Results 271 to 280 of about 291,045 (316)
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Seminal Platelet-Activating Factor
Seminars in Thrombosis and Hemostasis, 2007Platelet-activating factor (PAF; 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphorylcholine) is a potent signaling phospholipid with pleiotropic biologic activities. Since its discovery more than 30 years ago, numerous investigators have documented its presence in a variety of tissues.
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Platelet-activating factor antagonists
Clinical Reviews in Allergy, 1995The great number of PAF antagonists reviewed in this article clearly shows the tremendous effort made in the last 20 yr to explore the complex biological background of the mechanism of action of PAF and the potential clinical benefit of its antagonists. It is obvious that now highly potent, long-acting, and perorally applicable PAF-receptor antagonists
M, Koltai, P G, Braquet
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Platelet activation by heparin
Blood, 2011In this issue of Blood , Gao et al provide important insights into the proactivating effects of negatively charged anticoagulants on platelets.[1][1] They show outside-in signaling via the glycoprotein (GP) IIb-IIIa complex (integrin αIIbβ3) induced by heparin, low molecular weight heparin ...
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Blood reviews, 1996
This review article describes the different receptors, second-messengers and mechanisms involved in platelet activation. Several platelet agonists have well-defined receptors at the platelet membrane of which a number are single polypeptides with 7 hydrophobic transmembrane domains.
D, Blockmans, H, Deckmyn, J, Vermylen
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This review article describes the different receptors, second-messengers and mechanisms involved in platelet activation. Several platelet agonists have well-defined receptors at the platelet membrane of which a number are single polypeptides with 7 hydrophobic transmembrane domains.
D, Blockmans, H, Deckmyn, J, Vermylen
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Human Platelet Activating Antibodies
Seminars in Thrombosis and Hemostasis, 1992Platelet antibodies identified in the plasma of three multiply transfused patients and a woman who had delivered a baby with neonatal alloimmune thrombocytopenia were investigated for their platelet activating properties. Three patients possessed multispecific HLA antibodies reactive with 90 to 100% of the cells on a lymphocytotoxic panel.
D J, Christie, C D, Swinehart
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Platelet Activation: New Aspects
Pathophysiology of Haemostasis and Thrombosis, 1996Work on growth factor receptors in other cells has led to the concept that tyrosine phosphorylation of receptor cytoplasmic domains leads to recruitment of signaling molecules to appropriate sub-membrane locations. Complexes of molecules are assembled through structural motifs that mediate phosphotyrosine-SH2 domain and SH3-proline-rich domain ...
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Headache: The Journal of Head and Face Pain, 1982
SYNOPSIS Migraine is a disease associated with increased platelet activity. The aim of this paper was to study "in vivo" platelet activation by assessing platelet serotonin (5HT) content and beta‐thromboglobulin (B‐TG) and platelet factor four (PF4) plasma levels, in headache‐free‐periods and during migraine attacks.
G, D'Andrea +3 more
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SYNOPSIS Migraine is a disease associated with increased platelet activity. The aim of this paper was to study "in vivo" platelet activation by assessing platelet serotonin (5HT) content and beta‐thromboglobulin (B‐TG) and platelet factor four (PF4) plasma levels, in headache‐free‐periods and during migraine attacks.
G, D'Andrea +3 more
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Platelet Activating Factor Receptors
2003Platelet activating factor (PAF) is a potent pro-inflammatory lipid mediator. Its effects are mediated through cell surface G protein-coupled receptors (GPCRs) that are distributed on numerous cells notably on endothelium [1]. An intracrine mode of action for PAF is proposed based on evidence for intracellular PAF binding sites [2] and retention of ...
A Marilise, Marrache +15 more
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Stress and Platelet Activation
Acta Haematologica, 1983Severe stress, with increased secretion of adrenaline, is likely to cause platelet activation. The aim of the present study was to investigate if moderate stress, which usually is not accompanied by adrenaline secretion, could induce activation of platelets, as measured by changes in the plasma concentrations of platelet factor 4 (PF-4).
L, Andrén +3 more
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Platelet Activating Factor and Platelets
1999Among agents which activate platelets PAF is unique since it is the only phospholipid known to date which stimulates platelets at nanomolar range. The first indications of such a mediator dates back to 1966 when it was observed that a mixture of rabbit platelets and stimulated leukocytes released histamine on specific antigen challenge (Barbaro and ...
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