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Primary Platelet Adhesion Receptors

IUBMB Life, 2005
AbstractThrombotic diseases such as heart attack and stroke remain a major health concern in the Western world despite existing anti‐thrombotic drugs. Current studies are revealing structure‐function relationships of primary platelet adhesion receptors mediating adhesion, activation and aggregation, and the molecular mechanisms underlying platelet ...
Jana, Yip   +3 more
openaire   +2 more sources

Integrin-mediated platelet adhesion

Frontiers in Bioscience, 1998
Adhesion of platelets to the damaged subendothelium is a prerequisite reaction for the initiation of hemostasis in vivo. Platelet membranes contain high concentrations of integrins and other glycoproteins (GPs) that are involved in the platelet adhesion to the extracellular matrix.
M, Moroi, S M, Jung
openaire   +2 more sources

[Platelet adhesion and adhesive proteins--how to measure the platelet adhesiveness].

Rinsho byori. The Japanese journal of clinical pathology, 1992
We examined, platelet adhesive function in vivo by comparing the platelet retention rate (PRR) with other laboratory tests. In 71 patients, PRR did not correlate with bleeding time (BT), ristocetin-induced platelet agglutination (RIPA), vWF:AG, vWF:RCo, FVIII:C, fibrinogen, platelets counts or platelet aggregation tests.
Y, Kawai   +3 more
openaire   +1 more source

Studies on Aggregation and Adhesion of Platelets

Thrombosis and Haemostasis, 1967
SummaryA modification of the Wright method for the evaluation of the aggregation and adhesive properties of platelets is described; the test is relatively simple and can be performed in a clinical laboratory.Using this procedure, the characteristics of platelets acidified to a pH of 6.5 from their normal pH by addition of small amounts of acid citrate ...
J A, Shively, C L, Gott
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Platelet adhesion in atrial fibrillation

Thrombosis Research, 2007
Increased platelet activation has been reported in nonvalvular atrial fibrillation (AF) but it remains unclear whether or not this is due to the underlying cardiovascular diseases, clinical subtype of AF and the influence of anti-thrombotic therapy.Platelet adhesion in AF patients was assessed using a 'platelet adhesion assay', and compared to both ...
Anirban, Choudhury   +3 more
openaire   +2 more sources

Platelet adhesion to fibrin(ogen)

Blood Coagulation & Fibrinolysis, 1993
We have found that glycoprotein IIb:IIIa (GPIIb:IIIa) expressed on nonstimulated platelets is the primary receptor for platelet adhesion to immobilized fibrinogen or fibrin. At low shear rates of the blood the interaction between GPIIb:IIIa and fibrin(ogen) is strong enough to resist the shear forces exerted on the platelet as was shown with ...
S C, Endenburg   +4 more
openaire   +2 more sources

Platelet adhesion.

Progress in hemostasis and thrombosis, 1985
Platelets do not adhere to surfaces to which flowing blood is normally exposed in vivo. When the lining of a blood vessel is altered or damaged, however, platelets do adhere to the injured site. Platelet adhesion is one of the first events in the formation of hemostatic plugs and thrombi, and plays a part in the development of atherosclerotic lesions ...
M A, Packham, J F, Mustard
openaire   +1 more source

Aggregation and Adhesion of Rat Platelets

Nature, 1967
Aggregation of rat platelets caused by ADP is inhibited by adenosine in citrated but not in heparinized plasma. Rat platelets are less sensitive to aggregation by collagen than are human and rabbit platelets, which may be related to the in vivo formation and inhibition of platelet thrombi in rat vessels.
openaire   +2 more sources

Platelet adhesion

British Journal of Haematology, 1990
P G, de Groot, J J, Sixma
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PLATELET ADHESION*

Annals of the New York Academy of Sciences, 1972
T H, Spaet, M B, Stemerman
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