Results 61 to 70 of about 191,742 (248)

Platelet-Derived Growth Factor-Receptor α Strongly Inhibits Melanoma Growth In Vitro and In Vivo

Neoplasia: An International Journal for Oncology Research, 2009
Cutaneous melanoma is the most aggressive skin cancer; it is highly metastatic and responds poorly to current therapies. The expression of platelet-derived growth factor receptors (PDGF-Rs) is reported to be reduced in metastatic melanoma compared with ...
Debora Faraone, Maria Simona Aguzzi, Gabriele Toietta, Angelo M. Facchiano, Francesco Facchiano, Alessandra Magenta, Fabio Martelli, Silvia Truffa, Eleonora Cesareo, Domenico Ribatti, Maurizio C. Capogrossi, Antonio Facchiano   +11 more
doaj   +1 more source

Platelet-derived growth factor receptor-β antagonism restores morphine analgesic potency against neuropathic pain. [PDF]

PLoS ONE, 2014
Chronic, intractable pain is a problem of pandemic proportions. Pain caused by nerve injuries (neuropathic pain) is extremely difficult to treat. For centuries, opiates such as morphine have been the first-line treatment for severe chronic pain. However,
Courtney L Donica, Yan Cui, Shanping Shi, Howard B Gutstein   +3 more
doaj   +1 more source

Convergence of Angiotensin II and Platelet-derived Growth Factor Receptor Signaling Cascades in Vascular Smooth Muscle Cells (*)

Journal of Biological Chemistry, 1995
Signaling cascades elicited by angiotensin II resemble those characteristic of growth factor stimulation. In this report, we demonstrate that angiotensin II converges with platelet-derived growth factor (PDGF) β-receptor signaling cascades, independent ...
D. Linseman, C. Benjamin, David Ackley Jones   +2 more
semanticscholar   +1 more source

Platelet-derived growth factor receptors in the kidney—Upregulated expression in inflammation

Kidney International, 1989
Major features of a long-standing inflammation in the kidney are vascular proliferation, glomerulosclerosis, interstitial fibrosis and tubular atrophy, leading to a gradual deterioration of the renal function. In this study we have investigated the expression of B-type receptors for platelet-derived growth factor (PDGF) in frozen sections from normal ...
Gunnar Tufveson, Kristoffer Rubin, Carl H. Heldin, Lars Klareskog, Louis Terracio, Lars Rönnstrand, Erik Larsson, Jan Wahlberg, Bengt Fellström   +8 more
openaire   +3 more sources

Platelet-derived Growth Factor Receptor β and Vascular Endothelial Growth Factor Receptor 2 Bind to the β3Integrin through Its Extracellular Domain*

Journal of Biological Chemistry, 2000
Integrin-mediated cell attachment and growth factor stimulation often act synergistically on cell proliferation, differentiation, migration, and survival.
E. Borges, Y. Jan, E. Ruoslahti
semanticscholar   +1 more source

Outcome of Patients with Platelet-Derived Growth Factor Receptor Alpha–Mutated Gastrointestinal Stromal Tumors in the Tyrosine Kinase Inhibitor Era

Clinical Cancer Research, 2012
Purpose: Platelet-derived growth factor receptor-alpha (PDGFRA) mutations are found in approximately 5% to 7% of advanced gastrointestinal stromal tumors (GIST). We sought to extensively assess the activity of imatinib in this subgroup.
P. Cassier, E. Fumagalli, P. Rutkowski, P. Schöffski, M. V. Van Glabbeke, M. Debiec-Rychter, J. Emile, F. Duffaud, J. Martín-Broto, B. Landi, A. Adenis, F. Bertucci, E. Bompas, O. Bouché, S. Leyvraz, I. Judson, J. Verweij, P. Casali, J. Blay, P. Hohenberger   +19 more
semanticscholar   +1 more source

Cbl-mediated Negative Regulation of Platelet-derived Growth Factor Receptor-dependent Cell Proliferation

Journal of Biological Chemistry, 1999
The Cbl proto-oncogene product has emerged as a novel negative regulator of receptor and non-receptor tyrosine kinases. Our previous observations that Cbl overexpression in NIH3T3 cells enhanced the ubiquitination and degradation of the platelet-derived ...
S. Miyake, Karen P. Mullane-Robinson, N. L. Lill, P. Douillard, H. Band   +4 more
semanticscholar   +1 more source

Pazopanib for the treatment of soft-tissue sarcoma

Clinical Pharmacology: Advances and Applications, 2012
Pierre Heudel,1 Philippe Cassier,1 Olfa Derbel,1 Armelle Dufresne,1 Pierre Meeus,2 Philippe Thiesse,3 Dominique Ranchère-Vince,4 Jean Yves Blay,1 Isabelle Ray-Coquard1,51Department of Medical Oncology, 2Department of Surgical Oncology ...
Heudel P, Cassier P, Derbel O, Dufresne A, Meeus P, Thiesse P, Ranchère-Vince D, Blay JY, Ray-Coquard I   +8 more
doaj  

Case report: Primary familial brain calcification associated with a rare PDGFRB variant, coexisting with nontraumatic osteonecrosis of the femoral head

Frontiers in Neuroscience
Primary familial brain calcification (PFBC) is a rare genetic neurodegenerative disorder characterized by bilateral calcifications in the brain. PFBC may manifest with a broad spectrum of motor, cognitive, and neuropsychiatric symptoms.
Conghui Cao, Jing Luo, Jing Luo, Xiaoli Wang   +3 more
doaj   +1 more source

6-Methoxy-2-methyl-1-m-tolyl-1H-benzimidazole hemihydrate

Acta Crystallographica Section E, 2011
The title compound, C16H16N2O·0.5H2O, is a substituted 1-phenylbenzimidazole, which belongs to the class of ATP-site inhibitors of the platelet-derived growth-factor receptor.
Xu-Bin Fang, Lei Fang, Xu-Ying Liu
doaj   +1 more source