Results 61 to 70 of about 334,171 (270)

Individual participant data from digital sources informed and improved precision in the evaluation of predictive biomarkers in Bayesian network meta-analysis [PDF]

arXiv, 2023
Objective: We aimed to develop a meta-analytic model for evaluation of predictive biomarkers and targeted therapies, utilising data from digital sources when individual participant data (IPD) from randomised controlled trials (RCTs) are unavailable. Methods: A Bayesian network meta-regression model, combining aggregate data (AD) from RCTs and IPD ...
arxiv  

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Platelet-Derived Growth Factor-Receptor α Strongly Inhibits Melanoma Growth In Vitro and In Vivo

Neoplasia: An International Journal for Oncology Research, 2009
Cutaneous melanoma is the most aggressive skin cancer; it is highly metastatic and responds poorly to current therapies. The expression of platelet-derived growth factor receptors (PDGF-Rs) is reported to be reduced in metastatic melanoma compared with ...
Debora Faraone, Maria Simona Aguzzi, Gabriele Toietta, Angelo M. Facchiano, Francesco Facchiano, Alessandra Magenta, Fabio Martelli, Silvia Truffa, Eleonora Cesareo, Domenico Ribatti, Maurizio C. Capogrossi, Antonio Facchiano   +11 more
doaj   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Murine Models and Human Cell Line Models to Study Altered Dynamics of Ovarian Follicles in Polycystic Ovary Syndrome

Advanced Biology, EarlyView.
The manuscript examines preclinical murine and human models to study polycystic ovary syndrome (PCOS), delving into the cellular and molecular mechanisms underlying altered ovarian follicular dynamics. It explores the cellular interactions involved in normal and PCOS ovaries and outlines the current and novel strategies in the search for preclinical ...
Arturo Bevilacqua, Cristiano Giuliani, Giovanna Di Emidio, Samuel H Myers, Vittorio Unfer, Carla Tatone   +5 more
wiley   +1 more source

Artificial Control of Subtype-Specific Platelet-Derived Growth Factor– Receptor Signaling

Journal of Pharmacological Sciences, 2009
Platelet-derived growth factor (PDGF) signaling controls various physiological functions via two receptor subtypes: PDGF receptor (PDGFR) α and PDGFRβ. Nevertheless, our understanding of their roles is limited because of a lack of pharmacological tools ...
Masayuki Isa, Yusaku Ohta, Shigeyuki Namiki, Kenzo Hirose   +3 more
doaj  

Novel Biologically Active Glass Fiber Functionalized Using Magnesium Phosphate Cement Promotes Bone and Vascular Regeneration

Advanced Biology, EarlyView.
In this study, a new type of bioactive glass fiber ‐based composite magnesium phosphate bone cement is prepared and verified that its mechanical strength and biological properties. In addition, the cement may have played a biologically active role in the Notch and HIF signaling pathways.
Yuzheng Lu, Yanbo Shan, Yingjie Xiong, Jianting Ye, Yanbin Wu, Jipeng Song, Yao Zhang, Wancheng Lin, Haoye Meng, Wenjing Xu, Jiang Peng, Qiang Lu, Lixiang Ding   +12 more
wiley   +1 more source

Ligand-induced Coupling versus Receptor Pre-association: Cellular automaton simulations of FGF-2 binding [PDF]

J. Theor. Biol. 227(2) 239-251 (2004), 2003
The binding of basic fibroblast growth factor (FGF-2) to its cell surface receptor (CSR) and subsequent signal transduction is known to be enhanced by Heparan Sulfate Proteoglycans (HSPGs). HSPGs bind FGF-2 with low affinity and likely impact CSR-mediated signaling via stabilization of FGF-2-CSR complexes via association with both the ligand and the ...
arxiv  

Material Challenges and Alloy Selection for Particle/s‐CO2 Heat Exchangers in Concentrated Solar Power Systems

Advanced Engineering Materials, EarlyView.
Combining supercritical CO2 (s‐CO2) cycles with particle‐based heat transfer media holds great potential in concentrated solar power plants but poses enormous material challenges. The particle/s‐CO2 heat exchanger must withstand extreme conditions, including high temperatures, pressures, CO2 corrosion, and erosion.
Mathias Christian Galetz, Emma Marie Hamilton White, Michael Kerbstadt, Clara Schlereth, Xabier Montero, Daniel Benitez   +5 more
wiley   +1 more source

Platelet-derived growth factor receptor-β antagonism restores morphine analgesic potency against neuropathic pain. [PDF]

PLoS ONE, 2014
Chronic, intractable pain is a problem of pandemic proportions. Pain caused by nerve injuries (neuropathic pain) is extremely difficult to treat. For centuries, opiates such as morphine have been the first-line treatment for severe chronic pain. However,
Courtney L Donica, Yan Cui, Shanping Shi, Howard B Gutstein   +3 more
doaj   +1 more source