Results 21 to 30 of about 500,127 (414)

Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma.

Journal of Clinical Oncology, 2006
PURPOSE Renal cell carcinoma (RCC) is characterized by loss of von Hippel Lindau tumor suppressor gene activity, resulting in high expression of pro-angiogenic growth factors: vascular endothelial growth factor (VEGF) and platelet-derived growth factor ...
R. Motzer, M. Michaelson, B. Redman, G. Hudes, G. Wilding, R. Figlin, M. Ginsberg, Sindy T. Kim, C. Baum, S. Deprimo, Jim Z. Li, C. Bello, C. Theuer, D. George, B. Rini   +14 more
semanticscholar   +1 more source

Platelet-derived growth factor enhances platelet recovery in a murine model of radiation-induced thrombocytopenia and reduces apoptosis in megakaryocytes via its receptors and the PI3-k/Akt pathway

Haematologica, 2010
Background Platelet-derived growth factor is involved in the regulation of hematopoiesis. Imatinib mesylate, a platelet-derived growth factor receptor inhibitor, induces thrombocytopenia in a significant proportion of patients with chronic myeloid ...
Jie Yu Ye, Godfrey Chi Fung Chan, Liang Qiao, Qizhou Lian, Fan Yi Meng, Xue Qun Luo, Levon M. Khachigian, Ming Ma, Ruixia Deng, Jian Liang Chen, Beng H. Chong, Mo Yang   +11 more
doaj   +1 more source

Gene expression-based screening for inhibitors of PDGFR signaling [PDF]

, 2008
Inhibitors of the platelet derived growth factor receptor (PDGFR) signaling pathway are isolated using gene expression-based high-throughput screening (GE-HTS), a method that is applicable to other ...
Antipova, Alena A, Golub, Todd R, Stockwell, Brent R   +2 more
core   +3 more sources

Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-β signaling

PLoS ONE, 2017
Pericytes regulate key neurovascular functions of the brain. Studies in pericyte-deficient transgenic mice with aberrant signaling between endothelial-derived platelet-derived growth factor BB (PDGF-BB) and platelet-derived growth factor receptor β ...
A. Nikolakopoulou, Zhen Zhao, Axel Montagne, B. Zlokovic   +3 more
semanticscholar   +1 more source

The impact of high density receptor clusters on VEGF signaling [PDF]

EPTCS 125, 2013, pp. 37-52, 2013
Vascular endothelial growth factor (VEGF) signaling is involved in the process of blood vessel development and maintenance. Signaling is initiated by binding of the bivalent VEGF ligand to the membrane-bound receptors (VEGFR), which in turn stimulates receptor dimerization.
arxiv   +1 more source

Anti-Angiogenic Treatment (Sunitinib) for Disseminated Malignant Haemangiopericytoma: A Case Study and Review of the Literature

Case Reports in Oncology, 2011
Introduction: A meningeal haemangiopericytoma (HP) is a mesenchymal tumour that makes up less than 1% of all CNS tumours. HPs arise from pericytes and present high rates of recurrence and distant metastasis. The primary treatment option is surgery.
M. Delgado, E. Pérez-Ruiz, J. Alcalde, D. Pérez, R. Villatoro, A. Rueda   +5 more
doaj   +1 more source

A derivative of platelet-derived growth factor receptor alpha binds to the trimer of human cytomegalovirus and inhibits entry into fibroblasts and endothelial cells

PLoS Pathogens, 2017
Human cytomegalovirus (HCMV) is a widely distributed herpesvirus that causes significant morbidity in immunocompromised hosts. Inhibitors of viral DNA replication are available, but adverse effects limit their use.
Cora Stegmann, Daniel Hochdorfer, Diana Lieber, Narmadha Subramanian, Dagmar Stöhr, Kerstin Laib Sampaio, C. Sinzger   +6 more
semanticscholar   +1 more source

Cargo binding promotes KDEL receptor clustering at the mammalian cell surface [PDF]

Sci. Rep. 6, 28940, 2016, 2017
Transmembrane receptor clustering is a ubiquitous phenomenon in pro- and eukaryotic cells to physically sense receptor/ligand interactions and subsequently translate an exogenous signal into a cellular response. Despite that receptor cluster formation has been described for a wide variety of receptors, ranging from chemotactic receptors in bacteria to ...
arxiv   +1 more source

PDGFRα promoter polymorphisms and expression patterns influence risk of development of imatinib-induced thrombocytopenia in chronic myeloid leukemia: A study from India

Tumor Biology, 2017
Platelet-derived growth factor receptor has been implicated in many malignant and non-malignant diseases. Platelet-derived growth factor receptor-α is a tyrosine kinase and a side target for imatinib, a revolutionary drug for the treatment of chronic ...
Sameer Ahmad Guru, Rashid Mir, Musadiq Bhat, Imtiyaz Najar, Mariyam Zuberi, Mamta Sumi, Mirza Masroor, Naresh Gupta, Alpana Saxena   +8 more
doaj   +1 more source

Transcriptional Regulation of the Platelet-Derived Growth Factor B-receptor by p53 Family Members [PDF]

, 2008
Aims: The platelet-derived growth factor β-receptor (PDGFRB) is critically involved in embryonic development and has a role in many diseases. In cells, signaling through PDGFRB affects growth, migration and death.
Wetterskog, Daniel
core   +1 more source