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Platelet Function in Aging [PDF]
Frontiers in Cardiovascular Medicine, 2019 Aging is associated with an increased incidence of cardiovascular disease and thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus formation, making them a key player in thrombotic disorders.
Jessica Le Blanc +3 more
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Aquaporins in platelet function [PDF]
Platelets, 2021 Structurally, aquaporins (AQPs) are small channel proteins with monomers of ~ 30 kDa that are assembled as tetramers to form pores on cell membranes. Aquaporins mediate the conduction of water but at times also small solutes including glycerol across ...
Ejaife O. Agbani, Alastair W. Poole
doaj +3 more sources
Seminars in Thrombosis and Hemostasis, 2016 Traditionally developed for diagnosis of bleeding disorders, platelet function assays have become increasingly used in basic research on platelet physiology, in phenotype-genotype associations in bleeding disorders, in drug development as surrogate endpoints of efficacy of new antiplatelet therapy, and to an extent, in the monitoring of antiplatelet ...
Marie Lordkipanidze
exaly +4 more sources
The Plasma Glycoprotein Milieu in the Hemato-Oncological Patient Inhibits Platelet Function [PDF]
BiomoleculesHemato-oncological patients with chemotherapy-induced thrombocytopenia are a major recipient group of frequent platelet (PLT) transfusion. Prophylactic platelet transfusions are administered when platelet counts fall below 10 × 109 PLT/L, to prevent ...
Iris M. De Cuyper +10 more
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Pediatrics and Neonatology, 2018 Background: This study aims at evaluating the influence of platelet count, platelet mass index, and platelet function on the spontaneous closure of ductus arteriosus in prematurity.
Dilek Kahvecioglu +9 more
doaj +3 more sources
Platelet Membrane Receptor Proteolysis: Implications for Platelet Function
Frontiers in Cardiovascular Medicine, 2021 The activities of adhesion and signaling receptors in platelets are controlled by several mechanisms. An important way of regulation is provided by proteolytic cleavage of several of these receptors, leading to either a gain or a loss of platelet ...
Jiayu Wu +3 more
doaj +1 more source
JACC: Basic to Translational Science, 2022 Summary: Hypofibrinolysis is a recently-recognized risk factor for recurrent cardiovascular events in patients with ST-segment elevation myocardial infarction (STEMI), but the mechanistic determinants of this are not well understood.
Rahim Kanji, MB, BS +5 more
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Ontogeny of platelet function [PDF]
Blood Advances, 2019 AbstractAlthough the hemostatic potential of adult platelets has been investigated extensively, regulation of platelet function during fetal life is less clear. Recent studies have provided increasing evidence for a developmental control of platelet function during fetal ontogeny.
Andreas Margraf +2 more
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Epidural hematoma after thoracic epidural analgesia in a patient treated with ketorolac, mefenamic acid, and naftazone: a case report [PDF]
Korean Journal of Anesthesiology, 2014 A 26-year-old male undergoing thoracotomy and bleeding control received a preoperative thoracic epidural for postoperative analgesia. On the fifth postoperative day, paralysis of both lower limbs occurred and urgent magnetic resonance imaging showed ...
Dae Geun Jeon +3 more
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Platelet function defects [PDF]
Haemophilia, 2008 Summary. Inherited defects of platelet function are a heterogeneous group of disorders that can result in bleeding symptoms ranging from mild bruising to severe mucocutaneous haemorrhage. These defects may be classified according to their effect on the various steps of platelet microthrombi formation including initiation, extension and cohesion, or ...
D, Simon, T, Kunicki, D, Nugent
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