Results 41 to 50 of about 258,688 (303)
Papillomavirus E5: the smallest oncoprotein with many functions [PDF]
, 2011 Papillomaviruses (PVs) are established agents of human and animal cancers. They infect cutaneous and mucous epithelia. High Risk (HR) Human PVs (HPVs) are consistently associated with cancer of the uterine cervix, but are also involved in the ...
Borzacchiello, G. +6 more
core +4 more sources
Journal of Pharmacological Sciences, 2010 The role of platelet-derived growth factor (PDGF)-BB / PDGF receptor (PDGFR)-β signal in inhibition of synaptic transmission by hypoxia is unclear. In the nucleus tractus solitarius neurons, hypoxia with N2 or NaCN decreased the amplitude of excitatory ...
Yoshiaki Ohi +3 more
doaj +1 more source
Stage specific requirement of platelet-derived growth factor receptor-α in embryonic development. [PDF]
PLoS ONE, 2017 Platelet-derived growth factor receptor alpha (PDGFRα) is a cell-surface receptor tyrosine kinase for platelet-derived growth factors. Correct timing and level of Pdgfra expression is crucial for embryo development, and deletion of Pdgfra caused ...
Chen Qian +7 more
doaj +1 more source
Receptor Tyrosine Kinases Fall into Distinct Classes Based on Their Inferred Signaling Networks [PDF]
, 2013 Although many anticancer drugs that target receptor tyrosine kinases (RTKs) provide clinical benefit, their long-term use is limited by resistance that is often attributed to increased abundance or activation of another RTK that compensates for the ...
Grenier, Jennifer K. +6 more
core +1 more source
Cardiotrophin-1 promotes a high survival rate in rabbits with lethal fulminant hepatitis of viral origin [PDF]
, 2011 Rabbit hemorrhagic disease virus (RHDV) causes lethal fulminant hepatitis closely resembling acute liver failure (ALF) in humans. In this study, we investigated whether cardiotrophin-1 (CT-1), a cytokine with hepatoprotective properties, could attenuate ...
Alvarez, M. (Marcelino) +9 more
core +2 more sources
Safety and Efficacy of Sunitinib in Patients with Unresectable Pancreatic Neuroendocrine Tumors
Clinical Medicine Insights: Oncology, 2012 Pancreatic neuroendocrine tumors (PNETs) are becoming increasingly common, with the majority of patients presenting with either lymph node involvement or metastatic disease, thus requiring systemic therapy.
Marcus W. Wiedmann, Joachim Mössner
doaj +1 more source
Platelet-derived growth factor receptor beta is critical for zebrafish intersegmental vessel formation. [PDF]
PLoS ONE, 2010 Platelet-derived growth factor receptor beta (PDGFRbeta) is a tyrosine kinase receptor known to affect vascular development. The zebrafish is an excellent model to study specific regulators of vascular development, yet the role of PDGF signaling has not ...
Katie M Wiens +5 more
doaj +1 more source
The platelet-derived growth factor receptor alpha promoter-directed expression of cre recombinase in mouse placenta. [PDF]
, 2019 BackgroundNumerous pathologies of pregnancy originate from placental dysfunction. It is essential to understand the functions of key genes in the placenta in order to discern the etiology of placental pathologies.
Lee, Samuel +4 more
core +1 more source
Cellular Physiology and Biochemistry, 2016 Background/Aims: It is difficult to predict acute thrombotic cardiovascular events in the clinic. Few studies have reported the presence of plasma exosomes containing microRNAs (miRNAs) in cardiovascular events.
Ming Tan +6 more
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source