Inhibition and Mechanism of Imatinib on A549 Xenograft Tumor in Nude Mice via PDGF/PDGFR Pathway
Zhongliu Fangzhi Yanjiu, 2023 Objective To investigate the effect of imatinib on the growth of A549 non-small cell lung cancer transplanted tumors and the expression of PDGFB and PDGFRβ proteins in tumor tissues and stroma in nude mice and to explore the underlying tumor suppression ...
XIA Bingtian +6 more
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Platelet-derived Growth Factors and Receptors in Canine Lymphoma [PDF]
Journal of Comparative Pathology, 2014 Platelet-derived growth factors (PDGFs) belong to a family of polypeptide growth factors that signal through cell surface tyrosine kinase receptors to stimulate growth, proliferation and differentiation. Platelet-derived growth factor receptors (PDGFRs) are also considered important targets for specific kinase inhibitors in the treatment of several ...
ARICO', ARIANNA +8 more
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GDF-15 Inhibits ADP-Induced Human Platelet Aggregation through the GFRAL/RET Signaling Complex
Biomolecules, 2023 Growth differentiation factor-15 (GDF-15) is proposed to be strongly associated with several cardiovascular diseases, such as heart failure and atherosclerosis.
Baikang Xie +7 more
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Platelet-Derived Growth Factor Receptor
Definitions, 2020 A cell surface protein that has tyrosine-kinase activity. This receptor specifically binds to platelet derived growth factor, and its analogs and antagonists. Ligand binding causes homodimerization or heterodimerization, resulting in receptor activation.
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Platelet-Derived Growth Factor Receptor Beta
Definitions, 2020 Platelet-derived growth factor receptor beta (1106 aa, ~124 kDa) is encoded by the human PDGFRB gene. This protein plays a role in tyrosine phosphorylation and ligand-dependent signal transduction.
semanticscholar +1 more source
Pulmonary Circulation, 2020 Platelet-derived growth factor is one of the major growth factors found in human and mammalian serum and tissues. Abnormal activation of platelet-derived growth factor signaling pathway through platelet-derived growth factor receptors may contribute to ...
Kang Wu +21 more
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Calmodulin prevents activation of Ras by PKC in 3T3 fibroblasts [PDF]
, 2021 We have shown previously (Villalonga, P., López- Alcalá, C., Bosch, M., Chiloeches, A., Rocamora, N., Gil, J., Marais, R., Marshall, C. J., Bachs, O., and Agell, N. (2001) Mol. Cell. Biol.
Agell i Jané, Neus +6 more
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Dissociation of the ligand and dephosphorylation of the platelet‐derived growth factor receptor [PDF]
FEBS Letters, 1988 The ligand‐induced phosphorylation of the platelet‐derived growth factor (PDGF) receptor was followed at 37°C by a rapid dephosphorylation which was roughly parallel to the down regulation of the 125I‐PDGF binding sites. At 4°C, when the ligand‐receptor complexes remain associated with the cell surface, the phosphorylated form of the receptor was more ...
Sturani E +4 more
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Low Mr phosphotyrosine protein phosphatase activity on fibroblast growth factor receptor is not associated with enzyme translocation [PDF]
, 1999 Fibroblast growth factor receptor (class IV) shares a certain degree of similarity with class III members like platelet-derived growth factor and macrophage-colony-stimulating factor receptors, which, once activated, are substrates of low Mr ...
Bagnoli, Silvia +4 more
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Alveolar fluid in acute respiratory distress syndrome promotes fibroblast migration: role of platelet-derived growth factor pathway [PDF]
, 2012 OBJECTIVES: Fibroblast migration is an initiating step in fibroproliferation; its involvement during acute lung injury and acute respiratory distress syndrome remains poorly understood. The aims of this study were: 1) to determine whether bronchoalveolar
A. Mailleux +10 more
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