Results 81 to 90 of about 4,071,532 (408)

Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation [PDF]

open access: yes, 2008
The activation of initiator protein tissue factor (TF) is likely to be a crucial step in the blood coagulation process, which leads to fibrin formation. The stimuli responsible for inducing TF activation are largely undefined.
Altmann, Berid   +13 more
core   +3 more sources

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi   +3 more
wiley   +1 more source

Platelet microparticles sustain autophagy-associated activation of neutrophils in systemic sclerosis

open access: yesScience Translational Medicine, 2018
Platelet microparticles from patients with systemic sclerosis prompt endothelial cell activation, neutrophil recruitment, and lung fibrosis. Platelets nurture neutrophil damage Systemic sclerosis, or scleroderma, is a complicated inflammatory fibrotic ...
N. Maugeri   +12 more
semanticscholar   +1 more source

Platelets in Viral Infections – Brave Soldiers or Trojan Horses

open access: yesFrontiers in Immunology, 2022
Viral infections are often associated with platelet activation and haemostatic complications. In line, low platelet counts represent a hallmark for poor prognosis in many infectious diseases.
Waltraud C. Schrottmaier   +3 more
doaj   +1 more source

Nucleosomes and neutrophil extracellular traps in septic and burn patients [PDF]

open access: yes, 2017
NETosis is a host defense mechanism associated with inflammation and tissue damage. Experimental models show that platelets and von Willebrand factor (VWF) are key elements for intravascular NETosis. We determined NETosis in septic and burn patients at 1
Carestia, Agostina   +8 more
core   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

open access: yesMolecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker   +14 more
wiley   +1 more source

Impacts of Cancer on Platelet Production, Activation and Education and Mechanisms of Cancer-Associated Thrombosis

open access: yesCancers, 2018
Platelets are small anucleate cells that are traditionally described as the major effectors of hemostasis and thrombosis. However, increasing evidence indicates that platelets play several roles in the progression of malignancies and in cancer-associated
L. Plantureux   +5 more
semanticscholar   +1 more source

Platelet Isolation and Activation Assays [PDF]

open access: yesBIO-PROTOCOL, 2019
Platelets regulate hemostasis and are the key determinants of pathogenic thrombosis following atherosclerotic plaque rupture. Platelets circulate in an inactive state, but become activated in response to damage to the endothelium, which exposes thrombogenic material such as collagen to the blood flow.
Burzynski, Laura C   +2 more
openaire   +6 more sources

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha   +6 more
wiley   +1 more source

Integrating platelet and coagulation activation in fibrin clot formation

open access: yesResearch and Practice in Thrombosis and Haemostasis, 2018
Platelets interact with the coagulation system in a multitude of ways, not only during the phases of thrombus formation, but also in specific areas within a formed thrombus.
F. Swieringa   +3 more
semanticscholar   +1 more source

Home - About - Disclaimer - Privacy