Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation [PDF]

, 2005
Oxidation of low-density lipoprotein (LDL) generates proinflammatory and prothrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases.
Berliner JA, Bittman R, Casals-Stenzal J, Esterbauer H, Fernandez-Ortiz A, Frey B, Goetzl EJ, Holvoet P, Itabe H, Kamido H, Kamido H, Kern H, Kinsella BT, Kitagawa S, O'Flaherty JT, O'Flaherty JT, Rasmussen UB, Sevanian A, Subbanagounder G, Tanaka T, Trip MD, Volf I, Watson AD, Weidtmann A   +23 more
core   +1 more source

Differential fMet-Leu-Phe- and Platelet-activating Factor-induced Signaling Toward Ral Activation in Primary Human Neutrophils [PDF]

, 1999
We have measured the activation of the small GTPase Ral in human neutrophils after stimulation with fMet- Leu-Phe (fMLP), platelet activating factor (PAF), and granulocyte macrophage-colony stimulating factor and compared it with the activation of ...
Bos, J.L., Coffer, P.J., Koenderman, L., M'Rabet, Laura, Wolthuis, R.M.F., Zwartkruis, G.J.T.   +5 more
core   +5 more sources