Metabolism of 2-oxo-clopidogrel to the clopidogrel active H4 metabolite using human liver microsomes and its inhibitory effect on ADP-induced human platelet aggregation <i>ex vivo</i>: a confirmatory, placebo-controlled, parallel-group study. [PDF]
Schulz C +4 more
europepmc +1 more source
Nanoparticle‐Mediated Bubble Suppression During Droplet Solidification for Mechanical Reinforcement
Nanoparticles mediate droplet solidification by raising nucleation temperature, refining dendrites, and slowing freezing‐front advance, thereby suppressing trapped air bubbles in droplet‐based 3D printing. This strategy reduces bubble volume fraction by ∼35% and increases compressive strength by up to 39%, offering a low‐cost route to stronger printed ...
Runmiao Gao +10 more
wiley +1 more source
Divergence in postoperative platelet aggregation during antiplatelet monotherapy with aspirin in the early postoperative period following coronary artery bypass grafting: initial findings. [PDF]
Kędziora A +7 more
europepmc +1 more source
Sheet‐Size‐Dependent Mosaicity of 2D Phyllosilicate Membranes
This study explores how the size of 2D vermiculite sheets affects the structure of laminar membranes. High‐resolution x‐ray diffraction reveals how sheet size governs structural disorder and crystallinity. These changes directly impact ion permeability.
Min A Kim +6 more
wiley +1 more source
Association of Platelet Aggregation With Markers of Alzheimer Disease Pathology in Middle-Aged Participants of the Framingham Heart Study. [PDF]
Ramos-Cejudo J +18 more
europepmc +1 more source
Nanometer Layer Coating to Lactose Particles for Optimization of Dexamethasone Pulmonary Delivery
Nanometer layer coating (NLC) was investigated and its mechanism illustrated by advanced characterization techniques. The effects and application for the inhalation of dexamethasone (DEX) were demonstrated through in vitro and in vivo evaluation. This approach increased DEX bioavailability and enabled the dose to be reduced to 1/30 of the intravenous ...
Qin Nie +11 more
wiley +1 more source
Platelet aggregation and its modulation using antithrombotic agents. [PDF]
Srivastava N +5 more
europepmc +1 more source
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei +10 more
wiley +1 more source
Synergistic effects of anticoagulants and platelet aggregation inhibitors with immune checkpoint inhibitors in cancer therapy: a comprehensive review of preclinical and clinical evidence. [PDF]
Kött J +7 more
europepmc +1 more source
Sulfur‐precursor and ligand engineering regulate the nucleation, morphology, and energetic disorder of CuSbS2 nanocrystals for dopant‐free inorganic hole‐transport layers in perovskite solar cells. Thiourea‐assisted synthesis combined with optimized OAm/OAc coordination suppresses excessive anisotropic growth, enabling mixed plate‐like/quasi‐spherical ...
Ibrahimhan Dilci, Savas Sonmezoglu
wiley +1 more source

