Results 1 to 10 of about 358,733 (338)
The Platelet-Activating Factor Receptor’s Association with the Outcome of Ovarian Cancer Patients and Its Experimental Inhibition by Rupatadine [PDF]
Cells, 2021 The platelet-activating factor receptor (PAFR) and its ligand (PAF) are important inflammatory mediators that are overexpressed in ovarian cancer. The receptor is an important player in ovarian cancer development.
Eileen Deuster +14 more
doaj +2 more sources
Hearts, 2021 The purpose of this literature review is to gain an overview of the role of platelet-activating factor (PAF) within each of the body systems and how it contributes to normal and pathophysiological states.
Nilank Shah, Karan Kumar, Nikeith Shah
doaj +1 more source
UVB-Induced Microvesicle Particle Release and Its Effects on the Cutaneous Microenvironment
Frontiers in Immunology, 2022 Ultraviolet B radiation (UVB) has profound effects on human skin that results in a broad spectrum of immunological local and systemic responses and is the major cause of skin carcinogenesis.
Timothy C. Frommeyer +10 more
doaj +1 more source
Cardiogenetics, 2022 Hypertension and atherosclerosis are debilitating diseases that affect millions each year. Long-term consequences include but are not limited to stroke, myocardial infarction, and kidney failure.
Nilank Shah +7 more
doaj +1 more source
Molecular Docking, Drug likeness Studies and ADMET prediction of Flavonoids as Platelet-Activating Factor (PAF) Receptor Binding [PDF]
Chemical Review and Letters, 2021 Studies and scientific research indicate that the platelet-activating factor (PAF) is a major pro-inflammatory mediator in the initiation and development of cancer.
Mohammed BOUACHRINE +6 more
doaj +1 more source
Mechanobiology of shear-induced platelet aggregation leading to occlusive arterial thrombosis: a multiscale in silico analysis [PDF]
, 2021 Occlusive thrombosis in arteries causes heart attacks and strokes. The rapid growth of thrombus at elevated shear rates (~10,000 1/s) relies on shear-induced platelet aggregation (SIPA) thought to come about from the entanglement of von Willebrand factor (VWF) molecules.
arxiv +1 more source
Factor V activity of platelets: evidence for an activated factor V molecule and for a platelet activator [PDF]
Blood, 1977 Abstract This study was prompted by the observation that fresh platelet suspensions--prepared by gel filtration or albumin density gradient centrifugation--possessed only minimal factor V activity, whereas frozen-and-thawed platelet suspensions possessed striking factor V activity.
Samuel I. Rapaport +5 more
openaire +4 more sources
Advanced Biology, Volume 6, Issue 12, December 2022., 2022 Fabrication of a lithography‐less Cayley‐tree pattern to generate a blood‐brain barrier‐on‐a‐chip. The shape of the microchannels in the Cayley‐tree pattern is semi‐elliptical with smooth variation in the height of the microchannels from the parent branch to daughter branches.
Ami Mehta +9 more
wiley +1 more source
Clinical and Applied Thrombosis/Hemostasis, 2021 The precise mechanisms of pathology in severe COVID-19 remains elusive. Current evidence suggests that inflammatory mediators are responsible for the manifestation of clinical symptoms that precedes a fatal response to infection. This review examines the
Mark Klein MD +2 more
doaj +1 more source