Results 61 to 70 of about 158,362 (293)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Inhibitory Effects of Phylligenin and Quebrachitol Isolated from Mitrephora vulpina on Platelet Activating Factor Receptor Binding and Platelet Aggregation

Molecules, 2010
Phylligenine, together with quebrachitol, stigmasterol and two aporphine alkaloids—oxoputerine and liriodenine—were isolated from the twigs of Mitrephora vulpina C.E.C. Fisch.
Khozirah Shaari, Bushra Abdulkarim Moharam, Juriyati Jalil, Ibrahim Jantan   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Platelet-Activating Factor Promotes the Development of Non-Alcoholic Fatty Liver Disease

Diabetes, Metabolic Syndrome and Obesity, 2022
Hang Yin, Anhua Shi, Junzi Wu Key Laboratory of Microcosmic Syndrome Differentiation, Yunnan University of Chinese Medicine, Kunming, People’s Republic of ChinaCorrespondence: Junzi Wu; Anhua Shi, Key Laboratory of Microcosmic Syndrome Differentiation ...
Yin H, Shi A, Wu J
doaj  

Modulation of inflammatory platelet-activating factor (PAF) receptor by the acyl analogue of PAF

Journal of Lipid Research, 2018
Platelet-activating factor (PAF) is a potent inflammatory mediator that exerts its actions via the single PAF receptor (PAF-R). Cells that biosynthesize alkyl-PAF also make abundant amounts of the less potent PAF analogue acyl-PAF, which competes for PAF-
Vyala Hanumanthareddy Chaithra, Shancy Petsel Jacob, Chikkamenahalli Lakshminarayana Lakshmikanth, Mosale Seetharam Sumanth, Kandahalli Venkataranganayaka Abhilasha, Chu-Huang Chen, Anita Thyagarajan, Ravi P. Sahu, Jeffery Bryant Travers, Thomas M. McIntyre, Kempaiah Kemparaju, Gopal Kedihithlu Marathe   +11 more
doaj   +1 more source

PAR1 Agonists Stimulate APC-Like Endothelial Cytoprotection and Confer Resistance to Thromboinflammatory Injury [PDF]

, 2018
Stimulation of protease-activated receptor 1 (PAR1) on endothelium by activated protein C (APC) is protective in several animal models of disease, and APC has been used clinically in severe sepsis and wound healing.
Aisiku, Omozuanvbo, Ceunynck, Karen De, Chaudhry, Sharjeel A., Dockendorff, Chris, Fitch-Tewfik, Jennifer L., Flaumenhaft, Robert, Higgins, Sarah J., Ingber, Donald E., Jain, Abhishek, Parikh, Samir M., Peters, Christian G.   +10 more
core   +1 more source

Microvesicles and exosomes: new players in metabolic and cardiovascular disease [PDF]

, 2016
The past decade has witnessed an exponential increase in the number of publications referring to extracellular vesicles (EVs). For many years considered to be extracellular debris, EVs are now seen as novel mediators of endocrine signalling via cell-to ...
Charlotte Lawson, Daniel, Derek M Yellon, Gunduz, Headland, Joop, Jorgensen, Jose M Vicencio, Larson, Lobb, Macey, Mesri, Nomura, Pospichalova, Raturi, Scholz, Sean M Davidson, Ueba, Villarroya-Beltri, Vrijsen, Wang, Welton   +21 more
core   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Impact of targeting the platelet-activating factor and its receptor in cancer treatment

Military Medical Research
The lipid mediator platelet-activating factor (PAF) and its receptor (PAFR) signaling play critical roles in a wide range of physiological and pathophysiological conditions, including cancer growth and metastasis.
Kimya Qaderi, Arvin Shahmoradi, Anita Thyagarajan, Ravi P. Sahu   +3 more
doaj   +1 more source

Identification of platelet-activating factor as the inflammatory lipid mediator in CCl4-metabolizing rat liver

Journal of Lipid Research, 2001
Unmitigated oxidative stress is deleterious, as epitomized by CCl4 intoxication. In this well-characterized model of free radical-initiated damage, liver metabolism of CCl4 to CCl3.
Gopal K. Marathe, Kathleen A. Harrison, L. Jackson Roberts, II, Jason D. Morrow, Robert C. Murphy, Larry W. Tjoelker, Stephen M. Prescott, Guy A. Zimmerman, Thomas M. McIntyre   +8 more
doaj   +1 more source