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Platelet-Derived Growth Factor Activates Porcine Thecal Cell Phosphatidylinositol-3-Kinase-Akt/PKB and Ras-Extracellular Signal-Regulated Kinase-1/2 Kinase Signaling Pathways via the Platelet-Derived Growth Factor-β Receptor¹

, 2000
Christopher Taylor
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Regulation of chemotaxis by the platelet-derived growth factor receptor-β

Nature, 1994
Chemotaxis is an important component of wound healing, development, immunity and metastasis, yet the signalling pathways that mediate chemotaxis are poorly understood. Platelet-derived growth factor (PDGF) acts both as a mitogen and a chemoattractant. Upon stimulation, the tyrosine kinase PDGF receptor-beta (PDGFR-beta) autophosphorylates and forms a ...
Sue Goo Rhee, Vikas Kundra, Bruce R. Zetter, Jaime Escobedo, Ha Kun Kim, Lewis T. Williams, Andrius Kazlauskas   +6 more
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Role of Platelet-Derived Growth Factor/Platelet-Derived Growth Factor Receptor Axis in the Trafficking of Circulating Fibrocytes in Pulmonary Fibrosis

American Journal of Respiratory Cell and Molecular Biology, 2014
Circulating fibrocytes have been reported to migrate into the injured lungs, and contribute to fibrogenesis via CXCL12-CXCR4 axis. In contrast, we report that imatinib mesylate prevented bleomycin (BLM)-induced pulmonary fibrosis in mice by inhibiting platelet-derived growth factor receptor (PDGFR), even when it was administered only in the early phase.
Keisuke Izumi, Yasuhiko Nishioka, Jun Kishi, Yoshinori Aono, Seidai Sato, Masami Kishi, Yuki Yokota, Momoyo Azuma, Hisanori Uehara, Hiroshi Kawano, Katsuhiro Kinoshita, Hisatsugu Goto, Akio Takezaki   +12 more
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Platelet-Derived Growth Factor

Definitions, 2020
A family of growth factors that act as potent mitogens and are involved in the stimulation of angiogenesis. There are four members of this family (platelet-derived growth factor A, B, C and D) that are characterized by a core motif of eight cysteines ...

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Expression of platelet‐derived growth factor‐AA and platelet‐derived growth factor‐α receptor in ameloblastomas

Journal of Oral Pathology & Medicine, 2008
Background:  Platelet‐derived growth factor (PDGF)‐AA isoform and its receptor, PDGF‐α receptor (PDGFRA) regulate tooth development and growth. We investigated the expression of both proteins in ameloblastomas, to contribute the understanding of the potential role of the PDGF/PDGFR system in this odontogenic neoplasm.Method:  Twenty‐nine specimens of ...
Nikolaus Wick, Peter R. Mazal, Irene Sulzbacher, Bettina Pichlhofer   +3 more
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Signal Transduction by the Platelet-Derived Growth Factor Receptor [PDF]

Science, 1989
When platelet-derived growth factor (PDGF) binds to its receptor on a quiescent fibroblast or smooth muscle cell, it stimulates a remarkably diverse group of biochemical responses, including changes in ion fluxes, activation of several kinases, alterations in cell shape, increased transcription of a number of genes, and stimulation of enzymes that ...
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Commentary Signal transduction by the receptors for platelet-derived growth factor

Journal of Cell Science, 1990
ABSTRACT Platelet-derived growth factor CPDGF) is a connective tissue cell mitogen that originally was purified from human platelets, but recently has been found to be produced by many different cell types (reviewed by Ross et al. 1986; Heldin and Westermark, 1989). The in vivo function of PDGF remains speculative, but the fact that PDGF
Westermark B, C H Heldin
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