Results 131 to 140 of about 287,515 (269)

Interferon receptor gene dosage differentially regulates hypoxia-induced platelet activation and pulmonary hypertension in down syndrome. [PDF]

Front Immunol
Posey JN, Jordan M, Olsen-Dufour A, Nguyen TN, Farrell C, Lewis CV, Archambault JL, Sul C, Colon-Hidalgo D, Nozik ES, Espinosa JM, Sullivan KD, Delaney C.   +12 more
europepmc   +1 more source

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Advanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song   +15 more
wiley   +1 more source

Mitochondrial oxidants promote platelet activation and thrombotic susceptibility in prediabetes. [PDF]

J Clin Invest
Ahmed A, Yadav P, Jensen M, Geasland K, Swamy J, Spitz DR, Abel ED, Jalal D, Dayal S.   +8 more
europepmc   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Effects of Cape Cobra (<i>Naja nivea</i>) Venom and Its Isolated Protein on the Modulation of Platelet Activation. [PDF]

Toxins (Basel)
Khatibi M, Almeida JR, Al Juwaiser A, Gilabadi S, Patel K, Vaiyapuri S.   +5 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

VLX-1005, but not argatroban, prevents ITAM-mediated platelet activation and heparin-induced thrombocytopenia. [PDF]

Blood Vessel Thromb Hemost
Yamaguchi A, Putzbach V, Adili R, Lazar S, Stanger L, Gilmore D, Maloney DJ, McKenzie SE, Michael JV, Holinstat M.   +9 more
europepmc   +1 more source

FGL2‐HDAC11 Drives Immunothrombosis via NETs‐Mediated Endothelial Capillarization in MASLD Fibrosis

Advanced Science, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is frequently accompanied by hepatic fibrosis and systemic cardiovascular complications; however, the mechanistic interplay between coagulation abnormalities and disease progression remains poorly defined.
Xitang Li, Junjian Hu, Suping Hai, Peng Hu, Wenhui Wu, Qiang Gao, Binghui Yu, Feiyang Xu, Xizhe Zheng, Qianting Guan, Huiling Xiang, Dong Xi, Weiming Yan, Peng Wang, Bin‐hao Zhang, Qin Ning, Xiaojing Wang   +16 more
wiley   +1 more source

Murine thrombus organization limits access to high platelet activation states while supporting platelet recruitment. [PDF]

Blood Vessel Thromb Hemost
Rhee SW, Pokrovskaya ID, Ball KK, Webb MW, Kamykowski JA, Aronova MA, Leapman RD, Driehaus ER, Franz ES, Whiteheart SW, Storrie B.   +10 more
europepmc   +1 more source

Large‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens

Advanced Science, EarlyView.
Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao, Ruixue Nie, Hailu Fan, Tenzin Ngodroup, Li Zhu, Hongbin Pan, Bo Zhang, Hao Zhang   +7 more
wiley   +1 more source