Results 21 to 30 of about 126,363 (161)
Platelets, 2022 CIGB-247 is a vascular endothelial growth factor (VEGF)-based active immunotherapy and it is currently under investigation for cancer treatment. This specific active immunotherapy encompasses two vaccine candidates that use a human VEGF variant molecule ...
Javier Sánchez Ramírez +3 more
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Frontiers in Endocrinology, 2022 Receptor tyrosine kinases (RTKs) serve as transmembrane receptors that participate in a broad spectrum of cellular processes including cellular growth, motility, differentiation, proliferation, and metabolism. Hence, elucidating the regulatory mechanisms
Rong Tang +2 more
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Stage specific requirement of platelet-derived growth factor receptor-α in embryonic development. [PDF]
PLoS ONE, 2017 Platelet-derived growth factor receptor alpha (PDGFRα) is a cell-surface receptor tyrosine kinase for platelet-derived growth factors. Correct timing and level of Pdgfra expression is crucial for embryo development, and deletion of Pdgfra caused ...
Chen Qian +7 more
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Safety and Efficacy of Sunitinib in Patients with Unresectable Pancreatic Neuroendocrine Tumors
Clinical Medicine Insights: Oncology, 2012 Pancreatic neuroendocrine tumors (PNETs) are becoming increasingly common, with the majority of patients presenting with either lymph node involvement or metastatic disease, thus requiring systemic therapy.
Marcus W. Wiedmann, Joachim Mössner
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Platelet-derived growth factor receptor beta is critical for zebrafish intersegmental vessel formation. [PDF]
PLoS ONE, 2010 Platelet-derived growth factor receptor beta (PDGFRbeta) is a tyrosine kinase receptor known to affect vascular development. The zebrafish is an excellent model to study specific regulators of vascular development, yet the role of PDGF signaling has not ...
Katie M Wiens +5 more
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Differential prognostic impact of platelet-derived growth factor receptor expression in NSCLC
Scientific Reports, 2019 Preclinical evidence suggests that stromal expression of platelet-derived growth factor receptors (PDGFRs) stimulates tumor development and diminishes intratumoral drug uptake.
Thomas Karsten Kilvaer +9 more
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Cellular Physiology and Biochemistry, 2016 Background/Aims: It is difficult to predict acute thrombotic cardiovascular events in the clinic. Few studies have reported the presence of plasma exosomes containing microRNAs (miRNAs) in cardiovascular events.
Ming Tan +6 more
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Indian Journal of Medical and Paediatric Oncology, 2020 Eosinophilia is a common finding in the pediatric age group. While the majority of mild eosinophilia cases are benign and due to reactive causes, persistent hypereosinophilia is uncommon and requires prompt clinical evaluation because of the potential ...
Abdul Wajid Moothedath +4 more
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Clinical Pharmacology: Advances and Applications, 2017 Alexandra Pender,1 Robin L Jones1,2 1Sarcoma Unit, Department of Medicine, The Royal Marsden NHS Foundation Trust, 2Division of Clinical Studies, The Institute of Cancer Research, London, UK Abstract: The outcome of patients with unresectable or ...
Pender A, Jones RL
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Platelet-Derived Growth Factor-Receptor α Strongly Inhibits Melanoma Growth In Vitro and In Vivo
Neoplasia: An International Journal for Oncology Research, 2009 Cutaneous melanoma is the most aggressive skin cancer; it is highly metastatic and responds poorly to current therapies. The expression of platelet-derived growth factor receptors (PDGF-Rs) is reported to be reduced in metastatic melanoma compared with ...
Debora Faraone +11 more
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