Results 51 to 60 of about 191,742 (248)

Peptide-Based Targeting of the Platelet-Derived Growth Factor Receptor Beta [PDF]

Molecular Imaging and Biology, 2012
The aim of this work is to identify new ligands targeting the platelet-derived growth factor receptor beta (PDGFRβ).Biopanning was carried out with a 12-amino-acid phage display library against the recombinant extracellular domain of PDGFRβ. The identified peptide PDGFR-P1 was chemically synthesized and labeled with (125)I or (131)I.
Jürgen Debus, Annabell Marr, Vasileios Askoxylakis, Walter Mier, Peter E. Huber, Annette Markert, Uwe Haberkorn, Annette Altmann   +7 more
openaire   +3 more sources

Induction of platelet-derived growth factor alpha- and beta-receptor mRNA and protein by platelet-derived growth factor BB. [PDF]

Journal of Biological Chemistry, 1991
We describe that stimulation of human fibroblasts with platelet-derived growth factor BB (PDGF-BB) induces a transient up-regulation of the PDGF alpha- and beta-receptor transcript and protein levels. The effect of PDGF-BB on the receptor transcript levels was more pronounced than those seen when other cytokines were used.
Lena Claesson-Welsh, P Leveen, C H Heldin, Bengt Westermark, Anders Eriksson, Monica Nistér   +5 more
openaire   +2 more sources

Biosynthesis and intracellular transport of the receptor for platelet-derived growth factor. [PDF]

Proceedings of the National Academy of Sciences, 1987
The biosynthesis of the receptor for platelet-derived growth factor (PDGF) was examined in metabolically labeled human foreskin fibroblasts. The receptor was synthesized as a 145-kDa precursor, which, when incubated with endo-beta-N-acetylglucosaminidase H (endo H), underwent a 15-kDa decrease in molecular mass. This indicates that the size of the core
Carl-Henrik Heldin, Lena Claesson-Welsh, Lars Rönnstrand   +2 more
openaire   +3 more sources

Olaratumab: a platelet-derived growth factor receptor-α-blocking antibody for the treatment of soft tissue sarcoma

Clinical Pharmacology: Advances and Applications, 2017
Alexandra Pender,1 Robin L Jones1,2 1Sarcoma Unit, Department of Medicine, The Royal Marsden NHS Foundation Trust, 2Division of Clinical Studies, The Institute of Cancer Research, London, UK Abstract: The outcome of patients with unresectable or ...
Pender A, Jones RL
doaj  

Differential prognostic impact of platelet-derived growth factor receptor expression in NSCLC

Scientific Reports, 2019
Preclinical evidence suggests that stromal expression of platelet-derived growth factor receptors (PDGFRs) stimulates tumor development and diminishes intratumoral drug uptake.
Thomas Karsten Kilvaer, Mehrdad Rakaee, Turid Hellevik, Jørg Vik, Luigi De Petris, Tom Donnem, Carina Strell, Arne Ostman, Lill-Tove Rasmussen Busund, Inigo Martinez-Zubiaurre   +9 more
doaj   +1 more source

A report of an unusual case of pediatric eosinophilia associated with platelet-derived growth factor receptor-beta rearrangement

Indian Journal of Medical and Paediatric Oncology, 2020
Eosinophilia is a common finding in the pediatric age group. While the majority of mild eosinophilia cases are benign and due to reactive causes, persistent hypereosinophilia is uncommon and requires prompt clinical evaluation because of the potential ...
Abdul Wajid Moothedath, Debasish Sahoo, Rachna Seth, Jagdish Prasad Meena, Aditya Kumar Gupta   +4 more
doaj   +1 more source

Platelet-Derived Growth Factor Receptor-β Expression in Human Peritoneum [PDF]

Nephron Clinical Practice, 2014
<b><i>Introduction:</i></b> Simple peritoneal fibrosis and encapsulating peritoneal sclerosis (EPS) are important lesions in the peritoneum of patients on peritoneal dialysis (PD). We have previously described a population of podoplanin-positive myofibroblasts in peritoneal biopsies from patients with EPS.
Harald Seeger, Niko Braun, Joerg Latus, M. Dominik Alscher, Peter Fritz, Ilka Edenhofer, Dagmar Biegger, Maja Lindenmeier, Rudolf P. Wüthrich, Stephan Segerer   +9 more
openaire   +3 more sources

Postnatal Tendon Growth and Remodeling Requires Platelet-Derived Growth Factor Receptor Signaling [PDF]

American Journal of Physiology-Cell Physiology, 2017
ABSTRACTPlatelet-derived growth factor receptor (PDGFR) signaling plays an important role in the fundamental biological activities of many cells that compose musculoskeletal tissues. However, little is known about the role of PDGFR signaling during tendon growth and remodeling in adult animals.
Kristoffer B. Sugg, Nathaniel P Disser, Andrew M. Rizzi, Dylan C. Sarver, Christopher L. Mendias, Christopher L. Mendias, James F. Markworth, Susan V. Brooks, Jeffrey R. Talarek   +8 more
openaire   +4 more sources

In Situ Detection of Phosphorylated Platelet-derived Growth Factor Receptor β Using a Generalized Proximity Ligation Method*

Molecular & Cellular Proteomics, 2007
Improved methods are needed for in situ characterization of post-translational modifications in cell lines and tissues. For example, it is desirable to monitor the phosphorylation status of individual receptor tyrosine kinases in samples from human ...
M. Jarvius, Janna Paulsson, I. Weibrecht, Karl‐Johan Leuchowius, A. Andersson, Carolina Wählby, M. Gullberg, J. Botling, T. Sjöblom, B. Markova, A. Ostman, U. Landegren, O. Söderberg   +12 more
semanticscholar   +1 more source

Imatinib is active in glioblastoma multiforme expressing platelet-derived growth factor receptor [PDF]

Einstein (São Paulo), 2008
Objective: To report on 15 patients with recurrent anaplastic astrocytoma (AA) or glioblastoma multiforme (GBM) previously treated with standard therapies and, then, treated with imatinib.
Fabiana Viola, Jaques Tabacof, Rene Cláudio Gansl, Rober Abramoff, Artur Katz, Carlos Henrique Barrios, Sergio Daniel Simon   +6 more
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