Results 41 to 50 of about 191,742 (248)
Frontiers in Endocrinology, 2022 Receptor tyrosine kinases (RTKs) serve as transmembrane receptors that participate in a broad spectrum of cellular processes including cellular growth, motility, differentiation, proliferation, and metabolism. Hence, elucidating the regulatory mechanisms
Rong Tang +2 more
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Journal of Pharmacological Sciences, 2010 The role of platelet-derived growth factor (PDGF)-BB / PDGF receptor (PDGFR)-β signal in inhibition of synaptic transmission by hypoxia is unclear. In the nucleus tractus solitarius neurons, hypoxia with N2 or NaCN decreased the amplitude of excitatory ...
Yoshiaki Ohi +3 more
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Stage specific requirement of platelet-derived growth factor receptor-α in embryonic development. [PDF]
PLoS ONE, 2017 Platelet-derived growth factor receptor alpha (PDGFRα) is a cell-surface receptor tyrosine kinase for platelet-derived growth factors. Correct timing and level of Pdgfra expression is crucial for embryo development, and deletion of Pdgfra caused ...
Chen Qian +7 more
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Interactions between the receptors for platelet-derived growth factor and epidermal growth factor. [PDF]
The Journal of cell biology, 1983 Preincubation of Swiss 3T3 cells or human fibroblasts with purified platelet-derived growth factor (PDGF) at 4 degrees C or 37 degrees C rapidly inhibits subsequent binding of 125I-epidermal growth factor (125I-EGF). The effect does not result from competition by PDGF for binding to the EGF receptor since (a) very low concentrations of PDGF are ...
D F Bowen-Pope +2 more
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Safety and Efficacy of Sunitinib in Patients with Unresectable Pancreatic Neuroendocrine Tumors
Clinical Medicine Insights: Oncology, 2012 Pancreatic neuroendocrine tumors (PNETs) are becoming increasingly common, with the majority of patients presenting with either lymph node involvement or metastatic disease, thus requiring systemic therapy.
Marcus W. Wiedmann, Joachim Mössner
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International Journal of Experimental Pathology, 2011 SummaryPlatelet‐derived growth factor (PDGF) and its receptors (PDGFRs) are strongly involved in the normal development of several organs, tumour angiogenesis and malignant progression and metastasis. Few studies concerning their expression, distribution and role in normal and pathological human thymus are available in the literature.
Anca Maria Cimpean +5 more
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Platelet-derived growth factor receptor beta is critical for zebrafish intersegmental vessel formation. [PDF]
PLoS ONE, 2010 Platelet-derived growth factor receptor beta (PDGFRbeta) is a tyrosine kinase receptor known to affect vascular development. The zebrafish is an excellent model to study specific regulators of vascular development, yet the role of PDGF signaling has not ...
Katie M Wiens +5 more
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Isolation and characterization of the platelet-derived growth factor beta receptor promoter [PDF]
Developmental Dynamics, 1997 The PDGFbeta r gene has been implicated in many physiological processes including development and wound healing. Aberrant expression of the receptor is seen in many pathological conditions such as atherosclerosis and inflammatory diseases. To study the mechanisms of PDGFbeta r regulation, we identified the regulatory regions of the gene. We have cloned
Eve Shinbrot +2 more
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Hypoxic Ventilatory Response in Platelet-Derived Growth Factor Receptor-β–Knockout Mice
Journal of Pharmacological Sciences, 2009 .: The present study investigated whether the platelet-derived growth factor receptor (PDGFR)-β–mediated mechanisms are involved in the hypoxic ventilatory response through modulating the N-methyl-D-aspartate (NMDA) function.
Saori Tsunekawa +4 more
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The roles of platelet-derived growth factors and their receptors in brain radiation necrosis [PDF]
Radiation Oncology, 2014 Brain radiation necrosis (RN) occurring after radiotherapy is a serious complication. We and others have performed several treatments for RN, using anticoagulants, corticosteroids, surgical resection and bevacizumab. However, the mechanisms underlying RN have not yet been completely elucidated.
Hiroko Kuwabara +8 more
openaire +3 more sources