Results 91 to 100 of about 4,119,343 (427)

Integrating platelet and coagulation activation in fibrin clot formation

Research and Practice in Thrombosis and Haemostasis, 2018
Platelets interact with the coagulation system in a multitude of ways, not only during the phases of thrombus formation, but also in specific areas within a formed thrombus.
F. Swieringa, H. Spronk, J. Heemskerk, P. V. D. van der Meijden   +3 more
semanticscholar   +1 more source

Platelet adhesion and degranulation induce pro-survival and pro-angiogenic signalling in ovarian cancer cells [PDF]

, 2011
Thrombosis is common in ovarian cancer. However, the interaction of platelets with ovarian cancer cells has not been critically examined. To address this, we investigated platelet interactions in a range of ovarian cancer cell lines with different ...
Berndt, Michael, Berndt, Michael, Canney, A., Conlon, N., Crowley, D., Dermot, K., Ducree, J., Dunne, E., Egan, K., Ffrench, B., Finn, S., Gallagher, M., Keegan, H., Laios, A., Martin, C., McEneaney, V., McEvoy, L., Norris, L., O'Leary, J., O'Toole, S., Sheils, O., Smith, L., Smyth, P., Spillane, C., Stordal, B.   +24 more
core   +5 more sources

Src family kinases: at the forefront of platelet activation.

Blood, 2014
Src family kinases (SFKs) play a central role in mediating the rapid response of platelets to vascular injury. They transmit activation signals from a diverse repertoire of platelet surface receptors, including the integrin αIIbβ3, the immunoreceptor ...
Y. Senis, A. Mazharian, J. Mori
semanticscholar   +1 more source

Platelet Isolation and Activation Assays [PDF]

BIO-PROTOCOL, 2019
Platelets regulate hemostasis and are the key determinants of pathogenic thrombosis following atherosclerotic plaque rupture. Platelets circulate in an inactive state, but become activated in response to damage to the endothelium, which exposes thrombogenic material such as collagen to the blood flow.
Burzynski, Laura C, Pugh, Nicholas, Clarke, Murray CH   +2 more
openaire   +6 more sources

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

A Mathematical Model of Platelet Aggregation in an Extravascular Injury Under Flow [PDF]

arXiv, 2020
We present the first mathematical model of flow-mediated primary hemostasis in an extravascular injury, which can track the process from initial deposition to occlusion. The model consists of a system of ordinary differential equations (ODE) that describe platelet aggregation (adhesion and cohesion), soluble-agonist-dependent platelet activation, and ...
arxiv  

Minimal regulation of platelet activity by PECAM-1 [PDF]

, 2007
PECAM-1 is a member of the superfamily of immunoglobulins (Ig) and is expressed on platelets at moderate level. PECAM-1 has been reported to have contrasting effects on platelet activation by the collagen receptor GPVI and the integrin, αIIbβ3, even ...
Asselin J, Berman ME, Berman ME, Chiba R, Cicmil M, Cines DB, Craig E. Hughes, Duncan GS, Ewan A. Ross, Falati S, FitzGerald GA, Gurubhagavatula I, Haslam RJ, Jackson DE, Jensen BO, Jocelyn M. Auger, Muller WA, Newman DK, Newman PJ, Newton-Nash DK, Nixon B, O'Brien CD, Owen J. T. Mccarty, Pratico D, Rathore V, Reedquist KA, Steve P. Watson, Sun QH, Tarvinder S. Dhanjal, Varon D, Vollmar B, Wee JL, Yotis A. Senis   +32 more
core   +1 more source

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

Caracterização da ativação plaquetária nos concentrados de plaquetas por citometria de fluxo

Revista Brasileira de Hematologia e Hemoterapia, 2003
Flow cytometric characterization of platelet membrane glycoproteins expression and procoagulant surface is a sensitive technique to identify platelet activation in platelet concentrates.
Landi Evaldo P., Marques Júnior José F. C.   +1 more
doaj  

Platelet activation determines angiopoietin-1 and VEGF levels in malaria: implications for their use as biomarkers. [PDF]

PLoS ONE, 2014
INTRODUCTION: The angiogenic proteins angiopoietin (Ang)-1, Ang-2 and vascular endothelial growth factor (VEGF) are regulators of endothelial inflammation and integrity.
Judith Brouwers, Rintis Noviyanti, Rob Fijnheer, Philip G de Groot, Leily Trianty, Siti Mudaliana, Mark Roest, Din Syafruddin, Andre van der Ven, Quirijn de Mast   +9 more
doaj   +1 more source