Results 1 to 10 of about 500,127 (414)

Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex [PDF]

Proceedings of the National Academy of Sciences, 2010
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are prototypic growth factors and receptor tyrosine kinases which have critical functions in development. We show that PDGFs share a conserved region in their prodomain sequences which can remain noncovalently associated with the mature cystine-knot growth factor domain after ...
P. Charles Lin, Xiaolin He, Xiaoyan Chen, Heli Liu, Ann Hye Ryong Shim, Pamela J. Focia   +5 more
openaire   +4 more sources

Activation of platelet-derived growth factor receptor alpha contributes to liver fibrosis. [PDF]

PLoS ONE, 2014
Chronic liver injury leads to fibrosis, cirrhosis, and loss of liver function. Liver cirrhosis is the 12th leading cause of death in the United States, and it is the primary risk factor for developing liver cancer.
Brian J Hayes, Kimberly J Riehle, Masami Shimizu-Albergine, Renay L Bauer, Kelly L Hudkins, Fredrik Johansson, Matthew M Yeh, William M Mahoney, Raymond S Yeung, Jean S Campbell   +9 more
doaj   +2 more sources

Thrombin Stimulated Platelet-Derived Exosomes Inhibit Platelet-Derived Growth Factor Receptor-Beta Expression in Vascular Smooth Muscle Cells

Cellular Physiology and Biochemistry, 2016
Background/Aims: It is difficult to predict acute thrombotic cardiovascular events in the clinic. Few studies have reported the presence of plasma exosomes containing microRNAs (miRNAs) in cardiovascular events.
Ming Tan, Hong-Bing Yan, Jian-Nan Li, Wen-Ke Li, Yuan-Yuan Fu, Wen Chen, Zhou Zhou   +6 more
doaj   +2 more sources

6-Methoxy-2-methyl-1-m-tolyl-1H-benzimidazole hemihydrate [PDF]

Acta Crystallographica Section E, 2011
The title compound, C16H16N2O·0.5H2O, is a substituted 1-phenylbenzimidazole, which belongs to the class of ATP-site inhibitors of the platelet-derived growth-factor receptor.
Xu-Bin Fang, Lei Fang, Xu-Ying Liu
doaj   +4 more sources

Prenatal overexpression of platelet-derived growth factor receptor A results in central nervous system hypomyelination. [PDF]

Brain Behav, 2021
Background Platelet‐derived growth factor (PDGF) signaling, through the ligand PDGF‐A and its receptor PDGFRA, is important for the growth and maintenance of oligodendrocyte progenitor cells (OPCs) in the central nervous system (CNS). PDGFRA signaling is
Cardona HJ, Somasundaram A, Crabtree DM, Gadd SL, Becher OJ.   +4 more
europepmc   +2 more sources

High tumor cell platelet-derived growth factor receptor beta expression is associated with shorter survival in malignant pleural epithelioid mesothelioma. [PDF]

J Pathol Clin Res, 2021
Malignant pleural mesothelioma (MPM) has a rich stromal component containing mesenchymal fibroblasts. However, the properties and interplay of MPM tumor cells and their surrounding stromal fibroblasts are poorly characterized.
Ollila H, Paajanen J, Wolff H, Ilonen I, Sutinen E, Välimäki K, Östman A, Anttila S, Kettunen E, Räsänen J, Kallioniemi O, Myllärniemi M, Mäyränpää MI, Pellinen T.   +13 more
europepmc   +2 more sources

Platelet-derived growth factor receptor beta is critical for zebrafish intersegmental vessel formation. [PDF]

PLoS ONE, 2010
Platelet-derived growth factor receptor beta (PDGFRbeta) is a tyrosine kinase receptor known to affect vascular development. The zebrafish is an excellent model to study specific regulators of vascular development, yet the role of PDGF signaling has not ...
Katie M Wiens, Hyuna L Lee, Hiroyuki Shimada, Anthony E Metcalf, Michael Y Chao, Ching-Ling Lien   +5 more
doaj   +6 more sources

MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha. [PDF]

Respir Res, 2021
Background MicroRNA (miR) are small conserved RNA that regulate gene expression post-transcription. Previous genome-wide analysis studies in preterm infants indicate that pathways of miR 219-5p are important in infants with Bronchopulmonary Dysplasia ...
Freeman A, Qiao L, Olave N, Rezonzew G, Gentle S, Halloran B, Pryhuber GS, Gaggar A, Tipple TE, Ambalavanan N, Lal CV.   +10 more
europepmc   +2 more sources

Platelet-derived growth factor receptor β activation and regulation in murine myelofibrosis

Haematologica, 2020
There is prevailing evidence to suggest a decisive role for platelet-derived growth factors (PDGF) and their receptors in primary myelofibrosis. While PDGF receptor β (PDGFRβ) expression is increased in bone marrow stromal cells of patients correlating ...
Frederike Kramer, Jens Dernedde, Artur Mezheyeuski, Rudolf Tauber, Patrick Micke, Kai Kappert   +5 more
doaj   +6 more sources

Platelet derived growth factor receptor β (PDGFRβ) is a host receptor for the human malaria parasite adhesin TRAP. [PDF]

Sci Rep, 2021
Following their inoculation by the bite of an infected Anopheles mosquito, the malaria parasite sporozoite forms travel from the bite site in the skin into the bloodstream, which transports them to the liver. The thrombospondin-related anonymous protein (
Steel RWJ, Vigdorovich V, Dambrauskas N, Wilder BK, Arredondo SA, Goswami D, Kumar S, Carbonetti S, Swearingen KE, Nguyen T, Betz W, Camargo N, Fisher BS, Soden J, Thomas H, Freeth J, Moritz RL, Noah Sather D, Kappe SHI.   +18 more
europepmc   +2 more sources