Results 31 to 40 of about 170,471 (154)

Functional characterization of a nanobody-based glycoprotein VI-specific platelet agonist

Research and Practice in Thrombosis and Haemostasis
Background: Glycoprotein (GP)VI is a platelet-specific collagen receptor required for platelet activation during hemostasis. Platelet reactivity toward collagen is routinely assessed during diagnostic workup of platelet disorders.
Minka Zivkovic, Elisabeth Pols - van Veen, Vossa van der Vegte, Silvie A.E. Sebastian, Annick S. de Moor, Suzanne J.A. Korporaal, Roger E.G. Schutgens, Rolf T. Urbanus, Erik Beckers, Michiel Coppens, Jeroen Eikenboom, Louise Hooimeijer, Gerard Jansen, Roger Schutgens, Rolf Urbanus, Minka Zivkovic, Emile van den Akker, Wala Al Arashi, Ryanne Arisz, Lieke Baas, Ruben Bierings, Maartje van den Biggelaar, Johan Boender, Anske van der Bom, Mettine Bos, Martijn Brands, Annelien Bredenoord, Laura Bukkems, Lex Burdorf, Jessica Del Castillo Alferez, Michael Cloesmeijer, Marjon Cnossen, Mariëtte Driessens, Jeroen Eikenboom, Karin Fijnvandraat, Kathelijn Fischer, Geertje Goedhart, Tine Goedhart, Samantha Gouw, Rieke van der Graaf, Masja de Haas, Lotte Haverman, Jan Hazelzet, Shannon van Hoorn, Elise Huisman, Nathalie Jansen, Alexander Janssen, Sean de Jong, Sjoerd Koopman, Marieke Kruip, Sebastiaan Laan, Frank Leebeek, Nikki van Leeuwen, Hester Lingsma, Moniek de Maat, Ron Mathôt, Felix van der Meer, Karina Meijer, Sander Meijer, Stephan Meijer, Iris van Moort, Caroline Mussert, Hans Kristian Ploos van Amstel, Suzanne Polinder, Diaz Prameyllawati, Simone Reitsma, Eliza Roest, Lorenzo Romano, Saskia Schols, Roger Schutgens, Rolf Urbanus, Carin Uyl, Jan Voorberg, Huan Zhang, Minka Zivkovic   +74 more
doaj   +1 more source

Novel SLFN14 mutation associated with macrothrombocytopenia in a patient with severe haemorrhagic syndrome

Orphanet Journal of Rare Diseases, 2023
Background Platelet-type bleeding disorder 20 (BDPLT20), as known as SLFN14-related thrombocytopenia, is a rare inherited thrombocytopenia (IT). Previously, only 5 heterozygous missense mutations in the SLFN14 gene have been reported.
Dmitrii Polokhov, Daria Fedorova, Anastasiya Ignatova, Evgeniya Ponomarenko, Elena Rashevskaya, Alexey Martyanov, Nadezhda Podoplelova, Maxim Aleksenko, Irina Mersiyanova, Elena Seregina, Aleksandr Poletaev, Ekaterina Truchina, Elena Raykina, Svetlana Plyasunova, Galina Novichkova, Pavel Zharkov, Mikhail Panteleev   +16 more
doaj   +1 more source

Aggregometry in the settings of thrombocytopenia, thrombocytosis and antiplatelet therapy

Platelets, 2018
A variety of laboratory tests have been developed, which can diagnose a number of both congenital and acquired disorders of platelet function. Many tests of platelet function measure the ability of platelets to adhere to each other, forming platelet ...
GianMarco Podda, Mariangela Scavone, Eti Alessandra Femia, Marco Cattaneo   +3 more
doaj   +1 more source

Antiplatelet Therapy and Platelet Function Testing [PDF]

Clinical Cardiology, 2008
Eugene Braunwald,∗ Dominick Angiolillo,† Eric Bates,‡ Peter B. Berger,§ Deepak Bhatt,|| Christopher P. Cannon,∗ Mark I. Furman,¶ Paul Gurbel,∗∗ Alan D. Michelson,†† Eric Peterson,‡‡ Stephen Wiviott∗ ∗TIMI Study Group, Cardiovascular Division, Brigham and Women’s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts ...
Braunwald, Eugene, Angiolillo, Dominick, Bates, Eric R., Berger, Peter B., Bhatt, Deepak, Cannon, Christopher P., Furman, Mark I., Gurba, Paul E., Michelson, Alan D., Peterson, Eric, Wiviott, Stephen   +10 more
openaire   +5 more sources

Platelet function in the postprandial period

Thrombosis Journal, 2012
Background Postprandial hyperlipidemia and hyperglycemia have been related to cardiovascular events. Among different underlying mechanisms platelet activation seems to be responsible too.
Sinzinger Helmut, Berent Robert
doaj   +1 more source

Platelet phenotypes and practical aspects of platelet function testing in cardiology

Рациональная фармакотерапия в кардиологии, 2023
The assessment of platelet dysfunction is usually used by hematologists to diagnose inherited (such as Bernard-Soulier syndrome, platelet-type-von Willebrand disease, Glanzmann thrombasthenia, etc.), and acquired (symptomatic) platelet disorders (in ...
Zh. D. Kobalava, A. S. Pisaryuk, A. A. Filkova, E. S. Tukhsanboev, A. A. Boldyreva, D. P. Lazutova, I. A. Meray, M. A. Panteleev   +7 more
doaj   +1 more source

Platelet function after cardiac surgery and its association with severe postoperative bleeding: the PLATFORM study

Platelets, 2019
Platelet dysfunction after cardiac surgery is a determinant of postoperative bleeding. The existing guidelines suggest the use of desmopressin and/or platelet concentrate transfusions in case of platelet dysfunction in bleeding patients, but no cut-off ...
Marco Ranucci, Valeria Pistuddi, Umberto Di Dedda, Lorenzo Menicanti, Carlo De Vincentiis, Ekaterina Baryshnikova   +5 more
doaj   +1 more source

Platelet function testing: dead or alive [PDF]

Journal of Thrombosis and Haemostasis, 2018
Essentials Pharmacodynamic response to antiplatelet medication is heterogeneous. Platelet reactivity to dual antiplatelet therapy was analyzed by three platelet function assays. The prevalence of high and low platelet reactivity differed significantly between assays.
Helten, C., Naguib, D., Dannenberg, L., Pöhl, M., Ayhan, A., Hohlfeld, T., Levkau, Bodo, Kelm, M., Zeus, T., Polzin, A.   +9 more
openaire   +3 more sources

The Laboratory Tests for Platelet Function

Eurasian Journal of Medicine, 2019
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Aves Editorial Aves Editorial
doaj  

Platelet dysfunction and inhibition of multiple electrode platelet aggregometry caused by penicillin

Thrombosis Journal, 2010
Beta-lactam antibiotics, e.g. penicillin, may inhibit platelet function and lead to reduced response in light transmission aggregometry and adhesion. However, influence on platelet function tests more commonly used in clinical practice, such as multiple ...
von Beckerath Nicolas, Okrojek Rainer, von Beckerath Olga, Schulz Christian, Massberg Steffen   +4 more
doaj   +1 more source