Results 51 to 60 of about 623,352 (269)

Platelet Size in Relation to Platelet Age

Experimental Biology and Medicine, 1964
SummaryThe frequency distribution of platelet sizes in platelet populations of various ages was investigated using a Coulter Electronic Particle Counter, model B, and a particle size distribution plotter. Platelets were obtained from male Sprague-Dawley rats, young platelets from rats recovering from thrombocytopenia induced with platelet-specific ...
T P, MCDONALD, T T, ODELL, D G, GOSSLEE
openaire   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Relevance and limitations of clinical follow-up in a pharmacokinetic study on direct oral anticoagulants

Frontiers in Pharmacology
IntroductionDirect oral anticoagulants (DOACs), including apixaban and rivaroxaban, are widely prescribed for the prevention of cardioembolic stroke and the treatment of venous thromboembolism.
Jean Terrier, Jean Terrier, Jean Terrier, Pauline Gosselin, Pauline Gosselin, Christophe Combescure, Pierre Fontana, Pierre Fontana, Youssef Daali, Youssef Daali, Jean-Luc Reny, Jean-Luc Reny, Chantal Alves, Frederic Gaspar, Monia Guidi, Lenoir Camille, Victoria Rollason   +16 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

PB2620: NIGHTTIME SYMPTOMS ARE ASSOCIATED WITH FATIGUE AMONG CHILDREN AND ADOLESCENTS WITH CHRONIC ITP: DATA FROM THE ITP NATURAL HISTORY STUDY REGISTRY

HemaSphere, 2023
Jennifer Diraimo, Caroline Kruse, Alexandra Kruse, Kevin Doyoon Won, Rachael F. Grace   +4 more
doaj   +1 more source

Non-canonical non-genomic morphogen signaling in anucleate platelets: a critical determinant of prothrombotic function in circulation

Cell Communication and Signaling
Circulating platelets derived from bone marrow megakaryocytes play a central role in thrombosis and hemostasis. Despite being anucleate, platelets express several proteins known to have nuclear niche.
Paresh P. Kulkarni, Mohammad Ekhlak, Debabrata Dash   +2 more
doaj   +1 more source

Autologous Platelet-Rich Plasma Preparations

Orthopaedic Journal of Sports Medicine, 2015
Background Autologous platelet-rich plasma (PRP) has been widely used for the treatment of sports injuries. It has been associated with improved healing and regeneration of soft tissues in elite athletes. Athletes are commonly receiving nonsteroidal anti-
Gert Schippinger MD, Florian Prüller MD, Manuela Divjak, Elisabeth Mahla MD, Florian Fankhauser MD, Steve Rackemann MD, Reinhard Bernd Raggam MD   +6 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

PB2619: THE IMPACT OF ITP-DIRECTED TREATMENT ON FATIGUE AMONG CHILDREN AND ADOLESCENTS WITH CHRONIC ITP: DATA FROM THE ITP NATURAL HISTORY STUDY REGISTRY

HemaSphere, 2023
Jennifer Diraimo, Caroline Kruse, Alexandra Kruse, Kevin Doyoon Won, Rachael F. Grace   +4 more
doaj   +1 more source

IV Thrombolysis Facilitates Interventional Reperfusion in Non‐Cardioembolic but Not Cardioembolic Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intravenous thrombolysis (IVT) before thrombectomy for ischemic stroke may alter clot structure and procedural performance. We investigated how IVT relates to thrombectomy metrics across stroke etiologies. Methods We performed a time‐to‐event analysis of consecutive patients with anterior circulation large vessel occlusion (acLVO ...
Annahita Sedghi, Daniel P. O. Kaiser, Martin Arndt, Norma J. Diel, Erik Simon, Witold H. Polanski, Volker Puetz, Hagen B. Huttner, Timo Siepmann   +8 more
wiley   +1 more source