Results 31 to 40 of about 191,742 (248)

Chronic eosinophilic leukemia with Fip 1-like 1-platelet-derived growth factor receptor alpha mutation: A rare case report

Journal of Applied Hematology, 2015
Chronic eosinophilic leukemia (CEL) is a rare cause of eosinophilia. CEL is known to be associated with BCR-ABL fusion gene or rearrangement of platelet-derived growth factor receptor alpha (PDGFRA), (Platelet-derived growth factor receptor betaPDGFRB or
Khushboo Dewan, Col Tathagata Chatterjee
doaj   +1 more source

Platelet-derived growth factors and their receptors: Structural and functional perspectives [PDF]

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013
The four types of platelet-derived growth factors (PDGFs) and the two types of PDGF receptors (PDGFRs, which belong to class III receptor tyrosine kinases) have important functions in the development of connective tissue cells. Recent structural studies have revealed novel mechanisms of PDGFs in propeptide loading and receptor recognition/activation ...
Xiaolin He, Xiaoyan Chen, Po Han Chen
openaire   +3 more sources

Phase 1 trial of olaratumab monotherapy and in combination with chemotherapy in pediatric patients with relapsed/refractory solid and central nervous system tumors

Cancer Medicine, 2021
Olaratumab is a monoclonal antibody that specifically binds to platelet‐derived growth factor receptor alpha (PDGFRα) and blocks receptor activation. We conducted a phase 1 trial to evaluate the safety of olaratumab and determine a recommended dose in ...
Leo Mascarenhas, Chitose Ogawa, Theodore W. Laetsch, Brenda J. Weigel, Michael W. Bishop, Julie Krystal, Scott C. Borinstein, Emily K. Slotkin, Jodi A. Muscal, Pooja Hingorani, Donna E. Levy, Gary Mo, Ashwin Shahir, Jennifer Wright, Steven G. DuBois   +14 more
doaj   +1 more source

Platelet-derived growth factor receptor-β in Gorham's disease [PDF]

Nature Clinical Practice Oncology, 2006
A 17-year-old male presented with pain in his lower-left chest. He had no significant medical history and was previously in good health. He had a fractured ninth left anterior rib and the tenth, eleventh and twelfth ribs were absent, which was thought to be a congenital anomaly. Several months later, he presented again with back pain, an enlarging mass
Andrew E. Rosenberg, Dan G. Duda, Thomas F. DeLaney, Rakesh K. Jain, David H. Ebb, Henning A. Gaissert, G. Petur Nielsen, Jennifer M. Pearce, Torunn I. Yock, Timothy P. Padera, Jeroen Hagendoorn, Emmanuelle di Tomaso   +11 more
openaire   +3 more sources

Evaluation of serum platelet-derived growth factor receptor-ß and brain-derived neurotrophic factor levels in microvascular angina

Anatolian Journal of Cardiology, 2020
Objective: Microvascular angina (MVA) is a coronary microcirculation disease. Research on microcirculatory dysfunction has revealed several biomarkers involved in the etiopathogenesis of MVA.
Gamze Aslan, Veli Polat, Evin Bozcali, Mustafa Hakan Şahin, Nurcan Çetin, Dilek Ural   +5 more
doaj   +1 more source

Potential mechanisms involved on how systemic IgG antibodies specific to vascular endothelial growth factor (VEGF) and induced by active immunotherapy decrease platelet derived free-VEGF

Platelets, 2022
CIGB-247 is a vascular endothelial growth factor (VEGF)-based active immunotherapy and it is currently under investigation for cancer treatment. This specific active immunotherapy encompasses two vaccine candidates that use a human VEGF variant molecule ...
Javier Sánchez Ramírez, Yanelys Morera Díaz, Mónica Bequet-Romero, Marta Ayala Ávila   +3 more
doaj   +1 more source

Freeze-Dried Platelet-Rich Plasma Induces Osteoblast Proliferation via Platelet-Derived Growth Factor Receptor-Mediated Signal Transduction [PDF]

Asian Spine Journal, 2020
Study Design Controlled laboratory study. Purpose This study aimed to evaluate the in vitro pharmacological activity of growth factors (GFs) in freeze-dried platelet-rich plasma (FD-PRP) after storage for 4 weeks.
Hideyuki Kinoshita, Sumihisa Orita, Kazuhide Inage, Kazuki Fujimoto, Yasuhiro Shiga, Koki Abe, Masahiro Inoue, Masaki Norimoto, Tomotaka Umimura, Takeshi Ishii, Tsukasa Yonemoto, Hiroto Kamoda, Toshinori Tsukanishi, Masahiko Suzuki, Naoya Hirosawa, Tsutomu Akazawa, Seiji Ohtori   +16 more
doaj   +1 more source

Platelet-derived growth factor receptors and phospholipase C activation

Kidney International, 1992
Platelet-derived growth factor (PDGF) has been assigned a broad range of biological roles in contexts ranging from development and oncogenesis to wound healing and atherogenesis [1]. Originally assayed as mitogenic activity released from platelets, it is now appreciated that, in addition to its proliferative actions, PDGF stimulates other processes ...
Thomas O. Daniel, Dana A. Kumjian
openaire   +3 more sources

Platelets promote osteosarcoma cell growth through activation of the platelet-derived growth factor receptor-Akt signaling axis

Cancer Science, 2014
The interactions of tumor cells with platelets contribute to the progression of tumor malignancy, and the expression levels of platelet aggregation‐inducing factors positively correlate with the metastatic potential of osteosarcoma cells.
S. Takagi, Ai Takemoto, Miho Takami, T. Oh‐hara, N. Fujita   +4 more
semanticscholar   +1 more source

Clinical Benefit of Pazopanib in a Patient with Metastatic Chondrosarcoma: A Case Report and Review of the Literature

Frontiers in Oncology, 2018
Chondrosarcoma is a rare malignancy characterized by the production of cartilage matrix, displaying heterogeneous histopathology and clinical behavior.
Onoufrios Tsavaris, Panagiota Economopoulou, Ioannis Kotsantis, Lazaros Reppas, Chrysanthi Avgerinou, Nikolaos Spathas, Maria Prevezanou, Amanda Psyrri   +7 more
doaj   +1 more source