Results 61 to 70 of about 491,468 (315)

Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function

Cell Reports, 2017
Anucleate platelets circulate in the blood to facilitate thrombosis and diverse immune functions. Platelet activation leading to clot formation correlates with increased glycogenolysis, glucose uptake, glucose oxidation, and lactic acid production ...
Trevor P. Fidler, Robert A. Campbell, Trevor Funari, Nicholas Dunne, Enrique Balderas Angeles, Elizabeth A. Middleton, Dipayan Chaudhuri, Andrew S. Weyrch, E. Dale Abel   +8 more
doaj   +1 more source

Evolution of platelet activation parameters during septic shock in intensive care unit

Platelets, 2022
During severe sepsis, platelet activation may induce disseminate microvascular thrombosis, which play a key role in critical organ failure. Crucially, most of the studies in this field have explored platelet–leukocyte interactions in animal models, or ...
Fanny Vardon-Bounes, Cédric Garcia, Alexandra Piton, Jennifer Series, Marie-Pierre Gratacap, Michaël Poëtte, Thierry Seguin, Laure Crognier, Stéphanie Ruiz, Stein Silva, Jean-Marie Conil, Vincent Minville, Bernard Payrastre   +12 more
doaj   +1 more source

Biomarkers in acute coronary syndromes and their role in diabetic patients [PDF]

, 2005
Diabetic patients with acute coronary syndromes are at high risk for cardiovascular complications but risk stratification in these patients remains challenging.
Christopher Heeschen, Heeschen C, James SK, Khaliq A, Luttun A, Mak KH   +5 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Effects of High Flavanol Dark Chocolate on Cardiovascular Function and Platelet Aggregation. [PDF]

, 2015
Regular consumption of chocolate and cocoa products has been linked to reduced cardiovascular mortality. This study compared the effects of high flavanol dark chocolate (HFDC; 1064mg flavanols/day for 6 weeks) and low flavanol dark chocolate (LFDC; 88mg ...
Akita, Armstrong, Atholl Johnston, Avolio, Balzer, Buijsse, Buijsse, Butcher, Curtis, Curtis, Custodis, David J. Collier, Duprez, Engler, Flammer, Flammer, Fredholm, Grassi, Grassi, Gresele, Gu, Gurvinder Rull, Heiss, Hermann, Holland, Holt, Innes, Janszky, Julian Shiel, Kokubo, Kris-Etherton, Kris-Etherton, Lakatta, Langer, Larsson, Larsson, Laurent, Lopez-Garcia, Manisty, Martina H. Lundberg, Murphy, Pereira, Rambaran, Rein, Ried, Roger Corder, Schroeter, Sever, Sharman, Smolenski, Taubert, Thorin, Timothy D. Warner, Varughese, Williams, Yu, Zetty N. Mohd-Zain   +56 more
core   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Platelets promote macrophage polarization toward pro-inflammatory phenotype and increase survival of septic mice [PDF]

, 2019
We investigated the contribution of human platelets to macrophage effector properties in the presence of lipopolysaccharide (LPS), as well as the beneficial effects and time frame for platelet transfusion in septic animals.
Carestia, Agostina, Carrera Silva, Eugenio Antonio, Errasti, Andrea Emilse, Gomez, Ricardo Martin, Jenne, Craig N., Mena, Hebe Agustina, Negrotto, Soledad, Olexen, Cinthia Mariel, Ortiz Wilczyñski, Juan Manuel, Schattner, Mirta Ana   +9 more
core   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Entecavir as a P2X7R antagonist ameliorates platelet activation and thrombus formation

Journal of Pharmacological Sciences, 2020
Platelet activation is the primary cause of thrombosis. The P2X7 receptor (P2X7R) is a therapeutic target of thrombosis. However, it is still unknown whether P2X7R activation affects platelet thrombus.
Yue Ming, Guang Xin, Beihong Ji, Chengji Ji, Zeliang Wei, Boli Zhang, Junhua Zhang, Kui Yu, Xiaoyu Zhang, Shiyi Li, Youping Li, Zhihua Xing, Hai Niu, Wen Huang   +13 more
doaj   +1 more source

Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor. [PDF]

, 1992
We recently isolated a cDNA clone encoding a functional platelet thrombin receptor that defined a unique mechanism of receptor activation. Thrombin cleaves its receptor's extracellular amino terminal extension, unmasking a new amino terminus that ...
Coughlin, SR, Hung, DT, Nelken, NA, Vu, TH   +3 more
core   +1 more source