Results 141 to 150 of about 334,171 (270)

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

Advanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong, Pei Li, Yi Jiang, Zhihan Wang, Shihui Fu, Hebin Che, Meng Liu, Xiaojing Zhao, Chunlei Liu, Chenghui Zhao, Qin Zhong, Chongyou Rao, Siwei Wang, Suyuan Liu, Dayu Hu, Dongjin Wang, Juntao Gao, Kai Guo, Xinwang Liu, En Zhu, Kunlun He   +20 more
wiley   +1 more source

Distributions of Platelet-Derived Growth Factor Receptor-α Positive Cells and Interstitial Cells of Cajal in the Colon of Rats with Diabetes Mellitus Type 2. [PDF]

Medicina (Kaunas), 2023
Veličkov AI, Djordjević B, Lazarević M, Veličkov AV, Petrović V, Jović M, Denčić T, Radenković G.   +7 more
europepmc   +1 more source

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source

Myeloproliferative neoplasm with basophilia and abnormality of platelet-derived growth factor receptor a translocation: a case report. [PDF]

Blood Res, 2022
Choi JG, Cho DY.
europepmc   +1 more source

Platelet-derived growth factor-mediated Ca2+ entry is blocked by antibodies to phosphatidylinositol 4,5-bisphosphate but does not involve heparin-sensitive inositol 1,4,5-trisphosphate receptors

, 1991
Chou-Long Huang, Tadafumi Takenawa, Harlan E. Ives   +2 more
openalex   +1 more source

Down-regulation of cellular platelet-derived growth factor receptors induced by an activated neu receptor tyrosine kinase. [PDF]

, 1991
Laura Lehtola, Monica Nistér, Erkki Hölttä, Bengt Westermark, Kari Alitalo   +4 more
openalex   +1 more source

Integrating Protein Sequence and Expression Level to Analysis Molecular Characterization of Breast Cancer Subtypes [PDF]

arXiv
Breast cancer's complexity and variability pose significant challenges in understanding its progression and guiding effective treatment. This study aims to integrate protein sequence data with expression levels to improve the molecular characterization of breast cancer subtypes and predict clinical outcomes.
arxiv  

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
wiley   +1 more source

Type H vessel/platelet-derived growth factor receptor β⁺ perivascular cell disintegration is involved in vascular injury and bone loss in radiation-induced bone damage. [PDF]

Cell Prolif, 2023
Li J, Chen X, Ren L, Chen X, Wu T, Wang Y, Ren X, Cheng B, Xia J.   +8 more
europepmc   +1 more source

Platelet-derived Growth Factor Induces a Long-term Inhibition of -Methyl-D-aspartate Receptor Function [PDF]

, 1996
C. Fernando Valenzuela, Zhi‐Gang Xiong, John F. MacDonald, Jeff L. Weiner, Charles J. Frazier, Thomas V. Dunwiddie, Andrius Kazlauskas, Paul J. Whiting, R. Adron Harris   +8 more
openalex   +1 more source