Results 1 to 10 of about 191,518 (302)

Interplay Between EGFR and the Platelet-Activating Factor/PAF Receptor Signaling Axis Mediates Aggressive Behavior of Cervical Cancer

Frontiers in Oncology, 2020
Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase widely expressed in cervical tumors, being correlated with adverse clinical outcomes. EGFR may be activated by a diversity of mechanisms, including transactivation by G-protein coupled
Juliana L. Souza, Karina Martins-Cardoso, Isabella S. Guimarães, Andréia C. de Melo, Angela H. Lopes, Robson Q. Monteiro, Vitor H. Almeida   +6 more
doaj   +1 more source

Potentiation of thrombus instability: a contributory mechanism to the effectiveness of antithrombotic medications [PDF]

, 2018
© The Author(s) 2018The stability of an arterial thrombus, determined by its structure and ability to resist endogenous fibrinolysis, is a major determinant of the extent of infarction that results from coronary or cerebrovascular thrombosis.
A Gast, AD Michelson, B Labarthe, B Shen, C Patrono, CT Ammollo, D Capodanno, D Gailani, DA Gorog, Diana A. Gorog, DM Coenen, E Álvarez, ER Bates, F Kabirian, F Müller, F Semeraro, G Stephens, H Brogren, HE Speich, HE Speich, HJ Weiss, HJ Weiss, HR Baumgartner, J Zilberman-Rudenko, JD McFadyen, JI Weitz, JM Cosemans, JP Collet, JP Collet, K Hosokawa, K Nagatsuka, KS Sakariassen, L Valerio, LF Brass, M Cattaneo, M Farag, M Humbert, M Larsson, M Li, M Ungerer, MA Bailey, MI Furman, MJ Price, ML Montfoort von, MS Sabatine, P Andre, P Seizer, PA Borne von dem, PP Wadowski, R Hellmuth, R Nergiz-Unal, RA Ajjan, S Goto, S Goto, SA Shaya, SB Larsen, SJ Marciniak, T Heitzer, T Renné, VT Turitto, VT Turitto, WA Schumacher, WS Nesbitt, X Wang, Y Yano, YC Lau, ZM Ruggeri   +66 more
core   +2 more sources

Platelet aggregometry assay for evaluating the effects of platelet agonists and antiplatelet compounds on platelet function in vitro

MethodsX, 2019
Platelet aggregometry assays are generally used for the analysis of platelet function but can also be adapted for further research and therapy focused applications.
Alexandros Tsoupras, Ioannis Zabetakis, Ronan Lordan   +2 more
doaj   +1 more source

Platelet-Activating Factor Induces Th17 Cell Differentiation

Mediators of Inflammation, 2011
Th17 cells have been implicated in a number of inflammatory and autoimmune diseases. The phospholipid mediator platelet-activating factor (PAF) is found in increased concentrations in inflammatory lesions and has been shown to induce IL-6 production.
Anne-Marie Drolet, Maryse Thivierge, Sylvie Turcotte, Dominique Hanna, Bruno Maynard, Jana Stankovà, Marek Rola-Pleszczynski   +6 more
doaj   +1 more source

Design, Synthesis and Anti-Platelet Aggregation Activity Study of Ginkgolide-1,2,3-triazole Derivatives

Molecules, 2019
Ginkgolides are the major active component of Ginkgo biloba for inhibition of platelet activating factor receptor. An azide-alkyne Huisgen cycloaddition reaction was used to introduce a triazole nucleus into the target ginkgolide molecules.
Jian Cui, Le’An Hu, Wei Shi, Guozhen Cui, Xumu Zhang, Qing-Wen Zhang   +5 more
doaj   +1 more source

Fenofibrate induces HDL-associated PAF-AH but attenuates enzyme activity associated with apoB-containing lipoproteins

Journal of Lipid Research, 2003
Human plasma platelet-activating factor acetylhydrolase (PAF-AH) is an enzyme associated mainly with the apolipoprotein B (apoB)-containing lipoproteins and primarily with LDL. A small proportion of enzymatic activity is also associated with HDL.
Vasilis Tsimihodimos, Anna Kakafika, Afroditi P. Tambaki, Eleni Bairaktari, M.John Chapman, Moses Elisaf, Alexandros D. Tselepis   +6 more
doaj   +1 more source

Levels of thrombin-activatable fibrinolysis inhibitor and platelet-activating factor in recurrent pregnancy loss patients

Taiwanese Journal of Obstetrics & Gynecology, 2016
Objective: The aim of this study was to investigate factors associated with thrombosis that may contribute to recurrent pregnancy loss (habitual abortion), specifically differences in serum levels of platelet-activating factor and thrombin-activatable ...
Ayla Eser, Ilknur Inegol Gumus, Husamettin Erdamar, Ikbal Kaygusuz, Melahat Yildirim, Betul Usluogullari, Muzeyyen Duran Erdolu, Serap Aynur Simavli, Ramazan Yigitoglu, Nilgun Ozturk Turhan   +9 more
doaj   +1 more source

Generation of specific antibodies against the rap1A, rap1B and rap2 small GTP-binding proteins. Analysis of rap and ras proteins in membranes from mammalian cells [PDF]

, 1992
Specific antibodies against rap1A and rap1B small GTP-binding proteins were generated by immunization of rabbits with peptides derived from the C-terminus of the processed proteins.
Frank, R., Gausepohl, H., Klinz, F. J., Schultz, Günter, Schwaner, I., Seifert, Roland   +5 more
core   +1 more source

Role of growth factors in the pathogenesis of tissue fibrosis in systemic sclerosis. [PDF]

, 2010
The most severe clinical and pathologic manifestations of systemic sclerosis (SSc) are the result of a fibrotic process characterized by the excessive and often progressive deposition of collagen and other connective tissue macromolecules in skin and ...
Castro, Susan V., Jimenez, Sergio A., Piera-Velazquez, Sonsoles   +2 more
core   +2 more sources

Class A CpG Oligonucleotide Priming Rescues Mice from Septic Shock via Activation of Platelet-Activating Factor Acetylhydrolase

Frontiers in Immunology, 2017
Sepsis is a life-threatening, overwhelming immune response to infection with high morbidity and mortality. Inflammatory response and blood clotting are caused by sepsis, which induces serious organ damage and death from shock.
Yoshinari Yamamoto, Yoshinari Yamamoto, Ryu Sugimura, Takafumi Watanabe, Suguru Shigemori, Suguru Shigemori, Takuma Okajima, Shireen Nigar, Shireen Nigar, Fu Namai, Takashi Sato, Tasuku Ogita, Takeshi Shimosato, Takeshi Shimosato   +13 more
doaj   +1 more source