Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex [PDF]
Proceedings of the National Academy of Sciences, 2010 Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are prototypic growth factors and receptor tyrosine kinases which have critical functions in development. We show that PDGFs share a conserved region in their prodomain sequences which can remain noncovalently associated with the mature cystine-knot growth factor domain after ...
P. Charles Lin +5 more
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Activation of platelet-derived growth factor receptor alpha contributes to liver fibrosis. [PDF]
PLoS ONE, 2014 Chronic liver injury leads to fibrosis, cirrhosis, and loss of liver function. Liver cirrhosis is the 12th leading cause of death in the United States, and it is the primary risk factor for developing liver cancer.
Brian J Hayes +9 more
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Cellular Physiology and Biochemistry, 2016 Background/Aims: It is difficult to predict acute thrombotic cardiovascular events in the clinic. Few studies have reported the presence of plasma exosomes containing microRNAs (miRNAs) in cardiovascular events.
Ming Tan +6 more
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Platelet-derived growth factor receptor β activation and regulation in murine myelofibrosis
Haematologica, 2020 There is prevailing evidence to suggest a decisive role for platelet-derived growth factors (PDGF) and their receptors in primary myelofibrosis. While PDGF receptor β (PDGFRβ) expression is increased in bone marrow stromal cells of patients correlating ...
Frederike Kramer +5 more
doaj +6 more sources
Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1988 R G Gronwald +8 more
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Platelet-derived Growth Factors and Receptors in Canine Lymphoma [PDF]
Journal of Comparative Pathology, 2014 Platelet-derived growth factors (PDGFs) belong to a family of polypeptide growth factors that signal through cell surface tyrosine kinase receptors to stimulate growth, proliferation and differentiation. Platelet-derived growth factor receptors (PDGFRs) are also considered important targets for specific kinase inhibitors in the treatment of several ...
ARICO', ARIANNA +8 more
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Platelet-Derived Growth Factor Receptor
Definitions, 2020 A cell surface protein that has tyrosine-kinase activity. This receptor specifically binds to platelet derived growth factor, and its analogs and antagonists. Ligand binding causes homodimerization or heterodimerization, resulting in receptor activation.
semanticscholar +1 more source
Platelet-Derived Growth Factor Receptor Beta
Definitions, 2020 Platelet-derived growth factor receptor beta (1106 aa, ~124 kDa) is encoded by the human PDGFRB gene. This protein plays a role in tyrosine phosphorylation and ligand-dependent signal transduction.
semanticscholar +1 more source
Dissociation of the ligand and dephosphorylation of the platelet‐derived growth factor receptor [PDF]
FEBS Letters, 1988 The ligand‐induced phosphorylation of the platelet‐derived growth factor (PDGF) receptor was followed at 37°C by a rapid dephosphorylation which was roughly parallel to the down regulation of the 125I‐PDGF binding sites. At 4°C, when the ligand‐receptor complexes remain associated with the cell surface, the phosphorylated form of the receptor was more ...
Sturani E +4 more
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Platelet-Derived Growth Factor Receptor Association with Na+/H+ Exchanger Regulatory Factor Potentiates Receptor Activity [PDF]
Molecular and Cellular Biology, 2000 Platelet-derived growth factor (PDGF) is a potent mitogen for many cell types. The PDGF receptor (PDGFR) is a receptor tyrosine kinase that mediates the mitogenic effects of PDGF by binding to and/or phosphorylating a variety of intracellular signaling ...
Stuart Maudsley +6 more
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