Results 31 to 40 of about 126,363 (161)

Artificial Control of Subtype-Specific Platelet-Derived Growth Factor– Receptor Signaling

Journal of Pharmacological Sciences, 2009
Platelet-derived growth factor (PDGF) signaling controls various physiological functions via two receptor subtypes: PDGF receptor (PDGFR) α and PDGFRβ. Nevertheless, our understanding of their roles is limited because of a lack of pharmacological tools ...
Masayuki Isa, Yusaku Ohta, Shigeyuki Namiki, Kenzo Hirose   +3 more
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Imatinib is active in glioblastoma multiforme expressing platelet-derived growth factor receptor [PDF]

Einstein (São Paulo), 2008
Objective: To report on 15 patients with recurrent anaplastic astrocytoma (AA) or glioblastoma multiforme (GBM) previously treated with standard therapies and, then, treated with imatinib.
Fabiana Viola, Jaques Tabacof, Rene Cláudio Gansl, Rober Abramoff, Artur Katz, Carlos Henrique Barrios, Sergio Daniel Simon   +6 more
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Platelet-derived growth factor receptor-β antagonism restores morphine analgesic potency against neuropathic pain. [PDF]

PLoS ONE, 2014
Chronic, intractable pain is a problem of pandemic proportions. Pain caused by nerve injuries (neuropathic pain) is extremely difficult to treat. For centuries, opiates such as morphine have been the first-line treatment for severe chronic pain. However,
Courtney L Donica, Yan Cui, Shanping Shi, Howard B Gutstein   +3 more
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Pazopanib for the treatment of soft-tissue sarcoma

Clinical Pharmacology: Advances and Applications, 2012
Pierre Heudel,1 Philippe Cassier,1 Olfa Derbel,1 Armelle Dufresne,1 Pierre Meeus,2 Philippe Thiesse,3 Dominique Ranchère-Vince,4 Jean Yves Blay,1 Isabelle Ray-Coquard1,51Department of Medical Oncology, 2Department of Surgical Oncology ...
Heudel P, Cassier P, Derbel O, Dufresne A, Meeus P, Thiesse P, Ranchère-Vince D, Blay JY, Ray-Coquard I   +8 more
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Case report: Primary familial brain calcification associated with a rare PDGFRB variant, coexisting with nontraumatic osteonecrosis of the femoral head

Frontiers in Neuroscience
Primary familial brain calcification (PFBC) is a rare genetic neurodegenerative disorder characterized by bilateral calcifications in the brain. PFBC may manifest with a broad spectrum of motor, cognitive, and neuropsychiatric symptoms.
Conghui Cao, Jing Luo, Jing Luo, Xiaoli Wang   +3 more
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6-Methoxy-2-methyl-1-m-tolyl-1H-benzimidazole hemihydrate

Acta Crystallographica Section E, 2011
The title compound, C16H16N2O·0.5H2O, is a substituted 1-phenylbenzimidazole, which belongs to the class of ATP-site inhibitors of the platelet-derived growth-factor receptor.
Xu-Bin Fang, Lei Fang, Xu-Ying Liu
doaj   +1 more source

Medical approach to the treatment of feline injection site sarcoma with masitinib: a case report

Veterinary Medicine: Research and Reports, 2014
Jean-Marie Ledoux,1 Pascal Brun,2 Tom Chapuis,2 Paul Dumas,3 Jean Guillotin41Veterinary Surgery, Lys-Lez-Lannoy, 2AB Science, Paris, 3Laboratoire de Pathologie Vétérinaire du Nord, Annœullin, 4Laboratoire Départemental Public ...
Ledoux JM, Brun P, Chapuis T, Dumas P, Guillotin J   +4 more
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Probing the Effects of the FGFR-Inhibitor Derazantinib on Vascular Development in Zebrafish Embryos

Pharmaceuticals, 2020
Angiogenesis is a fundamental developmental process and a hallmark of cancer progression. Receptor tyrosine kinases (RTK) are targets for cancer therapy which may include their action as anti-angiogenic agents.
Maria P. Kotini, Felix Bachmann, Jochen Spickermann, Paul M. McSheehy, Markus Affolter   +4 more
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Expressão do P16 e do PDGFR-Beta no adenocarcinoma gástrico

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Detectar a expressão imunoistoquímica do p16 e do PDGFR-beta no adenocarcinoma gástrico. MÉTODOS: Foram estudados 36 pacientes submetidos a cirurgia para adenocarcinoma gástrico entre 1998 e 2002 no Hospital da Santa Casa de Porto Alegre.
Rodrigo Pozza Pinto, Fernando Krebs Cirne Lima, Jane M U Kulkzynski, Luis Fernando Moreira   +3 more
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Involvement of Platelet-Derived Growth Factor–BB and Its Receptor-β in Hypoxia-Induced Depression of Excitatory Synaptic Transmission in the Nucleus Tractus Solitarius of Mice

Journal of Pharmacological Sciences, 2010
The role of platelet-derived growth factor (PDGF)-BB / PDGF receptor (PDGFR)-β signal in inhibition of synaptic transmission by hypoxia is unclear. In the nucleus tractus solitarius neurons, hypoxia with N2 or NaCN decreased the amplitude of excitatory ...
Yoshiaki Ohi, Yoko Ishii, Masakiyo Sasahara, Akira Haji   +3 more
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