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Platelet function tests: a comparative review [PDF]
Rita Paniccia,1,2 Raffaella Priora,1,2 Agatina Alessandrello Liotta,2 Rosanna Abbate1,2 1Department of Experimental and Clinical Medicine, Thrombosis Center, University of Florence, Florence, Italy; 2Department of Heart and Vessels, Azienda Ospedaliero ...
Paniccia R +3 more
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Platelet function in overt hypothyroidism
BACKGROUND: Hypothyroidism is associated with a shift of the hemostatic system to a hypocoagulable state and inhibited platelet function. However, previous studies did not consider the different degrees of response to thyroxine treatment and its effect ...
Abeer Khalid Al-Ghumlas +2 more
doaj +1 more source
Platelet function tests are essential to profile platelet dysfunction and dysregulation in hemostasis and thrombosis. Clinically they provide critical guidance to the patient management and therapeutic evaluation.
Yingqi Zhang +8 more
doaj +1 more source
Optimized tool for evaluation of platelet function measured by impedance aggregometry
Platelet aggregation measured by impedance aggregometry is highly dependent on platelet count. We previously developed a tool to interpret impedance aggregometry based on the strong linear correlation between platelet counts and platelet aggregation at ...
Anna Schultz-Lebahn +3 more
doaj +1 more source
Traditionally developed for diagnosis of bleeding disorders, platelet function assays have become increasingly used in basic research on platelet physiology, in phenotype-genotype associations in bleeding disorders, in drug development as surrogate endpoints of efficacy of new antiplatelet therapy, and to an extent, in the monitoring of antiplatelet ...
openaire +3 more sources
Perioperative management and monitoring of antiplatelet agents: a focused review on aspirin and P2Y inhibitors [PDF]
Platelets play pivotal roles in hemostasis as well as pathological arterial thrombosis. The combination of aspirin and a P2Y12 inhibitor has become the mainstay therapy in the ageing population with cardiovascular conditions, particularly during and ...
Michael A. Mazzeffi +3 more
doaj +1 more source
Antiplatelet therapy – platelet function test for platelet response assessment [PDF]
Dual antiplatelet therapy is the main pharmacological mechanism used to suppress platelet function in order to prevent thrombotic complications following percutaneous coronary angioplasty.
D. Dineva, Е. Doncheva, I. Paskaleva
doaj +3 more sources
Light transmission aggregometry (LTA) is the gold standard for the diagnosis of platelet function disorders (PFDs). The requirement of customized aggregometer, large blood volume, normal platelet count and processing within 4 hours of venipuncture for ...
Rutvi Gautam Dave +7 more
doaj +1 more source
Platelet Phenotyping and Function Testing in Thrombocytopenia [PDF]
Patients who suffer from inherited or acquired thrombocytopenia can be also affected by platelet function defects, which potentially increase the risk of severe and life-threatening bleeding complications. A plethora of tests and assays for platelet phenotyping and function analysis are available, which are, in part, feasible in clinical practice due ...
Kerstin Jurk, Yavar Shiravand
openaire +2 more sources
Long-term treated HIV infection is associated with platelet mitochondrial dysfunction
HIV infection and antiretroviral therapy have been linked to mitochondrial dysfunction. The role of platelet mitochondrial dysfunction in thrombosis, immunoregulation and age-related diseases is increasingly appreciated.
Wouter A. van der Heijden +12 more
doaj +1 more source

