Results 111 to 120 of about 4,119,343 (427)

Functional redundancy between RAP1 isoforms in murine platelet production and function [PDF]

, 2018
RAP GTPases, important regulators of cellular adhesion, are abundant signaling molecules in the platelet/megakaryocytic lineage. However, mice lacking the predominant isoform, RAP1B, display a partial platelet integrin activation defect and have a ...
Becker, Bergmeier, Bermejo, Bertozzi, Bertozzi, Bokoch, Bos, Boudreaux, Boulaftali, Boulaftali, Bouschet, Burkhart, Canault, Cattaneo, Christopher I. Jones, Chrzanowska-Wodnicka, Chrzanowska-Wodnicka, Crittenden, Dan O. Kechele, David S. Paul, Deppermann, Dorsaf Ghalloussi, Durrant, Ellen C. O'Shaughnessy, Eto, Garcia, Getz, Gloerich, Goerge, Gros, Han, Ho-Tin-Noé, Jonathan M. Gibbins, Kamata, Kamata, Kasirer-Friede, Kathleen M. Caron, Kathryn O. Poe, Kato, Klapproth, Klaus M. Hahn, Lee, Lee, Lenter, Li, Li, Lin, Lozano, Lucia Stefanini, Mazharian, Molina-Ortiz, Moore, Moser, Nieswandt, Nieswandt, Nonaka, Pan, Petrich, Piatt, Pleines, Qu, Raaijmakers, Raymond Piatt, Robert H. Lee, Rowley, Shattil, Simon, Stalker, Stefanini, Stefanini, Stefanini, Stefanini, Stefanini, Stolla, Stork, Stritt, Su, Suzuki-Inoue, Séverin, Taira, Tiedt, Wang, Watanabe, Watkins, Westbury, Wittchen, Wolfgang Bergmeier, Yacine Boulaftali, Yue, Zeiler, Zhang, Zhu   +91 more
core   +1 more source

Platelet Activation and Apoptosis Modulate Monocyte Inflammatory Responses in Dengue

Journal of Immunology, 2014
Dengue is the most prevalent human arbovirus disease in the world. Dengue infection has a large spectrum of clinical manifestations, from self-limited febrile illness to severe syndromes accompanied by bleeding and shock.
E. D. Hottz, I. M. Medeiros-de-Moraes, A. Vieira‐de‐Abreu, Edson F de Assis, Rogério Vals-de-Souza, H. Castro-Faria-Neto, A. Weyrich, G. Zimmerman, F. Bozza, P. Bozza   +9 more
semanticscholar   +1 more source

Platelet-Derived Inhibitors of Platelet Activation [PDF]

, 2017
Negative regulators of platelet activation are a relatively unexplored aspect of platelet physiology yet have an important role in tempering thrombus development by contributing much needed negative regulation to a process that is amplified by several positive feedback mechanisms.
Unsworth, AJ, Bye, AP, Gibbins, JM
openaire   +2 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Tryptophan‐sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin‐producing cells

FEBS Open Bio, EarlyView.
GPR142, a tryptophan‐sensing receptor, stimulates gastrointestinal hormones like ghrelin and is linked to inflammation regulation. Proinflammatory cytokines suppress ghrelin production, while tryptophan levels decrease via IDO1 activation. Our findings reveal that proinflammatory cytokines directly regulate GPR142 expression in ghrelin‐producing cells,
Yoko Ueda, Hiroshi Iwakura, Takuya Ensho, Mika Bando‐Shimizu, Asako Doi, Norihiko Matsutani, Shuhei Morita, Hidefumi Inaba, Hiroyuki Ariyasu, Naoki Fukuda, Keiji Hayata, Toshiyasu Ojima, Masahiro Nishi, Taka‐aki Matsuoka, Hiroki Yamaue, Takashi Akamizu   +15 more
wiley   +1 more source

Twenty-four-hour time dependency of clopidogrel effects in patients with acute coronary syndromes: The CiCAD-Study

Platelets, 2019
Long-term evidence shows an increased risk of cardiovascular events in the morning hours and recent studies in aspirin-treated patients have shown increased platelet reactivity at the end of the dosing interval.
Susanne Claudia Gruber, Matthias Karl Freynhofer, Martin Willheim, Thomas Werner Weiss, Florian Egger, Wolfgang Hübl, Kurt Huber   +6 more
doaj   +1 more source

Dynamic Formation of Preferentially Lattice Oriented, Self Trapped Hydrogen Clusters [PDF]

arXiv, 2023
A series of MD and DFT simulations were performed to investigate hydrogen self-clustering and retention in tungsten. Using a newly develop machine learned interatomic potential, spontaneous formation of hydrogen platelets was observed after implanting low-energy hydrogen into tungsten at high fluxes and temperatures.
arxiv  

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Aspirin Attenuates Platelet Activation and Immune Activation in HIV-1-Infected Subjects on Antiretroviral Therapy: A Pilot Study

Journal of Acquired Immune Deficiency Syndromes, 2013
Background:Mechanisms for increased cardiovascular risk in HIV-1-infected adults are incompletely understood, but platelet activation and immune activation leading to a prothrombotic state have been proposed as significant contributors.
Meagan P. O’Brien, E. Montenont, Liang Hu, M. Nardi, V. Valdes, M. Merolla, G. Gettenberg, Karen Cavanagh, J. Aberg, N. Bhardwaj, J. Berger   +10 more
semanticscholar   +1 more source

Idiopathic Pulmonary Fibrosis Caused by Damaged Mitochondria and Imbalanced Protein Homeostasis in Alveolar Epithelial Type II Cell

Advanced Biology, EarlyView.
By systematizing a large body of evidence and propose a cascade relationship between protein homeostasis, endoplasmic reticulum stress, mitochondrial dysfunction, and pro‐fibrotic factor, providing a theoretical basis for ATII cells dysfunction as a possible pathophysiological initiating event for idiopathic pulmonary fibrosis.
Zhaoxiong Dong, Xiaolong Wang, Peiwen Wang, Mingjian Bai, Tianyu Wang, Yanhui Chu, Yan Qin   +6 more
wiley   +1 more source