Results 201 to 210 of about 191,742 (248)
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Journal of Dermatological Science, 1998
Scleroderma is a fibrotic disease occurring in a localized or systemic form. The pathogenesis of scleroderma remains poorly understood. Recent studies revealed that various cytokines and growth factors were involved in the development of scleroderma fibrosis.
Zhang Jian-zhong +3 more
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Scleroderma is a fibrotic disease occurring in a localized or systemic form. The pathogenesis of scleroderma remains poorly understood. Recent studies revealed that various cytokines and growth factors were involved in the development of scleroderma fibrosis.
Zhang Jian-zhong +3 more
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Platelet derived growth factor and its receptor in intracerebral hemorrhage
Journal of Zhejiang University (Medical Sciences), 2022Intracerebral hemorrhage (ICH) is a common and highly disabling or fatal neurological disorder in adults. Recent studies have suggested that the platelet derived growth factor (PDGF) signaling pathway plays an important role in the development of ICH. PDGF is involved in vascular remodeling and can be used as a biomarker of cerebral amyloid angiopathy ...
Baojie, Mao, Ming, Wang, Shu, Wan
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The platelet-derived growth factor receptor as a therapeutic target
Current Oncology Reports, 2007Several small molecule tyrosine kinase inhibitors that block the epidermal growth factor receptor and vascular endothelial growth factor receptor function are among the many recently developed targeted anticancer therapeutic agents. Increasing evidence indicates that inhibition of other tumor stromal targets could provide additional and possibly ...
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[8] methods for studying the platelet-derived growth factor receptor
1985Publisher Summary This chapter discusses the factors that affect [ 125 I] platelet-derived growth factory (PDGF) binding, or the evaluation of binding, on the evidence that the observed binding is to a functional receptor and on the development of a radioreceptor assay for PDGF. It is a basic 30,000-dalton protein.
Daniel F. Bowen-Pope, Russell Ross
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Molecular Pharmacology, 2001
The ability of dopamine D(4) and D(2) receptors to activate extracellular signal-regulated kinases (ERKs) 1 and 2 was compared using Chinese hamster ovary (CHO-K1) cells transfected with D(4.2), D(4.4), D(4.7), and D(2L) receptors.
J. Oak, N. Lavine, H. V. Tol
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The ability of dopamine D(4) and D(2) receptors to activate extracellular signal-regulated kinases (ERKs) 1 and 2 was compared using Chinese hamster ovary (CHO-K1) cells transfected with D(4.2), D(4.4), D(4.7), and D(2L) receptors.
J. Oak, N. Lavine, H. V. Tol
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Structural and functional aspects of the receptors for platelet-derived growth factor
Progress in Growth Factor Research, 1989Platelet-derived growth factor (PDGF) is a 30 kDa dimer of disulfide-bonded A and B chains. Three isoforms of PDGF have been isolated (PDGF-AA, PDGF-AB and PDGF-BB). These bind with different affinities and specificities to two structurally related cell surface receptors, viz. the alpha-receptor and the beta-receptor.
Lena Claesson-Welsh +2 more
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Signal transduction via platelet-derived growth factor receptors
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1998Platelet-derived growth factor (PDGF) exerts its stimulatory effects on cell growth and motility by binding to two related protein tyrosine kinase receptors. Ligand binding induces receptor dimerization and autophosphorylation, allowing binding and activation of cytoplasmic SH2-domain containing signal transduction molecules.
Arne Östman +2 more
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Caveolin Is an Inhibitor of Platelet-Derived Growth Factor Receptor Signaling
Experimental Cell Research, 1999Caveolin is a major structural component of caveolae and has been implicated in the regulation of the function of several caveolae-associated signaling molecules. Platelet-derived growth factor (PDGF) receptors and caveolin were colocalized in the same subcellular fraction after sucrose density gradient fractionation of fibroblasts.
Yoshihiro Ishikawa +3 more
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Current Opinion in Nephrology and Hypertension, 2004
The phenotypic consequences of null mutations in the platelet-derived growth factor-B and the platelet-derived growth factor beta-receptor genes in mice have demonstrated that these proteins play pivotal roles in the development of the vascular smooth muscle cell lineage, including pericytes and mesangial cells.The lethality of these mutants has ...
Maria Enge +5 more
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The phenotypic consequences of null mutations in the platelet-derived growth factor-B and the platelet-derived growth factor beta-receptor genes in mice have demonstrated that these proteins play pivotal roles in the development of the vascular smooth muscle cell lineage, including pericytes and mesangial cells.The lethality of these mutants has ...
Maria Enge +5 more
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Receptors for platelet-derived growth factor on microvascular endothelial cells
1992Endothelial cells are widely thought to be unresponsive to platelet-derived growth factor (PDGF) and devoid of PDGF receptors. However, in examining the growth factor responses of microvascular endothelial cells isolated from human omental adipose tissue, we detected PDGF-induced tyrosine phosphorylation of an 180-kD glycoprotein, subsequently ...
Frackelton Ar +3 more
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