Results 161 to 170 of about 12,292 (326)

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

open access: yesAdvanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma   +15 more
wiley   +1 more source

Inhibitory Effect of Gliclazide on Platelet Adhesiveness and Aggregation in Alloxan Diabetic Rabbits

open access: bronze, 1979
Junji Kuwashima   +8 more
openalex   +2 more sources

Precision‐Engineered Silver Single‐Atom Carbon Dot Nanozymes for Theranostic Management of Acute Kidney Injury

open access: yesAdvanced Science, EarlyView.
Mitochondria‐targeted silver single‐atom carbon dot (T‐AgSA‐CDs) nanozymes enable dual SOD/GPx‐like ROS scavenging, real‐time imaging, and therapeutic effects for acute kidney injury (AKI). Atomically dispersed Ag sites synergize with carbon dots to restore renal redox hemostasis, protect mitochondrial function, mitigate inflammation, facilitate post ...
Tianle Tang   +10 more
wiley   +1 more source

Ambient Stable Triboelectric Nanogenerator Based on Conductive Filler Modified Silicone Rubber with Gas Barrier Encapsulation for Footstep Energy Conversion

open access: yesAdvanced Science, EarlyView.
A humidity‐tolerant triboelectric nanogenerator is developed using conductive carbon black‐modified silicone rubber and a flame‐retardant gas barrier layer. The device efficiently harvests footstep energy while maintaining stable output under 30–90% RH and over 1 million cycles.
Yi Wei   +7 more
wiley   +1 more source

All Nanozyme‐Based Cascade Reactions for Biomedical Applications: from Self‐Cascading Nanozyme to Immobilized Cascade Nanozyme

open access: yesAdvanced Science, EarlyView.
This review introduces the development and classification of all‐nanozyme cascade reaction systems, highlighting mechanistic insights and research methods for understanding catalytic features and design principles. It provides detailed classifications, surveys recent applications in biosensing and therapy, and discusses the challenges that all‐nanozyme
Caixia Zhu   +4 more
wiley   +1 more source

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