Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex [PDF]
Proceedings of the National Academy of Sciences, 2010 Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are prototypic growth factors and receptor tyrosine kinases which have critical functions in development.
Ann Hye-Ryong Shim +5 more
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Activation of platelet-derived growth factor receptor alpha contributes to liver fibrosis. [PDF]
PLoS ONE, 2014 Chronic liver injury leads to fibrosis, cirrhosis, and loss of liver function. Liver cirrhosis is the 12th leading cause of death in the United States, and it is the primary risk factor for developing liver cancer.
Brian J Hayes +9 more
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Cellular Physiology and Biochemistry, 2016 Background/Aims: It is difficult to predict acute thrombotic cardiovascular events in the clinic. Few studies have reported the presence of plasma exosomes containing microRNAs (miRNAs) in cardiovascular events.
Ming Tan +6 more
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Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1988 The complete nucleotide sequence of a cDNA encoding the human platelet-derived growth factor (PDGF) receptor is presented. The cDNA contains an open reading frame that codes for a protein of 1106 amino acids. Comparison to the mouse PDGF receptor reveals
R G Gronwald +8 more
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Prenatal overexpression of platelet‐derived growth factor receptor A results in central nervous system hypomyelination [PDF]
Brain and Behavior, 2021 Background Platelet‐derived growth factor (PDGF) signaling, through the ligand PDGF‐A and its receptor PDGFRA, is important for the growth and maintenance of oligodendrocyte progenitor cells (OPCs) in the central nervous system (CNS). PDGFRA signaling is
Herminio Joey Cardona +4 more
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High tumor cell platelet‐derived growth factor receptor beta expression is associated with shorter survival in malignant pleural epithelioid mesothelioma [PDF]
The Journal of Pathology: Clinical Research, 2021 Malignant pleural mesothelioma (MPM) has a rich stromal component containing mesenchymal fibroblasts. However, the properties and interplay of MPM tumor cells and their surrounding stromal fibroblasts are poorly characterized.
Hely Ollila +13 more
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MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha [PDF]
Respiratory Research, 2021 Background MicroRNA (miR) are small conserved RNA that regulate gene expression post-transcription. Previous genome-wide analysis studies in preterm infants indicate that pathways of miR 219-5p are important in infants with Bronchopulmonary Dysplasia ...
Amelia Freeman +10 more
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Platelet derived growth factor receptor β (PDGFRβ) is a host receptor for the human malaria parasite adhesin TRAP [PDF]
Scientific Reports, 2021 Following their inoculation by the bite of an infected Anopheles mosquito, the malaria parasite sporozoite forms travel from the bite site in the skin into the bloodstream, which transports them to the liver. The thrombospondin-related anonymous protein (
Ryan W. J. Steel +18 more
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Platelet-derived growth factor receptor β activation and regulation in murine myelofibrosis
Haematologica, 2020 There is prevailing evidence to suggest a decisive role for platelet-derived growth factors (PDGF) and their receptors in primary myelofibrosis. While PDGF receptor β (PDGFRβ) expression is increased in bone marrow stromal cells of patients correlating ...
Frederike Kramer +5 more
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Inhibition and Mechanism of Imatinib on A549 Xenograft Tumor in Nude Mice via PDGF/PDGFR Pathway
Zhongliu Fangzhi Yanjiu, 2023 Objective To investigate the effect of imatinib on the growth of A549 non-small cell lung cancer transplanted tumors and the expression of PDGFB and PDGFRβ proteins in tumor tissues and stroma in nude mice and to explore the underlying tumor suppression ...
XIA Bingtian +6 more
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