Results 211 to 220 of about 191,742 (248)

Platelet-Derived Growth Factor B Type Receptor

1990
Platelet-derived growth factor (PDGF) is a major mitogen in serum for connective tissue cells (for reviews, see Heldin et al., 1985; Ross et al., 1986). The in vivo function of PDGF is not known. However, the fact that PDGF is released from platelets in conjunction with the blood coagulation and stimulates not only proliferation, but also chemotaxis ...
Lars Rönnstrand, Carl-Henrik Heldin
openaire   +2 more sources

Modulation of Epidermal Growth Factor Receptors on 3T3 Cells by Platelet-Derived Growth Factor

Science, 1980
Platelet-derived growth factor does not compete with epidermal growth factor (EGF) for binding to EGF receptors on the murine 3T3 cell surface, but it modulates EGF receptors in two ways: (i) it induces a transient down regulation of EGF receptors and (ii) it inhibits EGF-induced down regulation of EGF receptors.
CF Fox, M Wrann, Russell Ross
openaire   +3 more sources

Enhanced Expression of Platelet-Derived Growth Factor-β Receptor by High Glucose Involvement of Platelet-Derived Growth Factor in Diabetic Angiopathy

Diabetes, 1996
Coronary heart disease is a major complication of diabetic subjects, and platelet-derived growth factor (PDGF) has been implicated in the development of atherosclerosis. We investigated the effects of high glucose on expression of PDGF-β receptor. In a binding assay with 125I-labeled PDGF-BB homodimer, high concentrations of glucose increased high ...
Noritsugu Morino, Yoshio Yazaki, Toshimori Inaba, Masanobu Kawakami, N. Yamada, Takanari Gotoda, Shun Ishibashi, Yoshihisa Nojima, Masako Kawamura   +8 more
openaire   +3 more sources

Role of KIT and platelet-derived growth factor receptors as oncoproteins

Seminars in Oncology, 2004
KIT and platelet-derived growth factor receptors (PDGFRs) play critical oncogenic roles in a broad spectrum of hematologic and solid tumors. These receptor tyrosine kinases, as well as ABL and BCR-ABL, are inhibited by imatinib. Tumors caused by chromosomal translocations that lead to overexpression of PDGFR ligand, resulting in continuous activation ...
openaire   +3 more sources

The Platelet-Derived Growth Factor Receptor

International Journal of Neuroscience, 1985
Michael E. Rosenfeld, Russell Ross, Ronald A. Seifert, Daniel F. Bowen-Pope   +3 more
openaire   +5 more sources

Fibroblast Growth Factor Receptor and Platelet-Derived Growth Factor Receptor Abnormalities in Eosinophilic Myeloproliferative Disorders

Acta Haematologica, 2008
Rearrangements of the genes encoding the fibroblast growth factor receptor 1 (FGFR1) and platelet-derived growth factor receptors (PDGFR) α or β receptor tyrosine kinases are found in a rare but important subset of patients with atypical myeloproliferative disorders that are usually but not always associated with eosinophilia.
Cross, N.C., Reiter, A.
openaire   +4 more sources

Receptors | Platelet-Derived Growth Factor Receptor Family

Encyclopedia of Biological Chemistry III, 2021
M. Kovalenko, A. Kazlauskas, Vivian Kitainda   +2 more
semanticscholar   +1 more source

Platelet-derived growth factor receptor (PDGFR): A target for anticancer therapeutics

Drug Resistance Updates, 2005
Platelet-derived growth factors (PDGFs) and their tyrosine kinase receptors (PDGFRs) have been implicated in the pathogenesis of a number of tumor types and play an important role in angiogenesis. Tumor growth can be promoted by PDGF via autocrine stimulation of malignant cells, by overexpression or overactivation of PDGFRs, or by stimulation of ...
Board, Ruth, Jayson, Gordon C.
openaire   +4 more sources

Mechanism of action and in vivo role of platelet-derived growth factor.

Physiological Reviews, 1999
C. Heldin, B. Westermark
semanticscholar   +1 more source

The role of small molecule platelet-derived growth factor receptor (PDGFR) inhibitors in the treatment of neoplastic disorders.

Pharmacological Research, 2018
R. Roskoski
semanticscholar   +1 more source