Results 21 to 30 of about 191,742 (248)

Anti-Angiogenic Treatment (Sunitinib) for Disseminated Malignant Haemangiopericytoma: A Case Study and Review of the Literature

Case Reports in Oncology, 2011
Introduction: A meningeal haemangiopericytoma (HP) is a mesenchymal tumour that makes up less than 1% of all CNS tumours. HPs arise from pericytes and present high rates of recurrence and distant metastasis. The primary treatment option is surgery.
M. Delgado, E. Pérez-Ruiz, J. Alcalde, D. Pérez, R. Villatoro, A. Rueda   +5 more
doaj   +1 more source

Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-β signaling

PLoS ONE, 2017
Pericytes regulate key neurovascular functions of the brain. Studies in pericyte-deficient transgenic mice with aberrant signaling between endothelial-derived platelet-derived growth factor BB (PDGF-BB) and platelet-derived growth factor receptor β ...
A. Nikolakopoulou, Zhen Zhao, Axel Montagne, B. Zlokovic   +3 more
semanticscholar   +1 more source

PDGFRα promoter polymorphisms and expression patterns influence risk of development of imatinib-induced thrombocytopenia in chronic myeloid leukemia: A study from India

Tumor Biology, 2017
Platelet-derived growth factor receptor has been implicated in many malignant and non-malignant diseases. Platelet-derived growth factor receptor-α is a tyrosine kinase and a side target for imatinib, a revolutionary drug for the treatment of chronic ...
Sameer Ahmad Guru, Rashid Mir, Musadiq Bhat, Imtiyaz Najar, Mariyam Zuberi, Mamta Sumi, Mirza Masroor, Naresh Gupta, Alpana Saxena   +8 more
doaj   +1 more source

Artificial Control of Subtype-Specific Platelet-Derived Growth Factor– Receptor Signaling

Journal of Pharmacological Sciences, 2009
Platelet-derived growth factor (PDGF) signaling controls various physiological functions via two receptor subtypes: PDGF receptor (PDGFR) α and PDGFRβ. Nevertheless, our understanding of their roles is limited because of a lack of pharmacological tools ...
Masayuki Isa, Yusaku Ohta, Shigeyuki Namiki, Kenzo Hirose   +3 more
doaj   +1 more source

A derivative of platelet-derived growth factor receptor alpha binds to the trimer of human cytomegalovirus and inhibits entry into fibroblasts and endothelial cells

PLoS Pathogens, 2017
Human cytomegalovirus (HCMV) is a widely distributed herpesvirus that causes significant morbidity in immunocompromised hosts. Inhibitors of viral DNA replication are available, but adverse effects limit their use.
Cora Stegmann, Daniel Hochdorfer, Diana Lieber, Narmadha Subramanian, Dagmar Stöhr, Kerstin Laib Sampaio, C. Sinzger   +6 more
semanticscholar   +1 more source

Platelet-Derived Growth Factor (PDGF)/PDGF Receptors (PDGFR) Axis as Target for Antitumor and Antiangiogenic Therapy

Pharmaceuticals, 2010
Angiogenesis in normal and pathological conditions is a multi-step process governed by positive and negative endogenous regulators. Many growth factors are involved in different steps of angiogenesis, like vascular endothelial growth factors (VEGF ...
Anca Maria Cimpean, Marius Raica
doaj   +1 more source

AFC1 Compound Attenuated MI/R-Induced Ventricular Remodeling via Inhibiting PDGFR and STAT Pathway

Frontiers in Pharmacology, 2019
Background: Effective interventions to improve the outcome of patients subjected to myocardial ischemia reperfusion (MI/R) are urgent in clinical settings. Tanshinone IIA (TSA) is reported to attenuate myocardial injury and improve ventricular remodeling
Jie Liu, Jie Liu, Xiaohui Zhou, Xiaohui Zhou, Qingshu Meng, Qingshu Meng, Kevin W. Huang, Jing Liu, Jing Liu, Jinjun Tie, Jinjun Tie, Rulin Zhuang, Rulin Zhuang, Guohan Chen, Yuhui Zhang, Lu Wei, Lu Wei, Li Huang, Chun Guang Li, Binghui Wang, Binghui Wang, Huimin Fan, Huimin Fan, Huimin Fan, Huimin Fan, Zhongmin Liu, Zhongmin Liu, Zhongmin Liu, Zhongmin Liu   +28 more
doaj   +1 more source

High tumor cell platelet‐derived growth factor receptor beta expression is associated with shorter survival in malignant pleural epithelioid mesothelioma

The Journal of Pathology: Clinical Research, 2021
Malignant pleural mesothelioma (MPM) has a rich stromal component containing mesenchymal fibroblasts. However, the properties and interplay of MPM tumor cells and their surrounding stromal fibroblasts are poorly characterized.
Hely Ollila, Juuso Paajanen, Henrik Wolff, Ilkka Ilonen, Eva Sutinen, Katja Välimäki, Arne Östman, Sisko Anttila, Eeva Kettunen, Jari Räsänen, Olli Kallioniemi, Marjukka Myllärniemi, Mikko I Mäyränpää, Teijo Pellinen   +13 more
doaj   +1 more source

Platelet-derived growth factor. III. Identification of a platelet-derived growth factor receptor by affinity labeling.

Journal of Biological Chemistry, 1982
Two homobifunctional cross-linking reagents have been used to cross-link 125I-platelet-derived growth factor (PDGF) to a cell surface component with an approximate Mr = 164,000 that has many characteristics of a specific PDGF receptor. Excess unlabeled PDGF competed for labeling of this component, while high concentrations of fibroblast growth factor ...
K Glenn, D F Bowen-Pope, Russell Ross
openaire   +3 more sources

Involvement of platelet‐derived growth factor ligands and receptors in tumorigenesis [PDF]

Journal of Internal Medicine, 2017
AbstractPlatelet‐derived growth factor (PDGF) isoforms and their receptors have important roles during embryogenesis, particularly in the development of various mesenchymal cell types in different organs. In the adult, PDGF stimulates wound healing and regulates tissue homeostasis.
Carl-Henrik Heldin, Carl-Henrik Heldin, Bengt Westermark, Johan Lennartsson, Johan Lennartsson   +4 more
openaire   +3 more sources