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Platelet Glycoproteins in Platelet Aggregation
Thrombosis and Haemostasis, 1979Thrombin stimulation alters the membrane surface of platelets so that specific components on the membrane surface interact. To identify such “aggregation factors”, tne exposed membrane proteins of washed platelets were labeled by lactoperoxidase-catalyzed iodination and tested for their association with cytoskeletal structures.
David R. Phillips +2 more
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Shear-induced platelet aggregation
The Lancet, 1990Two platelet mechanisms contribute to haemostasis and thrombosis. (1) Compounds such as thrombin activate glycoprotein IIb/IIIa; fibrinogen is the ligand. The cyclooxygenase pathway is involved and so this process is aspirin sensitive. (2) Shearing forces alone activate a different domain on glycoprotein IIb/IIIa; von Willebrand's factor is the ligand.
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RISTOCETIN AND PLATELET AGGREGATION
British Journal of Haematology, 1989M. CATTANEO, M. CHIODINI, P. MANNUCCI
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Piribedil and platelet aggregation.
Journal of medicine, 1984Piribedil at high concentrations inhibits in vitro ADP and thrombin aggregation effect on the rabbit PRP.
VAIRO G +4 more
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Biochemical and Biophysical Research Communications, 1970
Norman R. Marquis +2 more
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Norman R. Marquis +2 more
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Methods for Platelet Aggregation
1972The property of platelets to aggregate with appropriate stimuli is an essential feature of the haemostatic and thrombotic process. The study of aggregation in vitro has contributed much to our understanding of this process. The introduction of an absorptiometer (3, 20) together with continuous recording of the changes in optical density (10) have ...
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