Results 151 to 160 of about 4,071,532 (408)

Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction [PDF]

open access: yes, 2018
The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone.
Bye, Alex P.   +6 more
core   +4 more sources

Effects of Chemical Pressure on Superconductivity in Electrochemically Intercalated (TMA)yFe2(Se1−xSx)2 (TMA = Tetramethylammonium)

open access: yesAdvanced Functional Materials, EarlyView.
Intercalation of a series of FeSe1−xSx host crystals with tetramethylammonium cations (TMA+) linearly scales the critical temperature Tc from 43 K down to 28 K with increasing sulfur incorporation. The chemical pressure induced by the partial substitution shows a weakening of the superconducting properties in both hosts and intercalates in a remarkably
Nadine Lammer   +3 more
wiley   +1 more source

Role of platelets and platelet receptors in cancer metastasis

open access: yesJournal of Hematology & Oncology, 2018
The interaction of tumor cells with platelets is a prerequisite for successful hematogenous metastatic dissemination. Upon tumor cell arrival in the blood, tumor cells immediately activate platelets to form a permissive microenvironment.
M. Schlesinger
semanticscholar   +1 more source

Defective ADP-Induced Platelet Factor 3 Activation in Uremia [PDF]

open access: bronze, 1967
Herbert I. Horowitz   +3 more
openalex   +1 more source

Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy

open access: yesAdvanced Functional Materials, EarlyView.
MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee   +6 more
wiley   +1 more source

Modulation of Platelet Activation by Native DNA [PDF]

open access: bronze, 1979
B A Fiedel   +2 more
openalex   +1 more source

Cyclic nucleotides and mitogen-activated protein kinases: regulation of simvastatin in platelet activation

open access: yesJournal of Biomedical Science, 2010
Background 3-Hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have been widely used to reduce cardiovascular risk. These statins (i.e., simvastatin) may exert other effects besides from their cholesterol-lowering actions ...
Hou Ssu-Yu   +7 more
doaj   +1 more source

Platelet-Induced Clumping of Plasmodium falciparum–Infected Erythrocytes from Malawian Patients with Cerebral Malaria—Possible Modulation In Vivo by Thrombocytopenia [PDF]

open access: yes, 2008
Platelets may play a role in the pathogenesis of human cerebral malaria (CM), and they have been shown to induce clumping of Plasmodium falciparum–parasitized red blood cells (PRBCs) in vitro.
Barnwell JW   +18 more
core   +1 more source

Bi‐Directional Assembly of Boron Nitride µ‐Platelets by Micro‐Molding for Advanced Thermal Interface Materials

open access: yesAdvanced Functional Materials, EarlyView.
Bi‐directionally assembled BN µ‐platelets in micropatterns formed by a micro‐molding method for thermal interface materials are demonstrated. The BN µ‐platelets are vertically aligned selectively, while compressed regions without patterns accommodate horizontally assembled BN µ‐platelets. Through anisotropic orientation, high thermal conductivities for
Young Gil Kim   +12 more
wiley   +1 more source

Nanoparticle biointerfacing via platelet membrane cloaking

open access: yesNature, 2015
Development of functional nanoparticles can be encumbered by unanticipated material properties and biological events, which can affect nanoparticle effectiveness in complex, physiologically relevant systems.
C. J. Hu   +21 more
semanticscholar   +1 more source

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