Results 31 to 40 of about 12,320 (324)

Clinical expression of plakophilin-2 mutations in familial arrhythmogenic right ventricular cardiomyopathy [PDF]

, 2006
Background - Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiac disorder characterized by loss of cardiomyocytes and their replacement by adipose and fibrous tissue.
Asimaki, A, Ebrahim, HY, Elliott, PM, Evans, A, Hitomi, N, McKenna, WJ, Norman, M, Pantazis, A, Sen-Chowdhry, S, Shaw, AL, Syrris, P, Ward, D   +11 more
core   +1 more source

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo [PDF]

, 2013
Neutrophil recruitment from blood to extravascular sites of sterile or infectious tissue damage is a hallmark of early innate immune responses, and the molecular events leading to cell exit from the bloodstream have been well defined1,2. Once outside the
Afonso, P., Angermann, B., Germain, R., Kastenmüller, W., Lämmermann, T., Parent, C., Wang, J.   +6 more
core   +2 more sources

Flaxseed Prevents Leukocyte and Platelet Adhesion to Endothelial Cells in Experimental Atherosclerosis by Reducing sVCAM-1 and vWF

The Scientific World Journal, 2013
We studied the possible effect of flaxseed to prevent leukocytes and platelets adhesion to endothelial cells and to reduce soluble adhesion molecules (sVCAM-1) and endothelial integrity markers (vWF) in ovariectomized rats fed a high-fat diet.
Raluca Ecaterina Haliga, Roxana Irina Iancu, Doina Butcovan, Veronica Mocanu   +3 more
doaj   +1 more source

Phase 1 Study of the E-Selectin Inhibitor GMI 1070 in Patients with Sickle Cell Anemia [PDF]

, 2014
Background\ud \ud Sickle cell anemia is an inherited disorder of hemoglobin that leads to a variety of acute and chronic complications. Abnormal cellular adhesion, mediated in part by selectins, has been implicated in the pathophysiology of the vaso ...
Cheung, Anthony, DeCastro, Laura, Flanner, Henry, Kramer, William, Kuypers, Frans, Magnani, John L, Rhee, Seungshin, Styles, Lori, Telen, Marilyn J, Thackray, Helen, Wun, Ted   +10 more
core   +8 more sources

The influence of protein adsorption on interactions of cultured human endothelial cells with polymers [PDF]

, 1987
A systematic study of the effects of polymer surface properties on the interaction with human endothelial cells (HEC) may lead to the development of small-diameter vascular grafts.
Aken, W.G. van, Bantjes, A., Beugeling, T., Detmers, J.P., Feijen, J., Vreriks, C.M., Wachem, P.B. van   +6 more
core   +4 more sources

A doença de Chagas como um modelo mecanicista para testar uma nova hipótese [PDF]

, 2008
The association between depression and cardiovascular disease is well documented. Nevertheless, the process through which they are linked remains unknown, as does the direction of this relationship.
CORREIA, Dalmo, DIAS, João Carlos Pinto, FARKOUH, Michael E., IANNI, Barbara, LOPES, Neuza, MADY, Charles, MOSOVICH, Serge A.   +6 more
core   +2 more sources

Translating proof-of-concept for platelet slip into improved antithrombotic therapeutic regimens

Platelets
Platelets are central to thrombosis. Research at the intersection of biological and physical sciences provides proof-of-concept for shear rate-dependent platelet slip at vascular stenosis and near device surfaces.
Scott J. Denardo, Pavlos P. Vlachos, Brett A. Meyers, Reza Babakhani-Galangashi, Lin Wang, Zejin Gao, James E. Tcheng   +6 more
doaj   +1 more source

Thrombospondin-1-Derived Peptide RFYVVMWK Improves the Adhesive Phenotype of CD34 Cells from Atherosclerotic Patients with Type 2 Diabetes

Cell Transplantation, 2017
CD34 + progenitor cells are growing in use for vascular repair. However, in diabetic individuals with cardiovascular diseases, these cells have dysfunctional engraftment capabilities, which compromise their use for autologous cell therapy.
Sylvie Cointe, Éric Rhéaume, Catherine Martel, Olivier Blanc-Brude, Evemie Dubé, Florence Sabatier, Françoise Dignat-George, Jean-Claude Tardif, Arnaud Bonnefoy   +8 more
doaj   +1 more source

Cell Adhesion Mechanisms in Platelets [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2008
At sites of vascular injury, platelets come into contact with the subendothelial extracellular matrix which triggers their activation and the formation of a hemostatic plug. This process is crucial for normal hemostasis, but may also lead to pathological thrombus formation causing diseases such as myocardial infarction or stroke. The initial capture of
David, Varga-Szabo, Irina, Pleines, Bernhard, Nieswandt   +2 more
openaire   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source