Results 71 to 80 of about 191,742 (248)

Probing the Effects of the FGFR-Inhibitor Derazantinib on Vascular Development in Zebrafish Embryos

Pharmaceuticals, 2020
Angiogenesis is a fundamental developmental process and a hallmark of cancer progression. Receptor tyrosine kinases (RTK) are targets for cancer therapy which may include their action as anti-angiogenic agents.
Maria P. Kotini, Felix Bachmann, Jochen Spickermann, Paul M. McSheehy, Markus Affolter   +4 more
doaj   +1 more source

Medical approach to the treatment of feline injection site sarcoma with masitinib: a case report

Veterinary Medicine: Research and Reports, 2014
Jean-Marie Ledoux,1 Pascal Brun,2 Tom Chapuis,2 Paul Dumas,3 Jean Guillotin41Veterinary Surgery, Lys-Lez-Lannoy, 2AB Science, Paris, 3Laboratoire de Pathologie Vétérinaire du Nord, Annœullin, 4Laboratoire Départemental Public ...
Ledoux JM, Brun P, Chapuis T, Dumas P, Guillotin J   +4 more
doaj  

Kinetic Analysis of Platelet-derived Growth Factor Receptor/Phosphoinositide 3-Kinase/Akt Signaling in Fibroblasts*

Journal of Biological Chemistry, 2003
Isoforms of the serine-threonine kinase Akt coordinate multiple cell survival pathways in response to stimuli such as platelet-derived growth factor (PDGF).
Chang Shin Park, I. Schneider, J. Haugh
semanticscholar   +1 more source

A Case Report of Advanced Lung Adenocarcinoma Harboring KRAS Mutation 
Treated with Anlotinib

Chinese Journal of Lung Cancer, 2018
In recent years, the number of advanced non-small cell lung cancer (NSCLC) patients has gradually increased, and the treatment methods have also been significantly increased.
Yudong SU, Zhaoting MENG, Xiaoyan XU, XinYue WANG, Ran ZUO, Yunxia HOU, Kai LI, Peng CHEN   +7 more
doaj   +1 more source

Imatinib Inhibits GH Secretion From Somatotropinomas

Frontiers in Endocrinology, 2018
Background: Imatinib, a tyrosine kinase inhibitor, causes growth failure in children with chronic myeloid leukemia probably by targeting the growth hormone (GH)/insulin like growth factor-1 (IGF-1) axis.
Prakamya Gupta, Ashutosh Rai, Kanchan Kumar Mukherjee, Naresh Sachdeva, Bishan Das Radotra, Raj Pal Singh Punia, Rakesh Kumar Vashista, Debasish Hota, Anand Srinivasan, Sivashanmugam Dhandapani, Sunil Kumar Gupta, Anil Bhansali, Pinaki Dutta   +12 more
doaj   +1 more source

Expressão do P16 e do PDGFR-Beta no adenocarcinoma gástrico

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Detectar a expressão imunoistoquímica do p16 e do PDGFR-beta no adenocarcinoma gástrico. MÉTODOS: Foram estudados 36 pacientes submetidos a cirurgia para adenocarcinoma gástrico entre 1998 e 2002 no Hospital da Santa Casa de Porto Alegre.
Rodrigo Pozza Pinto, Fernando Krebs Cirne Lima, Jane M U Kulkzynski, Luis Fernando Moreira   +3 more
doaj   +1 more source

Different PDGF Receptor Dimers Drive Distinct Migration Modes of the Mouse Skin Fibroblast

Cellular Physiology and Biochemistry, 2018
Background/Aims: The migration of mesenchymal cells is a fundamental cellular process that has been implicated in many pathophysiological conditions and is induced by chemoattractants such as platelet-derived growth factors (PDGFs).
Kohta Yamada, Takeru Hamashima, Yoko Ishii, Seiji  Yamamoto, Noriko Okuno, Naofumi Yoshida, Moe Yamada, Ting Ting Huang, Norifumi Shioda, Kei Tomihara, Toshihiko Fujimori, Hisashi Mori, Kohji Fukunaga, Makoto Noguchi, Masakiyo Sasahara   +14 more
doaj   +1 more source

Imatinib mesylate treatment for platelet-derived growth factor receptor alfa-positive choroid plexus carcinoma

Clinics and Practice, 2012
We herein report a female child with choroid plexus carcinoma treated with standard dose of imatinib at disease recurrence. This patient failed initial twice-surgical resections, central nervous system (CNS) irradiation, and adjuvant chemotherapies and ...
Chihiro Kawakami, Akiko Inoue, Kimitaka Takitani, Motomu Tsuji, Kimiko Wakai, Hiroshi Tamai   +5 more
doaj   +1 more source

Analysis of platelet-derived growth factor receptor alpha expression in adult mouse testis

Journal of Animal Reproduction and Biotechnology
Background: Platelet-derived growth factor receptor alpha (PDGFRα) is essential for various biological processes, including fetal Leydig cell differentiation.
Min Seok Woo, Eun-Jin Kim, Dong Kun Lee, Chung Eun Lee, Eun-A Ko, Dawon Kang   +5 more
doaj   +1 more source

Phylogenetic analysis of platelet-derived growth factor by radio-receptor assay. [PDF]

, 1982
J P Singh, Margery A. Chaikin, Charles D. Stiles   +2 more
openalex   +1 more source