Results 61 to 70 of about 4,119,343 (427)
Underlying mechanism and specific prevention of hemolysis-induced platelet activation
Platelets, 2017 Thromboembolic complications significantly impair the outcome of hemolytic disorders. We hypothesized that red cell adenosine diphosphate (ADP) release results in significant platelet activation in hemolysis and that this prothrombotic state can be ...
Thomas Gremmel +4 more
doaj +1 more source
Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein [PDF]
, 2006 Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that play a crucial role in cardiovascular and inflammatory diseases.
Siess, Wolfgang
core +1 more source
World Journal of Psychiatry, 2016 Brain-derived neurotrophic factor (BDNF) plays an important role in central nervous system development, neurogenesis and neuronal plasticity. BDNF is also expressed in several non-neuronal tissues, and it could play an important role in other processes ...
Montserrat Serra-Millàs
semanticscholar +1 more source
Platelet activation via dynamic conformational changes of von Willebrand factor under shear.
PLoS ONE, 2020 Shear-induced conformational changes of von Willebrand factor (VWF) play an important role in platelet activation. A novel approach describing VWF unfolding on the platelet surface under dynamic shear stress is proposed.
Denis M Pushin +3 more
doaj +1 more source
Platelets, 2022 Blood flow through left ventricular assist devices (LVAD) may induce activation and dysfunction of platelets. Dysfunctional platelets cause coagulation disturbances and form platelet-neutrophil conjugates (PNC), which contribute to inflammatory tissue ...
Tiago Granja +11 more
doaj +1 more source
Bioengineering, 2023 Introduction: Obstructive sleep apnea (OSA) and loud snoring are conditions with increased cardiovascular risk and notably an association with stroke.
Daniel E. Palomares +8 more
doaj +1 more source
FluidFM-Based Fabrication of Nanopatterns: Promising Surfaces for Platelet Storage Application [PDF]
, 2022 Platelets are cell fragments from megakaryocytes devoid of the cell nucleus. They are highly sensitive and easily activated by nonphysiological surfaces.
Apte, Gurunath +2 more
core +2 more sources
Evolution of platelet activation parameters during septic shock in intensive care unit
Platelets, 2022 During severe sepsis, platelet activation may induce disseminate microvascular thrombosis, which play a key role in critical organ failure. Crucially, most of the studies in this field have explored platelet–leukocyte interactions in animal models, or ...
Fanny Vardon-Bounes +12 more
doaj +1 more source
Three-dimensional Multiscale Model of Deformable Platelets Adhesion to Vessel Wall in Blood Flow [PDF]
, 2013 When a blood vessel ruptures or gets inflamed, the human body responds by rapidly forming a clot to restrict the loss of blood. Platelets aggregation at the injury site of the blood vessel occurring via platelet-platelet adhesion, tethering and rolling on the injured endothelium is a critical initial step in blood clot formation.
arxiv +1 more source
Zinc is a transmembrane agonist that induces platelet activation in a tyrosine phosphorylation-dependent manner [PDF]
, 2015 Following platelet adhesion and primary activation at sites of vascular injury, secondary platelet activation is induced by soluble platelet agonists, such as ADP, ATP, thrombin and thromboxane.
Asselin +44 more
core +1 more source