Results 1 to 10 of about 1,292,372 (416)

Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat [PDF]

Journal of Occupational Medicine and Toxicology, 2008
Background Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
Groneberg David A, Staats Petra, Schmidt Rene, Wagner Ulrich   +3 more
doaj   +5 more sources

Platelet-Activating Factor Induces Th17 Cell Differentiation [PDF]

Mediators of Inflammation, 2011
Th17 cells have been implicated in a number of inflammatory and autoimmune diseases. The phospholipid mediator platelet-activating factor (PAF) is found in increased concentrations in inflammatory lesions and has been shown to induce IL-6 production.
Anne-Marie Drolet, Maryse Thivierge, Sylvie Turcotte, Dominique Hanna, Bruno Maynard, Jana Stankovà, Marek Rola-Pleszczynski   +6 more
doaj   +4 more sources

Macrophage Derived Platelet Activating Factor Implicated in the Resolution Phase of Gouty Inflammation [PDF]

International Journal of Inflammation, 2014
Human blood derived in vitro differentiated monocytes or macrophages are a population of cells which have been investigated over the years to determine the role these cells play in the resolution phase of gout.
Darshna Yagnik
doaj   +6 more sources

The Platelet-Activating Factor Receptor’s Association with the Outcome of Ovarian Cancer Patients and Its Experimental Inhibition by Rupatadine [PDF]

Cells, 2021
The platelet-activating factor receptor (PAFR) and its ligand (PAF) are important inflammatory mediators that are overexpressed in ovarian cancer. The receptor is an important player in ovarian cancer development.
Eileen Deuster, Ivi Hysenaj, Maja Kahaly, Elisa Schmoeckel, Doris Mayr, Susanne Beyer, Thomas Kolben, Anna Hester, Fabian Kraus, Anca Chelariu-Raicu, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch, Bastian Czogalla   +14 more
doaj   +2 more sources

To hydrolyze or not to hydrolyze: the dilemma of platelet-activating factor acetylhydrolase

Journal of Lipid Research, 2014
Mounting ambiguity persists around the functional role of the plasma form of platelet-activating factor acetylhydrolase (PAF-AH). Because PAF-AH hydrolyzes PAF and related oxidized phospholipids, it is widely accepted as an anti-inflammatory enzyme.
Gopal Kedihitlu Marathe, Chaitanya Pandit, Chikkamenahalli Lakshminarayana Lakshmikanth, Vyala Hanumanthareddy Chaithra, Shancy Petsel Jacob, Cletus Joseph Michael D'Souza   +5 more
doaj   +2 more sources

Impact of targeting the platelet-activating factor and its receptor in cancer treatment [PDF]

Military Medical Research
The lipid mediator platelet-activating factor (PAF) and its receptor (PAFR) signaling play critical roles in a wide range of physiological and pathophysiological conditions, including cancer growth and metastasis.
Kimya Qaderi, Arvin Shahmoradi, Anita Thyagarajan, Ravi P. Sahu   +3 more
doaj   +2 more sources

Ginkgolide B inhibits the neurotoxicity of prions or amyloid-β_1-42 [PDF]

Journal of Neuroinflammation, 2004
Background Neuronal loss in Alzheimer's or prion diseases is preceded by the accumulation of fibrillar aggregates of toxic proteins (amyloid-β1-42 or the prion protein).
Williams Alun, Salmona Mario, Bate Clive
doaj   +3 more sources

Platelet activating factor in allergies

International Journal of Immunopathology and Pharmacology, 2015
The platelet-activating factor (PAF) produced and released by mast cells, basophils, neutrophils, eosinophils, fibroblasts, platelets, endothelial cells, and even cardiac muscle cells plays an important role in inflammatory and thrombotic diseases. PAF has been shown to be an important mediator in anaphylaxis. Serum level of the factor correlates with
Zbigniew Bartuzi, Krzysztof Pałgan
openaire   +4 more sources

Platelet-activating factor acetyl hydrolase IB2 dysregulated cell proliferation in ovarian cancer [PDF]

Cancer Cell International, 2021
Background Ovarian cancer is the leading cause of death from gynaecologic illnessed worldwide. Platelet-activating factor acetyl hydrolase IB2 (PAF-AH IB2) is an intracellular serine esterase that hydrolyzes platelet-activating factor, a G-protein-like ...
YingYing He, Zhicheng He, Xiaoyu Zhang, Shubai Liu   +3 more
doaj   +2 more sources

An immune-adrenergic pathway induces lethal levels of platelet-activating factor in mice. [PDF]

Commun Biol
Acute immune responses with excess production of cytokines, lipid/chemical mediators, or coagulation factors, often result in lethal damage. In addition, the innate immune system utilizes multiple types of receptors that recognize neurotransmitters as ...
Tanaka S, Kawakita M, Yasui H, Sudo K, Itoh F, Sasaki M, Shibata N, Hara H, Iwakura Y, Hashidate-Yoshida T, Shindou H, Shimizu T, Oyama T, Matsunaga H, Takahara K.   +14 more
europepmc   +3 more sources