Effect of Topical Opioid Antagonist on Diabetic Wound Healing in Rat Model
Foot & Ankle Orthopaedics, 2017 Category: Basic Sciences/Biologics, Diabetes Introduction/Purpose: Approximately 50% of the 170 million people worldwide with diabetes experience complications associated with delayed cutaneous wound healing.
Jarrett Cain DPM, MSc +1 more
doaj +1 more source
Retinoic acid promotes transcription of the platelet-derived growth factor alpha-receptor gene. [PDF]
, 1990 Chao Wang +3 more
openalex +1 more source
Accelerated Bone Healing via Electrical Stimulation
Advanced Science, EarlyView.Electrical stimulation significantly impacts bone healing by enhancing osteoblast proliferation, differentiation, and vascularization through calmodulin/calcineurin/NFAT signaling. It also boosts macrophage function and cell migration, presenting a comprehensive approach to accelerating bone repair.
Jianfeng Sun +4 more
wiley +1 more source
Imaging of fibrogenesis in the liver by [18F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β. [PDF]
EJNMMI Radiopharm Chem, 2023 Wegrzyniak O +15 more
europepmc +1 more source
The phenomenon of growing surface interference explains the rosette pattern of jaguar [PDF]
arXiv, 2017 One possible mechanism to explain how animals got their coat patterns was proposed by Alan Turing. He assumed that two kinds of morphogens diffuse on a surface and interact with each other, generating a reaction-diffusion mechanism. We developed a new framework for pattern generation incorporating a non-diffusing transcription factor in the system. The
arxiv
Advanced Science, EarlyView.An unprecedented high‐resolution spatial atlas of the E. multilocularis infection foci is obtained, revealing the dynamic functions of neutrophils, Spp1+ macrophages, and fibroblasts during disease progression. The transition of parasite control strategy from “active killing” to “negative segregation” by the host may provide instructive insights into ...
Zhihua Ou +35 more
wiley +1 more source
The catalytic subunit of phosphatidylinositol 3-kinase is a substrate for the activated platelet-derived growth factor receptor, but not for middle-T antigen-pp60c-src complexes [PDF]
, 1994 Serge Roche +3 more
openalex +1 more source
Advanced Science, EarlyView.Cells transduce the rigidity of the environment into biochemical cues through mechanotransductive cascades that modulate cell behavior. Here, a novel role for the boron transporter NaBC1 is identified as a mechanotransducer involved in regulating cell behavior via specific crosstalk with fibronectin‐binding integrins.
Juan Gonzalez‐Valdivieso +9 more
wiley +1 more source
Advanced Science, EarlyView.Traditional Chinese Medicine (TCM), while holistic and historically esteemed, faces challenges in “miracle cures” due to slow onset, long cycles, and difficulty controlling quality. This study obtains the active ingredients, glabridin (GLA) and puerarin (PUE), from Ge‐Gen Decoction (GGD), developing a safe and effective drug delivery system, GLA‐PUE ...
Jianhong Qi +7 more
wiley +1 more source
Using GANs for De Novo Protein Design Targeting Microglial IL-3R$α$ to Inhibit Alzheimer's Progression [PDF]
arXivIL-3 is a hemopoietic growth factor that usually targets blood cell precursors; IL-3R is a cytokine receptor that binds to IL-3. However, IL-3 takes on a different role in the context of glial cells in the nervous system, where studies show that the protein IL-3 protects against Alzheimer's disease by activating microglia at their IL-3R receptors ...
arxiv