Results 61 to 70 of about 4,071,532 (408)

The effects of signal transducer and activator of transcription three mutations on human platelets

Platelets, 2018
Involvement of signal transducer and activator of transcription 3 (STAT3) in inflammation is well known. Recently, a role for STAT3 in platelet activation and platelet production has been suggested.
Floor E. Aleva, Frank L. van de Veerdonk, Yang Li, Rahajeng N. Tunjungputri, Sami Simons, Philip G. De Groot, Mihai M. Netea, Yvonne F. Heijdra, Quirijn de Mast, André J.A.M. van der Ven   +9 more
doaj   +1 more source

Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation [PDF]

, 2005
Oxidation of low-density lipoprotein (LDL) generates proinflammatory and prothrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases.
Berliner JA, Bittman R, Casals-Stenzal J, Esterbauer H, Fernandez-Ortiz A, Frey B, Goetzl EJ, Holvoet P, Itabe H, Kamido H, Kamido H, Kern H, Kinsella BT, Kitagawa S, O'Flaherty JT, O'Flaherty JT, Rasmussen UB, Sevanian A, Subbanagounder G, Tanaka T, Trip MD, Volf I, Watson AD, Weidtmann A   +23 more
core   +1 more source

Left ventricular assist device implantation causes platelet dysfunction and proinflammatory platelet-neutrophil interaction

Platelets, 2022
Blood flow through left ventricular assist devices (LVAD) may induce activation and dysfunction of platelets. Dysfunctional platelets cause coagulation disturbances and form platelet-neutrophil conjugates (PNC), which contribute to inflammatory tissue ...
Tiago Granja, Harry Magunia, Patricia Schüssel, Claudius Fischer, Thomas Prüfer, David Schibilsky, Lina Serna-Higuita, Hans Peter Wendel, Christian Schlensak, Helene Häberle, Peter Rosenberger, Andreas Straub   +11 more
doaj   +1 more source

Platelet activation via dynamic conformational changes of von Willebrand factor under shear.

PLoS ONE, 2020
Shear-induced conformational changes of von Willebrand factor (VWF) play an important role in platelet activation. A novel approach describing VWF unfolding on the platelet surface under dynamic shear stress is proposed.
Denis M Pushin, Tatiana Y Salikhova, Ksenia E Zlobina, Georgy Th Guria   +3 more
doaj   +1 more source

Evolution of platelet activation parameters during septic shock in intensive care unit

Platelets, 2022
During severe sepsis, platelet activation may induce disseminate microvascular thrombosis, which play a key role in critical organ failure. Crucially, most of the studies in this field have explored platelet–leukocyte interactions in animal models, or ...
Fanny Vardon-Bounes, Cédric Garcia, Alexandra Piton, Jennifer Series, Marie-Pierre Gratacap, Michaël Poëtte, Thierry Seguin, Laure Crognier, Stéphanie Ruiz, Stein Silva, Jean-Marie Conil, Vincent Minville, Bernard Payrastre   +12 more
doaj   +1 more source

Zinc is a transmembrane agonist that induces platelet activation in a tyrosine phosphorylation-dependent manner [PDF]

, 2015
Following platelet adhesion and primary activation at sites of vascular injury, secondary platelet activation is induced by soluble platelet agonists, such as ADP, ATP, thrombin and thromboxane.
Asselin, Ben R. Watson, Blake, Dominique Bihan, Emery, Faure, Forbes, Gibbins, Gibbins, Golden, Gordon, Gorodetsky, Heyns Adu, Jarvis, Jean-Daniel M. Malcor, Joanna-Marie Howes, Jung, Kehrel, Kirk A. Taylor, Knight, Konopatskaya, Mahdi, Marx, Marx, Milne, Morton, Nathan A. White, Nicholas Pugh, Onley, Pugh, Pugh, Raynal, Richard W. Farndale, Ruggeri, Sharir, Smethurst, Stadler, Stefanini, Stewart O. Sage, Trybulec, Vallee, Varga-Szabo, Xia, Zhang, Zufferey   +44 more
core   +1 more source

RASA3 is a critical inhibitor of RAP1-dependent platelet activation.

Journal of Clinical Investigation, 2015
The small GTPase RAP1 is critical for platelet activation and thrombus formation. RAP1 activity in platelets is controlled by the GEF CalDAG-GEFI and an unknown regulator that operates downstream of the adenosine diphosphate (ADP) receptor, P2Y12, a ...
L. Stefanini, David S. Paul, R. Robledo, E. R. Chan, T. Getz, Robert A. Campbell, Daniel O. Kechele, C. Casari, Raymond Piatt, K. Caron, N. Mackman, A. Weyrich, M. C. Parrott, Y. Boulaftali, M. Adams, L. Peters, W. Bergmeier   +16 more
semanticscholar   +1 more source

Platelet adhesion and degranulation induce pro-survival and pro-angiogenic signalling in ovarian cancer cells [PDF]

, 2011
Thrombosis is common in ovarian cancer. However, the interaction of platelets with ovarian cancer cells has not been critically examined. To address this, we investigated platelet interactions in a range of ovarian cancer cell lines with different ...
Berndt, Michael, Berndt, Michael, Canney, A., Conlon, N., Crowley, D., Dermot, K., Ducree, J., Dunne, E., Egan, K., Ffrench, B., Finn, S., Gallagher, M., Keegan, H., Laios, A., Martin, C., McEneaney, V., McEvoy, L., Norris, L., O'Leary, J., O'Toole, S., Sheils, O., Smith, L., Smyth, P., Spillane, C., Stordal, B.   +24 more
core   +3 more sources

Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis.

Blood, 2015
Autophagy is important for maintaining cellular homeostasis, and thus its deficiency is implicated in a broad spectrum of human diseases. Its role in platelet function has only recently been examined.
Madhu M Ouseph, Yunjie Huang, M. Banerjee, Smita Joshi, L. MacDonald, Yu Zhong, Huijuan Liu, Xianting Li, B. Xiang, Guoying Zhang, M. Komatsu, Zhenyu Yue, Zhenyu Li, B. Storrie, S. Whiteheart, Qing Jun Wang   +15 more
semanticscholar   +1 more source

Gradient-dependent inhibition of stimulatory signaling from platelet G protein-coupled receptors [PDF]

, 2019
As platelet activation is an irreversible and potentially harmful event, platelet stimulatory signaling must be tightly regulated to ensure the filtering-out of inconsequential fluctuations of agonist concentrations in the vascular milieu.
Boknas, Niklas, Faxalv, Lars, Gibbins, Jonathan M., Lindahl, Tomas L., Macwan, Ankit S., Ntzouni, Maria P., Ramstrom, Sofia   +6 more
core   +2 more sources