Results 31 to 40 of about 500,127 (414)

AFC1 Compound Attenuated MI/R-Induced Ventricular Remodeling via Inhibiting PDGFR and STAT Pathway

Frontiers in Pharmacology, 2019
Background: Effective interventions to improve the outcome of patients subjected to myocardial ischemia reperfusion (MI/R) are urgent in clinical settings. Tanshinone IIA (TSA) is reported to attenuate myocardial injury and improve ventricular remodeling
Jie Liu, Jie Liu, Xiaohui Zhou, Xiaohui Zhou, Qingshu Meng, Qingshu Meng, Kevin W. Huang, Jing Liu, Jing Liu, Jinjun Tie, Jinjun Tie, Rulin Zhuang, Rulin Zhuang, Guohan Chen, Yuhui Zhang, Lu Wei, Lu Wei, Li Huang, Chun Guang Li, Binghui Wang, Binghui Wang, Huimin Fan, Huimin Fan, Huimin Fan, Huimin Fan, Zhongmin Liu, Zhongmin Liu, Zhongmin Liu, Zhongmin Liu   +28 more
doaj   +1 more source

Platelet-Derived Growth Factor (PDGF)/PDGF Receptors (PDGFR) Axis as Target for Antitumor and Antiangiogenic Therapy

Pharmaceuticals, 2010
Angiogenesis in normal and pathological conditions is a multi-step process governed by positive and negative endogenous regulators. Many growth factors are involved in different steps of angiogenesis, like vascular endothelial growth factors (VEGF ...
Anca Maria Cimpean, Marius Raica
doaj   +1 more source

Activation of tyrosine kinases by mutation of the gatekeeper threonine. [PDF]

, 2008
Protein kinases targeted by small-molecule inhibitors develop resistance through mutation of the gatekeeper threonine residue of the active site. Here we show that the gatekeeper mutation in the cellular forms of c-ABL, c-SRC, platelet-derived growth ...
Azam, Mohammad, Daley, George, Gray, Nathanael, KURIYAN, John, Seeliger, Markus   +4 more
core   +1 more source

A Systemic Receptor Network Triggered by Human cytomegalovirus Entry [PDF]

Advances in Virology Volume 2011 (2011), Article ID 262080, 11 pages, 2010
Virus entry is a multistep process that triggers a variety of cellular pathways interconnecting into a complex network, yet the molecular complexity of this network remains largely unsolved. Here, by employing systems biology approach, we reveal a systemic virus-entry network initiated by human cytomegalovirus (HCMV), a widespread opportunistic ...
arxiv   +1 more source

Phase 1 trial of olaratumab monotherapy and in combination with chemotherapy in pediatric patients with relapsed/refractory solid and central nervous system tumors

Cancer Medicine, 2021
Olaratumab is a monoclonal antibody that specifically binds to platelet‐derived growth factor receptor alpha (PDGFRα) and blocks receptor activation. We conducted a phase 1 trial to evaluate the safety of olaratumab and determine a recommended dose in ...
Leo Mascarenhas, Chitose Ogawa, Theodore W. Laetsch, Brenda J. Weigel, Michael W. Bishop, Julie Krystal, Scott C. Borinstein, Emily K. Slotkin, Jodi A. Muscal, Pooja Hingorani, Donna E. Levy, Gary Mo, Ashwin Shahir, Jennifer Wright, Steven G. DuBois   +14 more
doaj   +1 more source

Prognostic value of CXCL12 expression in 40 low-grade oligodendrogliomas and oligoastrocytomas. [PDF]

, 2006
Both clinical and biological features have been reported as prognostic factors in low-grade gliomas. Among these, histotype, tumor size, enhancement, age and genetic pattern.
Amerigo Boiardi, Andrea Salmaggi, Antonio Silvani, Bianca Pollo, C. Marras, Chiara Calatozzolo, Danilo Croci, Emanuela Maderna, Maurizio Gelati   +8 more
core   +1 more source

Platelet-derived growth factor. III. Identification of a platelet-derived growth factor receptor by affinity labeling.

Journal of Biological Chemistry, 1982
Two homobifunctional cross-linking reagents have been used to cross-link 125I-platelet-derived growth factor (PDGF) to a cell surface component with an approximate Mr = 164,000 that has many characteristics of a specific PDGF receptor. Excess unlabeled PDGF competed for labeling of this component, while high concentrations of fibroblast growth factor ...
K Glenn, D F Bowen-Pope, Russell Ross
openaire   +3 more sources

Involvement of platelet‐derived growth factor ligands and receptors in tumorigenesis [PDF]

Journal of Internal Medicine, 2017
AbstractPlatelet‐derived growth factor (PDGF) isoforms and their receptors have important roles during embryogenesis, particularly in the development of various mesenchymal cell types in different organs. In the adult, PDGF stimulates wound healing and regulates tissue homeostasis.
Carl-Henrik Heldin, Carl-Henrik Heldin, Bengt Westermark, Johan Lennartsson, Johan Lennartsson   +4 more
openaire   +3 more sources

Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta.

New England Journal of Medicine, 2002
BACKGROUND A small proportion of patients with chronic myeloproliferative diseases have constitutive activation of the gene for platelet-derived growth factor receptor beta (PDGFRB), which encodes a receptor tyrosine kinase.
J. Apperley, M. Gardembas, J. Melo, R. Russell‐Jones, B. Bain, E. Baxter, A. Chase, J. Chessells, Marie Colombat, C. Dearden, S. Dimitrijević, F. Mahon, D. Marin, Z. Nikolova, E. Olavarría, S. Silberman, B. Schultheis, N. Cross, J. Goldman   +18 more
semanticscholar   +1 more source

Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta [PDF]

Arthritis Research \& Therapy, 2010, 13 (1), pp.R23. \. \<10.1038/sj.onc.1204808\>, 2015
Transforming growth factor beta (TGF$\beta$) plays a central role in morphogenesis, growth, and cell differentiation. This cytokine is particularly important in cartilage where it regulates cell proliferation and extracellular matrix synthesis. While the action of TGF$\beta$ on chondrocyte metabolism has been extensively catalogued, the modulation of ...
arxiv   +1 more source