Results 1 to 10 of about 258,688 (303)

PET imaging of platelet derived growth factor receptor β in lung fibrosis [PDF]

EJNMMI Radiopharmacy and Chemistry
Background Lung diseases such as idiopathic pulmonary fibrosis and acute respiratory distress syndrome (ARDS) are associated with significant morbidity and mortality, with limited treatment options.
Olivia Wegrzyniak, Francesco Lechi, Johanna Rokka, Bogdan Mitran, Bo Zhang, Ulrika Thelander, John Löfblom, Fredrik Y. Frejd, Olle Korsgren, Gaetano Perchiazzi, Jonas Eriksson, Olof Eriksson   +11 more
doaj   +2 more sources

Prenatal overexpression of platelet‐derived growth factor receptor A results in central nervous system hypomyelination [PDF]

Brain and Behavior, 2021
Background Platelet‐derived growth factor (PDGF) signaling, through the ligand PDGF‐A and its receptor PDGFRA, is important for the growth and maintenance of oligodendrocyte progenitor cells (OPCs) in the central nervous system (CNS). PDGFRA signaling is
Herminio Joey Cardona, Agila Somasundaram, Donna M. Crabtree, Samantha L. Gadd, Oren J. Becher   +4 more
doaj   +2 more sources

Essential growth factor receptors for fibroblast homeostasis and activation: Fibroblast Growth Factor Receptor (FGFR), Platelet Derived Growth Factor Receptor (PDGFR), and Transforming Growth Factor β Receptor (TGFβR) [version 2; peer review: 2 approved] [PDF]

F1000Research
Fibroblasts are cells of mesenchymal origin that are found throughout the body. While these cells have several functions, their integral roles include maintaining tissue architecture through the production of key extracellular matrix components, and ...
Matthew B. Buechler, Maye F. Cheng, Faizah S. Abdullah   +2 more
doaj   +2 more sources

MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha [PDF]

Respiratory Research, 2021
Background MicroRNA (miR) are small conserved RNA that regulate gene expression post-transcription. Previous genome-wide analysis studies in preterm infants indicate that pathways of miR 219-5p are important in infants with Bronchopulmonary Dysplasia ...
Amelia Freeman, Luhua Qiao, Nelida Olave, Gabriel Rezonzew, Samuel Gentle, Brian Halloran, Gloria S. Pryhuber, Amit Gaggar, Trent E. Tipple, Namasivayam Ambalavanan, Charitharth Vivek Lal   +10 more
doaj   +2 more sources

Germline Platelet-derived growth factor receptor beta p.R987W pathogenic variant in 2 children with brain tumors. [PDF]

Neurooncol Adv, 2023
Han H, Renzi S, Larouche V, Faury D, Langlois S, Sinnett D, Gomez A, Karamchandani J, Crevier L, Foulkes WD, Jabado N.   +10 more
europepmc   +3 more sources

Identification of potential bioactive phytochemicals for the inhibition of platelet-derived growth factor receptor β: a structure-based approach for cancer therapy. [PDF]

Front Mol Biosci
Habib I, Sulaimani MN, Jairajpuri DS, Hussain A, Mohammad T, Alajmi MF, Shamsi A, Hassan MI.   +7 more
europepmc   +2 more sources

Inhibition and Mechanism of Imatinib on A549 Xenograft Tumor in Nude Mice via PDGF/PDGFR Pathway

Zhongliu Fangzhi Yanjiu, 2023
Objective To investigate the effect of imatinib on the growth of A549 non-small cell lung cancer transplanted tumors and the expression of PDGFB and PDGFRβ proteins in tumor tissues and stroma in nude mice and to explore the underlying tumor suppression ...
XIA Bingtian, HE Fang, SONG Bingxin, WANG Lili, ZHU Tingjun, JIA Yongqing, HU Huixian   +6 more
doaj   +1 more source

Cover to Volume 3 [PDF]

, 2011
The fibroblast mitogen platelet-derived growth factor -BB (PDGF-BB) induces a transient expression of the orphan nuclear receptor NR4A1 (also named Nur77, TR3 or NGFIB).
A Bras, A Jurek, A Ostman, AD Wingate, AD Wingate, AG Smith, AJ Wilson, AN Alexopoulou, AN McEvoy, AV Hinze, B Liu, B You, BX Zhao, Carl-Henrik Heldin, CH Heldin, CO Stocco, D Kovalovsky, D Zhao, EK Arkenbout, EK Arkenbout, F Zhou, Glenda Eger, H Zeng, HG Kasler, J Darragh, J Pontén, J Thompson, JD Woronicz, Johan Lennartsson, K Kondoh, K Yoon, L De Léséleuc, L Fredriksson, L Pei, L Wang, LE Cheng, LJ Martin, M Cargnello, M Sakaue, MA Pearen, MW Maijenburg, Natalia Papadopoulos, Nikos K. Karamanos, Q Wu, S Safe, S Suzuki, SA Kang, SE Mullican, SJ Sohn, SK Kolluri, SK Kolluri, SK To, SO Lee, X Wang, XK Zhang, Y Inaoka, Y Keshet, Y Liu, Y Zhan, YH Han, Z Li, ZG Liu   +61 more
core   +20 more sources

Generation of a PDGFRB-mCherry knock-in reporter human induced pluripotent stem cell line (KITi001-A-1), using CRISPR/Cas9 nuclease

Stem Cell Research, 2023
PDGFRB encodes platelet-derived growth factor receptor beta (PDGFR-β), a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family.
Seongyea Jo, Ji-Woo Kim, Haneul Noh, Hyemin Kim, Jong-Hoon Kim, Han-Jin Park   +5 more
doaj   +1 more source

GDF-15 Inhibits ADP-Induced Human Platelet Aggregation through the GFRAL/RET Signaling Complex

Biomolecules, 2023
Growth differentiation factor-15 (GDF-15) is proposed to be strongly associated with several cardiovascular diseases, such as heart failure and atherosclerosis.
Baikang Xie, Wenjing Tang, Shuang Wen, Fen Chen, Chao Yang, Min Wang, Yong Yang, Wei Liang   +7 more
doaj   +1 more source